Right ventricular histological substrate and conduction delay in patients with Brugada syndrome

International Heart Journal

Volumn 51, Issue 1, 2010, Pages 17-23

  Ohkubo, Kimie ^a   Watanabe, Ichiro ^a   Okumura, Yasuo ^a   Takagi, Yasuhiro ^a   Ashino, Sonoko ^a   Kofune, Masayoshi ^a   Sugimura, Hidezou ^a   Nakai, Toshiko ^a   Kasamaki, Yuji ^a   Hirayama, Atsushi ^a   Morimoto, Shin Ichiro ^b  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Brugada syndrome; Delayed potential; Electrophysiologic study; RV biopsy

Indexed keywords

AMIODARONE; CIBENZOLINE; PILSICAINIDE;

ADIPOSE TISSUE; ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BRUGADA SYNDROME; CLINICAL ARTICLE; DEFIBRILLATOR; ELECTROCARDIOGRAPHY; FEMALE; HEART CATHETERIZATION; HEART CONDUCTION; HEART MUSCLE BIOPSY; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE OUTFLOW TRACT; HEART STIMULATION; HEART VENTRICLE FIBRILLATION; HISTOLOGY; HUMAN; HUMAN TISSUE; LYMPHOCYTIC INFILTRATION; MALE; MUSCLE CELL; PRIORITY JOURNAL;

ADULT; AGED; BRUGADA SYNDROME; CORONARY ANGIOGRAPHY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; HEART; HEART CATHETERIZATION; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM;

EID: 76749121838     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.51.17     Document Type: Article

References (50)

