Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: Confirmatory and novel results in early and late sepsis

BMC Genomics

Volumn 13, Issue 1, 2012, Pages

  Bhatty, Minny ^a   Fan, Ruping ^b   Muir, William M ^c   Pruett, Stephen B ^a,b   Nanduri, Bindu ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Intra abdominal sepsis; Microarray; Peritoneal leukocytes

Indexed keywords

EARLY B CELL FACTOR 1; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 10; PROTEIN PLAGL2; REGULATOR PROTEIN; STRAWBERRY NOTCH HOMOLOG 2; TRANSCRIPTION FACTOR 7; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; CELL COUNT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEAL CAVITY; PERITONEAL FLUID; PERITONEUM CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEPSIS; SPECIES DIFFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE TRANSCRIPTION FACTORS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKERS; INTRAABDOMINAL INFECTIONS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PERITONEUM; REPRESSOR PROTEINS; RNA-BINDING PROTEINS; SEPSIS; T CELL TRANSCRIPTION FACTOR 1; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

ESCHERICHIA COLI; MUS;

EID: 84866557005     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-13-509     Document Type: Article

References (56)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29(7):1303-1310. 10.1097/00003246-200107000-00002, 11445675.
2. Chung TP, Laramie JM, Meyer DJ, Downey T, Tam LH, Ding H, Buchman TG, Karl I, Stormo GD, Hotchkiss RS, et al. Molecular diagnostics in sepsis: from bedside to bench. J Am Coll Surg 2006, 203(5):585-598. 10.1016/j.jamcollsurg.2006.06.028, 17084318.
3. Tang BM, Huang SJ, McLean AS. Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care 2010, 14(6):R237. 10.1186/cc9392, 3219990, 21190579.
4. Szatanik M, Hong E, Ruckly C, Ledroit M, Giorgini D, Jopek K, Nicola MA, Deghmane AE, Taha MK. Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin. PLoS One 2011, 6(7):e22210. 10.1371/journal.pone.0022210, 3141004, 21811575.
5. Hegde A, Tamizhselvi R, Manikandan J, Melendez AJ, Moochhala SM, Bhatia M. Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Mol Med 2010, 16(5-6):188-198. 2864813, 20454520.
6. Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir Crit Care Med 2006, 173(3):256-263. 10.1164/rccm.200510-1604OE, 16239619.
7. Pieracci FM, Barie PS. Management of severe sepsis of abdominal origin. Scand J Surg 2007, 96(3):184-196.
8. Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, Barrette TR, Shankar-Sinha S, Sarma VJ, Padgaonkar VA, Ward PA. Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation. Am J Pathol 2001, 159(4):1199-1209. 10.1016/S0002-9440(10)62505-9, 1850525, 11583946.
9. Mercer-Jones MA, Shrotri MS, Peyton JC, Remick DG, Cheadle WG. Neutrophil sequestration in liver and lung is differentially regulated by C-X-C chemokines during experimental peritonitis. Inflammation 1999, 23(4):305-319.
10. Van Otteren GM, Strieter RM, Kunkel SL, Paine R, Greenberger MJ, Danforth JM, Burdick MD, Standiford TJ. Compartmentalized expression of RANTES in a murine model of endotoxemia. J Immunol 1995, 154(4):1900-1908.
11. Cavaillon JM, Annane D. Compartmentalization of the inflammatory response in sepsis and SIRS. J Endotoxin Res 2006, 12(3):151-170. 10.1179/096805106X102246, 16719987.
12. Shenkar R, Abraham E. Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein. J Immunol 1999, 163(2):954-962.
13. Parsey MV, Tuder RM, Abraham E. Neutrophils are major contributors to intraparenchymal lung IL-1 beta expression after hemorrhage and endotoxemia. J Immunol 1998, 160(2):1007-1013.
14. Koay MA, Christman JW, Wudel LJ, Allos T, Cheng DS, Chapman WC, Blackwell TS. Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors. Am J Physiol Lung Cell Mol Physiol 2002, 283(6):L1247-L1254.
