Process scale separation of an anti-CD22 immunotoxin charge variant

Journal of Chromatography A

Volumn 1260, Issue , 2012, Pages 120-125

  Linke, Thomas ^a   Feng, Jinhua ^a   Yu, Kathy ^a   Kim, Hyun Jun ^a   Wei, Ziping ^a   Wang, Yang ^a   Wang, William K ^a   Hunter, Alan K ^a  

^a MEDIMMUNE   (United States)

Author keywords

CD22; Charge variant; Deamidation; Immunotoxin; Moxetumomab pasudotox; Scale up

Indexed keywords

CD22; CHARGE VARIANT; DEAMIDATION; IMMUNOTOXINS; MOXETUMOMAB PASUDOTOX; SCALE-UP;

BIOASSAY; CHROMATOGRAPHY; ION EXCHANGE;

BIOACTIVITY;

MOXETUMOMAB PASUDOTOX;

ACCURACY; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DAUDI CELL; DEAMINATION; DRUG DETERMINATION; DRUG IMPURITY; DRUG MANUFACTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; QUALITY CONTROL; SCALE UP; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; TANDEM MASS SPECTROMETRY;

ADP RIBOSE TRANSFERASES; AMIDES; BACTERIAL TOXINS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; EXOTOXINS; HUMANS; IMMUNOTOXINS; PEPTIDE MAPPING; TANDEM MASS SPECTROMETRY; VIRULENCE FACTORS;

EID: 84866548927     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.08.061     Document Type: Article

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