Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: The effects of ageing and sex

Mechanisms of Ageing and Development

Volumn 133, Issue 9-10, 2012, Pages 591-599

  Jeevaratnam, Kamalan ^a,c   Rewbury, Rebecca ^a   Zhang, Yanmin ^a,b   Guzadhur, Laila ^a   Grace, Andrew A ^a   Lei, Ming ^d   Huang, Christopher L H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c PERDANA UNIVERSITY   (Malaysia)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Brugada syndrome; Conduction defects; Fibrosis; Genetically modified hearts; Multi array recording; Overlap syndrome; Progressive cardiac conduction defect; Sodium channel

Indexed keywords

SODIUM CHANNEL NAV1.5;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUGADA SYNDROME; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; GENDER; GENE; GENETIC ANALYSIS; GENOTYPE; HEART BUNDLE BRANCH BLOCK; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE FIBROSIS; INCIDENCE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGRESSIVE CARDIAC CONDUCTION DEFECT; SCN5A GENE; SEX DIFFERENCE;

AGING; ANIMALS; BRUGADA SYNDROME; ENDOMYOCARDIAL FIBROSIS; FEMALE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MALE; MICE; MICE, MUTANT STRAINS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; SEX CHARACTERISTICS;

MURINAE; MUS;

EID: 84866540406     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2012.07.006     Document Type: Article

References (23)