15. Mbopi Keou FX, Bloch F, Buu Hoi A, Lavril M, Belec L, Mokbat JE, Petite JP, Acar JF. Spontaneous peritonitis in cirrhotic hospital in-patients: retrospective analysis of 101 cases. Q J Med 1992, 83(301):401-407.
16. De Waele JJ, Hoste EA, Blot SI. Blood stream infections of abdominal origin in the intensive care unit: characteristics and determinants of death. Surg Infect (Larchmt) 2008, 9(2):171-177.
17. Buras JA, Holzmann B, Sitkovsky M. Animal models of sepsis: setting the stage. Nat Rev Drug Discov 2005, 4(10):854-865. 10.1038/nrd1854, 16224456.
18. Rittirsch D, Hoesel LM, Ward PA. The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol 2007, 81(1):137-143.
19. Pruett SB, Fan R, Cheng B, Glover M, Tan W, Deng X. Innate immunity and inflammation in sepsis: mechanisms of suppressed host resistance in mice treated with ethanol in a binge-drinking model. Toxicol Sci 2010, 117(2):314-324. 10.1093/toxsci/kfq215, 2948819, 20624996.
20. Bhatty M, Jan BL, Tan W, Pruett SB, Nanduri B. Role of acute ethanol exposure and TLR4 in early events of sepsis in a mouse model. Alcohol 2011, 45(8):795-803. 10.1016/j.alcohol.2011.07.003, 3293500, 21872420.
21. Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am J Pathol 2000, 157(2):473-484. 10.1016/S0002-9440(10)64559-2, 1850132, 10934151.
22. Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 1995, 154(1):97-105.
23. Stroncek DF, Skubitz KM, McCullough JJ. Biochemical characterization of the neutrophil-specific antigen NB1. Blood 1990, 75(3):744-755.
24. Marchbank KJ, Watson CC, Ritsema DF, Holers VM. Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function. J Immunol 2000, 165(5):2354-2361.
25. Gommerman JL, Oh DY, Zhou X, Tedder TF, Maurer M, Galli SJ, Carroll MC. A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. J Immunol 2000, 165(12):6915-6921.
26. Fontayne A, Dang PM, Gougerot-Pocidalo MA, El-Benna J. Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry 2002, 41(24):7743-7750. 10.1021/bi011953s, 12056906.
27. Guignant C, Voirin N, Venet F, Poitevin F, Malcus C, Bohe J, Lepape A, Monneret G. Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients. Intensive Care Med 2009, 35(11):1859-1867. 10.1007/s00134-009-1610-5, 19662382.
28. Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 1996, 81(4):1449-1453. 10.1210/jc.81.4.1449, 8636349.
29. Wang RL, Kang FX. Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin. Chin J Traumatol 2010, 13(3):152-157.
30. Ueda S, Nishio K, Minamino N, Kubo A, Akai Y, Kangawa K, Matsuo H, Fujimura Y, Yoshioka A, Masui K, et al. Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am J Respir Crit Care Med 1999, 160(1):132-136. 10.1164/ajrccm.160.1.9810006, 10390390.
31. Wu R, Higuchi S, Dong W, Ji Y, Zhou M, Marini CP, Ravikumar TS, Wang P. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Mol Med (Cambridge, Mass) 2009, 15(1-2):28-33.
32. Temmesfeld-Wollbruck B, Brell B, zu Dohna C, Dorenberg M, Hocke AC, Martens H, Klar J, Suttorp N, Hippenstiel S. Adrenomedullin reduces intestinal epithelial permeability in vivo and in vitro. Am J Physiol Gastrointest Liver Physiol 2009, 297(1):G43-G51. 10.1152/ajpgi.90532.2008, 19423749.
33. Sugimoto K, Galle C, Preiser JC, Creteur J, Vincent JL, Pradier O. Monocyte CD40 expression in severe sepsis. Shock 2003, 19(1):24-27. 10.1097/00024382-200301000-00005, 12558139.
34. Schwulst SJ, Muenzer JT, Chang KC, Brahmbhatt TS, Coopersmith CM, Hotchkiss RS. Lymphocyte phenotyping to distinguish septic from nonseptic critical illness. J Am Coll Surg 2008, 206(2):335-342. 10.1016/j.jamcollsurg.2007.07.038, 18222389.
35. Manda P, Freeman MG, Bridges SM, Jankun-Kelly TJ, Nanduri B, McCarthy FM, Burgess SC. GOModeler-a tool for hypothesis-testing of functional genomics datasets. BMC Bioinformatics 2010, 11(Suppl 6):S29. 10.1186/1471-2105-11-S6-S29, 3026376, 20946613.
