Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15437-15442

  Carmichael, Catherine L ^a,b   Metcalf, Donald ^a,b   Henley, Katya J ^a   Kruse, Elizabeth A ^a,b,c   Di Rago, Ladina ^a   Mifsud, Sandra ^a   Alexander, Warren S ^a,b   Kile, Benjamin T ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Hematopoiesis; Oncogenesis

Indexed keywords

TRANSCRIPTION FACTOR ERG;

ACUTE MEGAKARYOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; ERYTHROID CELL; ERYTHROLEUKEMIA; ERYTHROMEGAKARYOCYTIC LEUKEMIA; HEMATOPOIETIC STEM CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; ERYTHROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; LEUKEMIA; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; MICE; MICE, INBRED C57BL; ONCOGENE PROTEINS; RETROVIRIDAE; TIME FACTORS;

MURINAE; MUS;

EID: 84866554169     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1213454109     Document Type: Article

References (25)

1. Ng AP, et al. (2011) Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood 118:2454-2461.
2. Taoudi S, et al. (2011) ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 25: 251-262.
3. Loughran SJ, et al. (2008) The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9: 810-819. (Pubitemid 351859165)
4. Tomlins SA, et al. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310:644-648. (Pubitemid 41528150)
5. Tomlins SA, et al. (2008) Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia 10:177-188. (Pubitemid 351240884)
6. Klezovitch O, et al. (2008) A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci USA 105:2105-2110. (Pubitemid 351439472)
7. Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994) An RNA-binding protein gene, TLS/ FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res 54:2865-2868. (Pubitemid 24187764)
8. Sorensen PH, et al. (1994) A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6:146-151. (Pubitemid 24188594)
9. Marcucci G, et al.; Cancer and Leukemia Group B Study (2007) High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B Study. J Clin Oncol 25:3337-3343. (Pubitemid 47325620)
10. Baldus CD, et al. (2006) High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J Clin Oncol 24: 4714-4720. (Pubitemid 46630935)
11. Ng AP, et al. (2010) Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 115:3966-3969.
12. Rainis L, et al. (2005) The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res 65:7596-7602. (Pubitemid 41297231)
13. Roy A, Roberts I, Norton A, Vyas P (2009) Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: A multi-step model of myeloid leukaemogenesis. Br J Haematol 147:3-12.
14. Zipursky A (2003) Transient leukaemia - a benign form of leukaemia in newborn infants with trisomy 21. Br J Haematol 120:930-938.
15. Stankiewicz MJ, Crispino JD (2009) ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood 113:3337-3347.
16. Kirsammer G, et al. (2008) Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111:767-775.
17. Malinge S, et al. (2012) Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest 122:948-962.
18. Tsuzuki S, Taguchi O, Seto M (2011) Promotion and maintenance of leukemia by ERG. Blood 117:3858-3868.
19. Thoms JA, et al. (2011) ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood 117: 7079-7089.
20. Salek-Ardakani S, et al. (2009) ERG is a megakaryocytic oncogene. Cancer Res 69: 4665-4673.
21. Metz T, Graf T (1991) v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes. Genes Dev 5: 369-380. (Pubitemid 21905960)
22. Radke K, Beug H, Kornfeld S, Graf T (1982) Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31: 643-653. (Pubitemid 13223948)
23. Ben-David Y, Giddens EB, Letwin K, Bernstein A (1991) Erythroleukemia induction by Friend murine leukemia virus: Insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev 5:908-918. (Pubitemid 21906006)
24. Pear WS, et al. (1998) Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 92:3780-3792. (Pubitemid 28525205)
25. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87:2162-2170.