Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3287-3292

  Russo, Lilian C ^a   Castro, Leandro M ^a   Gozzo, Fabio C ^b   Ferro, Emer S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

G protein coupled receptor; Intracellular peptide; Oligopeptidase; siRNA; Ubiquitinproteasome system

Indexed keywords

INTRACELLULAR PEPTIDE; ISOPRENALINE; KT 5720; PEPTIDE; SMALL INTERFERING RNA; THIMET OLIGOPEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CARBAZOLES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENES, REPORTER; HEK293 CELLS; HUMANS; ISOPROTERENOL; LUCIFERASES; METALLOENDOPEPTIDASES; PEPTIDES; PROTEIN KINASE INHIBITORS; PYRROLES; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

MAMMALIA;

EID: 84866602436     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.07.002     Document Type: Article

References (35)

1. V. Oliveira, M. Campos, J.P. Hemerly, E.S. Ferro, A.C.M. Camargo, and M.A. Juliano Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (EC 3.4.24.16): Comparison with thimet oligopeptidase (EC 3.4.24.15) and neprilysin (EC 3.4.24.11) Anal. Biochem. 292 2001 257 265
2. N.D. Rawlings, and A.J. Barrett Evolutionary families of metallopeptidases Methods Enzymol. 248 1995 183 228
3. M. Demasi, G.M. Piassa Filho, L.M. Castro, J.C. Ferreira, V. Rioli, and E.S. Ferro Oligomerization of the cysteinyl-rich oligopeptidase EP24.15 is triggered by S-glutathionylation Free Radic. Biol. Med. 44 2008 1180 1190
4. E.S. Ferro, J.W. Tullai, M.J. Glucksman, and J.L. Roberts Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15) DNA Cell Biol. 18 1999 781 789
5. J.D. Fontenele-Neto, E.E. Massarelli, P.A. Gurgel Garrido, A. Beaudet, and E.S. Ferro Comparative fine structural distribution of endopeptidase 24.15 (EC3.4.24.15) and 24.16 (EC3.4.24.16) in rat brain J. Comp. Neurol. 438 2001 399 410
6. J.H. Kessler, S. Khan, U. Seifert, S. Le Gall, K.M. Chow, and A. Paschen Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes Nat. Immunol. 12 2011 45 53
7. S.I. Kim, A. Pabon, T.A. Swanson, and M.J. Glucksman Regulation of cell-surface major histocompatibility complex class I expression by the endopeptidase EC3.4.24.15 (thimet oligopeptidase) Biochem. J. 375 2003 111 120
8. F.C. Portaro, M.D. Gomes, A. Cabrera, B.L. Fernandes, C.L. Silva, and E.S. Ferro Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol Biochem. Biophys. Res. Commun. 255 1999 596 601
9. C.L. Silva, F.C. Portaro, V.L. Bonato, A.C. de Camargo, and E.S. Ferro Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation Biochem. Biophys. Res. Commun. 255 1999 591 595
10. V. Rioli, F.C. Gozzo, A.S. Heimann, A. Linardi, J.E. Krieger, and C.S. Shida Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme J. Biol. Chem. 278 2003 8547 8555
11. F.M. Cunha, D.A. Berti, Z.S. Ferreira, C.F. Klitzke, R.P. Markus, and E.S. Ferro Intracellular peptides as natural regulators of cell signaling J. Biol. Chem. 283 2008 24448 24459
12. D.A. Berti, C. Morano, L.C. Russo, L.M. Castro, F.M. Cunha, and X. Zhang Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells J. Biol. Chem. 284 2009 14105 14116
13. Russo, L.C.; Asega, A.F.; Castro, L.M.; Negraes, P.D.; Cruz, L.; Gozzo, F.C.; et al. (2012) Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3 and calmodulin. Proteomics, 12, http://dx.doi.org/10.1002/pmic.201200032.
14. C. Sanden, J. Enquist, S.H. Bengtson, H. Herwald, and L.M. Leeb-Lundberg Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation J. Pharmacol. Exp. Ther. 326 2008 24 32
15. F.R. Carreno, C.N. Goni, L.M. Castro, and E.S. Ferro 14-3-3 epsilon modulates the stimulated secretion of endopeptidase 24.15 J. Neurochem. 93 2005 10 25
16. L.C. Russo, C.N. Goni, L.M. Castro, A.F. Asega, A.C. Camargo, and C.A. Trujillo Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation FEBS J. 276 2009 4358 4371
17. V. Rioli, A. Kato, F.C. Portaro, G.K. Cury, K. te Kaat, and B. Vincent Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15 Biochem. Biophys. Res. Commun. 250 1998 5 11
18. D. Steer, R. Lew, P. Perlmutter, A.I. Smith, and M.I. Aguilar Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of beta-amino acids Biochemistry 41 2002 10819 10826
19. T. Saric, C.I. Graef, and A.L. Goldberg Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases J. Biol. Chem. 279 2004 46723 46732
20. S. Udenfriend, S. Stein, P. Bohlen, W. Dairman, W. Leimgruber, and M. Weigele Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range Science 178 1972 871 872
21. F.Y. Che, R. Biswas, and L.D. Fricker Relative quantitation of peptides in wild-type and Cpe(fat/fat) mouse pituitary using stable isotopic tags and mass spectrometry J. Mass Spectrom. 40 2005 227 237
22. F.Y. Che, J. Lim, H. Pan, R. Biswas, and L.D. Fricker Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary Mol. Cell. Proteomics 4 2005 1391 1405
23. C. Morano, X. Zhang, and L.D. Fricker Multiple isotopic labels for quantitative mass spectrometry Anal. Chem. 80 2008 9298 9309
24. X. Zhang, F.Y. Che, I. Berezniuk, K. Sonmez, L. Toll, and L.D. Fricker Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing J. Neurochem. 107 2008 1596 1613
25. L.D. Fricker, J.S. Gelman, L.M. Castro, F.C. Gozzo, and E.S. Ferro Peptidomic analysis of HEK293T cells: Effect of the proteasome inhibitor epoxomicin on intracellular peptides J. Proteome Res. 11 2012 1981 1990
26. J.S. Gelman, J. Sironi, L.M. Castro, E.S. Ferro, and L.D. Fricker Peptidomic Analysis of Human Cell Lines J. Proteome Res. 10 2011 1583 1592
27. G.P. Anderson Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms Clin. Rev. Allergy Immunol. 31 2006 119 130
28. J.M. Schmitt, and P.J. Stork Beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf J. Biol. Chem. 275 2000 25342 25350
29. Berti, D.A.; Russo, L.C.; Castro, L.M.; Cruz, L.; Gozzo, F.C.; Heimann, J.C.; et al. (2012) Identification of intracellular peptides in rat adipose tissue: insights into insulin resistance. Proteomics, 12, http://dx.doi.org/10. 1002/pmic.201200051.
30. A.S. Heimann, M.H. Favarato, F.C. Gozzo, V. Rioli, F.R. Carreno, and M.N. Eberlin ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight Physiol. Genomics 20 2005 173 182
31. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811
32. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498
33. E. Song, S.K. Lee, J. Wang, N. Ince, N. Ouyang, and J. Min RNA interference targeting Fas protects mice from fulminant hepatitis Nat. Med. 9 2003 347 351
34. A. de Fougerolles, H.P. Vornlocher, J. Maraganore, and J. Lieberman Interfering with disease: a progress report on siRNA-based therapeutics Nat. Rev. Drug Discov. 6 2007 443 453
35. Y. Higuchi, S. Kawakami, and M. Hashida Strategies for in vivo delivery of siRNAs: recent progress BioDrugs 24 2010 195 205