Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid-lactamase display

Protein Engineering, Design and Selection

Volumn 24, Issue 4, 2011, Pages 351-360

  Bannister, D ^a   Popovic, B ^a   Sridharan, S ^a   Giannotta, F ^b   Filee P ^b   Yilmaz, N ^b   Minter, R ^a  

^a MEDIMMUNE   (United States)

^b ProGenosis SA   (Belgium)

Author keywords

beta lactamase display; CD22; epitope mapping; immunotoxin

Indexed keywords

CD22; CHARACTERISATION; CLINICAL EFFICACY; DRUG MOLECULES; EPITOPE MAPPING; GENE FRAGMENTS; IMMUNOTOXIN; IMMUNOTOXINS; LACTAMASES; PHAGE DISPLAY; STRUCTURAL COMPLEXITY; STRUCTURE ACTIVITY RELATIONSHIPS; TEST CASE; THERAPEUTIC ANTIBODIES;

AMINO ACIDS; ESCHERICHIA COLI; GENES; MAPPING; MONOCLONAL ANTIBODIES; PROTEINS;

ANTIGENS;

ALANINE; AMPICILLIN; BETA LACTAMASE; CD22 ANTIGEN; IMMUNOTOXIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CAT 8015; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; EPITOPE MAPPING; ESCHERICHIA COLI; GENE INSERTION; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING;

AMINO ACID SEQUENCE; ANTIGENS, CD22; BACTERIAL TOXINS; BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; EXOTOXINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

ESCHERICHIA COLI;

EID: 79952645843     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq114     Document Type: Article

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