36. Tang BM, McLean AS, Dawes IW, Huang SJ, Lin RC. The use of gene-expression profiling to identify candidate genes in human sepsis. Am J Respir Crit Care Med 2007, 176(7):676-684. 10.1164/rccm.200612-1819OC, 17575094.
37. Breton A, Descoteaux A. Protein kinase C-alpha participates in FcgammaR-mediated phagocytosis in macrophages. Biochem Biophys Res Commun 2000, 276(2):472-476. 10.1006/bbrc.2000.3511, 11027499.
38. Harvath L, McCall CE, Bass DA, McPhail LC. Inhibition of human neutrophil chemotaxis by the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine. J Immunol 1987, 139(9):3055-3061.
39. Mizutani A, Furukawa T, Adachi Y, Ikehara S, Taketani S. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. J Biol Chem 2002, 277(18):15851-15858. 10.1074/jbc.M111431200, 11832486.
40. O'Riordan M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 1999, 11(1):21-31. 10.1016/S1074-7613(00)80078-3, 10435576.
41. Minino AM, Arias E, Kochanek KD, Murphy SL, Smith BL. Deaths: final data for 2000. Natl Vital Stat Rep 2002, 50(15):1-119.
42. Pruett SB, Zheng Q, Fan R, Matthews K, Schwab C. Ethanol suppresses cytokine responses induced through toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking. Alcohol (Fayetteville, NY) 2004, 33(2):147-155.
43. Takano M, Nishimura H, Kimura Y, Washizu J, Mokuno Y, Nimura Y, Yoshikai Y. Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice. J Immunol 1998, 161(6):3019-3025.
44. Goronzy J, Weyand C, Quan J, Fathman CG, O'Hanley P. Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2. J Immunol 1989, 142(4):1134-1138.
45. Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 2010, 10(6):427-439. 10.1038/nri2779, 20498669.
46. Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC, Barnes MR, Tobin F, et al. Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. DNA Cell Biol 2005, 24(7):410-431. 10.1089/dna.2005.24.410, 16008510.
47. Prucha M, Ruryk A, Boriss H, Moller E, Zazula R, Herold I, Claus RA, Reinhart KA, Deigner P, Russwurm S. Expression profiling: toward an application in sepsis diagnostics. Shock (Augusta, Ga) 2004, 22(1):29-33.
48. Talwar S, Munson PJ, Barb J, Fiuza C, Cintron AP, Logun C, Tropea M, Khan S, Reda D, Shelhamer JH, et al. Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans. Physiol Genomics 2006, 25(2):203-215. 10.1152/physiolgenomics.00192.2005, 16403844.
49. Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A. A critical role for TCF-1 in T-lineage specification and differentiation. Nature 2011, 476(7358):63-68. 10.1038/nature10279, 3156435, 21814277.
50. Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, et al. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem 2009, 284(37):24914-24924. 10.1074/jbc.M109.000059, 2757194, 19602726.
51. Wang L, Wildt KF, Castro E, Xiong Y, Feigenbaum L, Tessarollo L, Bosselut R. The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 2008, 29(6):876-887. 10.1016/j.immuni.2008.09.019, 3392968, 19062319.
52. El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Watowich SS, Hacker H, Foxwell BM, Murray PJ. Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 2007, 179(11):7215-7219.
53. Pruett SB, Schwab C, Zheng Q, Fan R. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J Immunol 2004, 173(4):2715-2724.
54. Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH, Kyriacou CP. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 2002, 12(7):540-550. 10.1016/S0960-9822(02)00759-5, 11937022.
55. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J. TM4 microarray software suite. Methods Enzymol 2006, 411:134-193.
56. Ernst J, Bar-Joseph Z. STEM: a tool for the analysis of short time series gene expression data. BMC Bioinformatics 2006, 7:191. 10.1186/1471-2105-7-191, 1456994, 16597342.