The TGF-β1/Smad/CTGF pathway and corpus cavernosum fibrous-muscular alterations in rats with streptozotocin-induced diabetes

Journal of Andrology

Volumn 33, Issue 4, 2012, Pages 651-659

  Zhou, Feng ^a   Li, Guang Yong ^a   Gao, Zhe Zhu ^a   Liu, Jing ^a   Liu, Tao ^a   Li, Wei Ren ^a   Cui, Wan Shou ^a   Bai, Guang Yi ^a   Xin, Zhong Cheng ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Collagen fibers; Connective tissue growth factor; Elastic fibers; Erectile dysfunction; Smad; Transforming growth factor

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; CONNECTIVE TISSUE GROWTH FACTOR; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; FIBROBLAST; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; DIABETES MELLITUS, EXPERIMENTAL; ERECTILE DYSFUNCTION; FIBROSIS; MALE; MUSCLES; PENILE ERECTION; PENIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84866558706     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.111.014456     Document Type: Article

References (26)

1. Adeniyi AF, Adeleye JO, Adeniyi CY. Diabetes, sexual dysfunction and therapeutic exercise: a 20 year review. Curr Diabetes Rev. 2010;6:201-206.
2. Ahn GJ, Sohn YS, Kang KK, Ahn BO, Kwon JW, Kang SK, Lee BC, Hwang WS. The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats. Int J Impot Res. 2005; 17:134-141.
3. Akkus E, Carrier S, Baba K, Hsu GL, Padmanathan H, Nunes L, Lue TF. Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence. Br J Urol. 1997;79:47-53.
4. Castanares C, Redondo-Horcajo M, Magan-Marchal N, ten Dijke P, Lamas S, Rodriguez-Pascual F. Signaling by ALK5 mediates TGFb-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci. 2007;120:1256-1266.
5. El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res. 1999;11:123- 132.
6. Fedele D. Therapy insight: sexual and bladder dysfunction associated with diabetes mellitus. Nat Clin Pract Urol. 2005;2:282-290.
7. Gonzalez-Cadavid NF. Mechanisms of penile fibrosis. J Sex Med. 2009;6:353-362.
8. Gray MA, Wang CC, Sacks MS, Yoshimura N, Chancellor MB, Nagatomi J. Time-dependent alterations of select genes in streptozotocin-induced diabetic rat bladder. Urology. 2008;71: 1214-1219.
9. Hsu GL, Brock G, Vonheyden B, Nunes L, Lue TF, Tanagho EA. The distribution of elastic fibrous elements within the human penis. Br J Urol. 1994;73:566-571.
10. Iacono F, Giannella R, Somma P, Manno G, Fusco F, Mirone V. Histological alterations in cavernous tissue after radical prostatectomy. J Urol. 2005;173:1673-1676.
11. Liu B, Zhang H, Xu C, Yang G, Tao J, Huang J, Wu J, Duan X, Cao Y, Dong J. Neuroprotective effects of icariin on corticosteroneinduced apoptosis in primary cultured rat hippocampal neurons. Brain Res. 2011;1375:59-67.
12. Luangkhot R, Rutchik S, Agarwal V, Puglia K, Bhargava G, Melman A. Collagen alterations in the corpus cavernosum of men with sexual dysfunction. J Urol. 1992;148:467-471.
13. Massague J, Chen YG. Controlling TGF-b signaling. Genes Dev. 2000;14:627-644.
14. Moreland RB. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res. 1998;10:113-120.
15. Moreland RB, Traish A, McMillin MA, Smith B, Goldstein I, Saenz de Tejada I. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol. 1995;153:826-834.
16. Navarrete RV, Munspoz JG, Martín LL, Cardoso JV, Enguita CG. Metabolic syndrome and erectile dysfunction [in Spanish]. Arch Esp Urol. 2010;63:673-678
17. Rodriguez-Vita J, Sanchez-Galan E, Santamaria B, Sanchez-Lopez E, Rodrigues-Diez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M. Essential role of TGF-b/Smad pathway on statin dependent vascular smooth muscle cell regulation. Plos One. 2008;3:e3959.
18. Sattar AA, Wespes E, Schulman CC. Computerized measurement of penile elastic fibres in potent and impotent men. Eur Urol. 1994; 25:142-144.
19. Shabsigh R, Klein LT, Seidman S, Kaplan SA, Lehrhoff BJ, Ritter JS. Increased incidence of depressive symptoms in men with erectile dysfunction. Urology. 1998;52:848-852.
20. Twigg SM, Cooper ME, Cooper ME. The time has come to target connective tissue growth factor in diabetic complications. Diabetologia. 2004;47:965-968.
21. Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-b/ Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem. 2001; 276:17058-17062.
22. Verrecchia F, Mauviel A. Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep. 2002;4:143-149.
23. Wang SN, DeNichilo M, Brubaker C, Hirschberg R. Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int. 2001;60:96-105.
24. Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa S, Miyazono K. TGF-b receptor kinase inhibitor enhances growth and integrity of embryonic stem cellderived endothelial cells. J Cell Biol. 2003;163:1303-1311.
25. Yamagishi S, Inagaki Y, Okamoto T, Amano S, Koga K, Takeuchi M. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells. Kidney Int. 2003;63:464-473.
26. Zhang LW, Piao S, Choi MJ, Shin HY, Jin HR, Kim WJ, Song SU, Han JY, Park SH, Mamura M, Kim SJ, Ryu JK, Suh JK. Role of increased penile expression of transforming growth factor-b1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J Sex Med. 2008;5:2318- 2329.