1. Antzelevitch C. Brugada syndrome: historical perspectives and observations. European Heart Journal 2002, 23:676-678.
2. Brugada P., Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. Journal of the American College of Cardiology 1992, 20:1391-1396.
3. Catalano O., Antonaci S., Moro G., Mussida M., Frascaroli M., Baldi M., Cobelli F., Baiardi P., Nastoli J., Bloise R., Monteforte N., Napolitano C., Priori S.G. Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities. European Heart Journal 2009, 30:2241-2248.
4. Chu D.K., Jordan M.C., Kim J.K., Couto M.A., Roos K.P. Comparing isoflurane with tribromoethanol anesthesia for echocardiographic phenotyping of transgenic mice. Journal of the American Association for Laboratory Animal Science 2006, 45:8-13.
5. Frustaci A., Priori S.G., Pieroni M., Chimenti C., Napolitano C., Rivolta I., Sanna T., Bellocci F., Russo M.A. Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation 2005, 112:3680-3687.
6. Guzadhur L., Pearcey S.M., Duehmke R.M., Jeevaratnam K., Hohmann A.F., Zhang Y., Grace A.A., Lei M., Huang C.L. Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction. Pflugers Archiv 2010, 460:593-601.
7. Hart C.Y., Burnett J.C., Redfield M.M. Effects of avertin versus xylazine-ketamine anesthesia on cardiac function in normal mice. American Journal of Physiology - Heart and Circulatory Physiology 2001, 281:H1938-H1945.
8. Hermida J.S., Lemoine J.L., Aoun F.B., Jarry G., Rey J.L., Quiret J.C. Prevalence of the brugada syndrome in an apparently healthy population. American Journal of Cardiology 2000, 86:91-94.
9. Hoogendijk M.G., Opthof T., Postema P.G., Wilde A.A., de Bakker J.M., Coronel R. The Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome. Circulation Arrhythmia and Electrophysiology 2010, 3:283-290.
10. Hoogendijk M.G., Potse M., Linnenbank A.C., Verkerk A.O., den Ruijter H.M., van Amersfoorth S.C., Klaver E.C., Beekman L., Bezzina C.R., Postema P.G., Tan H.L., Reimer A.G., van der Wal A.C., Ten Harkel A.D., Dalinghaus M., Vinet A., Wilde A.A., de Bakker J.M., Coronel R. Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm 2010, 7:238-248.
11. Jeevaratnam K., Poh Tee S., Zhang Y., Rewbury R., Guzadhur L., Duehmke R., Grace A.A., Lei M., Huang C.L. Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex. Pflugers Archiv 2011, 461:29-44.
12. Jeevaratnam K., Zhang Y., Guzadhur L., Duehmke R.M., Lei M., Grace A.A., Huang C.L. Differences in sino-atrial and atrio-ventricular function with age and sex attributable to the Scn5a+/- mutation in a murine cardiac model. Acta Physiologica (Oxford) 2010, 200:23-33.
13. Kiatchoosakun S., Kirkpatrick D., Hoit B.D. Effects of tribromoethanol anesthesia on echocardiographic assessment of left ventricular function in mice. Comparative Medicine 2001, 51:26-29.
14. Leoni A.L., Gavillet B., Rougier J.S., Marionneau C., Probst V., Le Scouarnec S., Schott J.J., Demolombe S., Bruneval P., Huang C.L., Colledge W.H., Grace A.A., Le Marec H., Wilde A.A., Mohler P.J., Escande D., Abriel H., Charpentier F. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. PLoS One 2010, 5:e9298.
15. Ohkubo K., Watanabe I., Okumura Y., Takagi Y., Ashino S., Kofune M., Sugimura H., Nakai T., Kasamaki Y., Hirayama A., Morimoto S. Right ventricular histological substrate and conduction delay in patients with Brugada syndrome. International Heart Journal 2010, 51:17-23.
16. Priori S.G., Napolitano C., Gasparini M., Pappone C., Della Bella P., Brignole M., Giordano U., Giovannini T., Menozzi C., Bloise R., Crotti L., Terreni L., Schwartz P.J. Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: a prospective evaluation of 52 families. Circulation 2000, 102:2509-2515.
17. Royer A., van Veen T.A., Le Bouter S., Marionneau C., Griol-Charhbili V., Leoni A.L., Steenman M., van Rijen H.V., Demolombe S., Goddard C.A., Richer C., Escoubet B., Jarry-Guichard T., Colledge W.H., Gros D., de Bakker J.M., Grace A.A., Escande D., Charpentier F. Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis. Circulation 2005, 111:1738-1746.
18. Sacher F., Meregalli P., Veltmann C., Field M.E., Solnon A., Bru P., Abbey S., Jais P., Tan H.L., Wolpert C., Lande G., Bertault V., Derval N., Babuty D., Lacroix D., Boveda S., Maury P., Hocini M., Clementy J., Mabo P., Lemarec H., Mansourati J., Borggrefe M., Wilde A., Haissaguerre M., Probst V. Are women with severely symptomatic Brugada syndrome different from men?. Journal of Cardiovascular Electrophysiology 2008, 19:1181-1185.
19. Schott J.J., Alshinawi C., Kyndt F., Probst V., Hoorntje T.M., Hulsbeek M., Wilde A.A., Escande D., Mannens M.M., Le Marec H. Cardiac conduction defects associate with mutations in SCN5A. Nature Genetics 1999, 23:20-21.
20. Smits J.P., Eckardt L., Probst V., Bezzina C.R., Schott J.J., Remme C.A., Haverkamp W., Breithardt G., Escande D., Schulze-Bahr E., LeMarec H., Wilde A.A. Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. Journal of the American College of Cardiology 2002, 40:350-356.
21. Stokoe K.S., Balasubramaniam R., Goddard C.A., Colledge W.H., Grace A.A., Huang C.L. Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome. Journal of Physiology 2007, 581:255-275.
22. van Veen T.A., Stein M., Royer A., Le Quang K., Charpentier F., Colledge W.H., Huang C.L., Wilders R., Grace A.A., Escande D., de Bakker J.M., van Rijen H.V. Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation 2005, 112:1927-1935.
23. Wilde A.A., Postema P.G., Di Diego J.M., Viskin S., Morita H., Fish J.M., Antzelevitch C. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. Journal of Molecular and Cellular Cardiology 2010, 49:543-553.