1. Brugada P. Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992; 20: 1391-6.
2. Antzelevitch C, Brugada P, Brugada J, et al. Brugada syndrome: a decade of progress. Circ Res 2002; 91: 1114-8. (Review)
3. Chen Q, Kirsch GE, Zhang D, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998; 392: 293-6.
4. Priori SG, Napolitano C, Gasparini M, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation 2002; 105: 1342-7.
5. Li GR, Feng J, Yue L, Carrier M. Transmural heterogeneity of action potentials and Itol in myocytes isolated from the human right ventricle. Am J Physiol 1998; 275: H369-77.
6. Corrado D, Basso C, Buja G, Nava A, Rossi L, Thiene G. Right bundle branch block, right precordial st-segment elevation, and sudden death in young people. Circulation 2001; 103: 710-7.
7. Nagase S, Kusano KF, Morita H, et al. Epicardial electrogram of the right ventricular outflow tract in patients with the Brugada syndrome: using the epicardial lead. J Am Coll Cardiol 2002; 39: 1992-5.
8. Tukkie R, Sogaard P, Vleugels J, de Groot IK, Wilde AA, Tan HL. Delay in right ventricular activation contributes to Brugada syndrome. Circulation 2004; 109: 1272-7.
9. Kasanuki H, Ohnishi S, Ohtsuka M, et al. Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease. Circulation 1997; 95: 2277-85.
10. Coronel R, Casini S, Koopmann TT, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005; 112: 2769-77.
11. Meregalli PG, Wilde AA, Tan HL. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? Cardiovasc Res 2005; 67: 367-78. (Review)
12. Wilde AA, Antzelevitch C, Borggrefe M, et al. Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J 2002; 23: 1648-54. (Review)
13. Ikeda T, Sakurada H, Sakabe K, et al. Assessment of noninvasive markers in identifying patients at risk in the Brugada syndrome: insight into risk stratification. J Am Coll Cardiol 2001; 37: 1628-34.
14. Masaki R, Watanabe I, Nakai T, et al. Role of signal-averaged electrocardiograms for predicting the inducibility of ventricular fibrillation in the syndrome consisting of right bundle branch block and ST segment elevation in leads V1-V3. Jpn Heart J 2002; 43: 367-78.
15. Brugada P, Green M, Abdullah H, Wellens HJ. Significance of ventricular arrhythmias initiated by programmed ventricular stimulation: the importance of the type of ventricular arrhythmia induced and the number of premature stimuli required. Circulation 1984; 69: 87-92.
16. Shimizu W, Antzelevitch C, Suyama K, et al. Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2000; 11: 1320-9.
17. Morita H, Morita ST, Nagase S, et al. Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome. J Am Coll Cardiol 2003; 42: 1624-31.
18. Chinushi M, Komura S, Izumi D, et al. Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome. Pacing Clin Electrophysiol 2007; 30: 662-71.
19. Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 2004; 110: 1731-7. (Review)
20. Morimoto S, Uemura A, Watanabe E, et al. A multicentre histological study of autopsied and biopsied specimens in Brugada syndrome. Eur Heart J 2003; 24(Suppl): 147.
21. Corrado D, Nava A, Buja G, et al. Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. J Am Coll Cardiol 1996: 27: 443-8.
22. Tada H, Aihara N, Ohe T, et al. Arrhythmogenic right ventricular cardiomyopathy underlies syndrome of right bundle branch block, ST-segment elevation, and sudden death. Am J Cardiol 1998; 81: 519-22.
23. Morgera T, Sinagra GF, Viel E, Ricci C, Bussani R, Camerini F. The syndrome of right bundle branch block, persistent ST segment elevation and sudden cardiac death. Which is the histological substrate? Eur Heart J 1997; 18: 1190-1.
24. Corrado D, Basso C, Buja GF, Nava A. Thiene G. Electrocardiographic and pathologic correlations in the syndrome of right bundle-branch block, right precordial ST-segment elevation, and sudden death. Eur Heart J 1998; 19(Suppl): 577.
25. Izumi T, Ajiki K, Nozaki A, et al. Right ventricular cardiomyopathy showing right bundle branch block and right precordial ST segment elevation. Intern Med 2000; 39: 28-33.
26. Wichter T, Meyborg M, Paul M, et al. Autonomic dysfunction in Brugada syndrome: New evidence for impaired adrenergic stimulation from biochemical analyses of endomyocardial biopsies. Heart Rhythm 2004; 1(Suppl): S124.
27. Pérez Riera AR, Antzelevitch C, Schapacknik E, Dubner S, Ferreira C. Is there an overlap between Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy/dysplasia? J Electrocardiol 2005; 38: 260-3. (Review)
28. Frustaci A, Priori SG, Pieroni M, et al. Cardiac histopathologic substrate in patients with clinical phenotype of Brugada syndrome. Circulation 2005; 112: 3680-7.
29. Zumhagen S, Spieker T, Rolinck J, et al. Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome. Circ Arrhythmia Electtophysiol 2009; 2: 16-23.
30. Morimoto S, Uemura A, Hishida H. An autopsy case of Brugada syndrome with significant lesions in the sinus node. J Cardiovasc Electrophysiol 2005; 16: 345-7.
31. Corrado D, Basso C, Buja G, Nava A, Rossi L, Thiene G. Right bundle branch block, right precordial st-segment elevation, and sudden death in young people. Circulation 2001; 103: 710-7.
32. Hoogendijk MG, Potse M, Linnenbank AC, et al. Brugada-type ST segment elevation after sodium channel blockade is caused by right ventricular excitation failure in discontinuous myocardium. Circulation 2008; 118: S-982.
33. Papadatos GA, Wallerstein PM, Head CE, et al. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A 2002; 99: 6210-5.
34. Royer A, van Veen TA, Le Bouter S, et al. Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis. Circulation 2005; 111: 1738-46.
35. Pieske B, Houser SR, Hasenfuss G, Bers DM. Sodium and the heart: a hidden key factor in cardiac regulation. Cardiovasc Res 2003; 57: 871-2.
36. + regulation in cardiac myocytes. Cardiovasc Res 2003; 57: 897-912. (Review)
37. Eckardt L, Kirchhof P, Schulze-Bahr E, et al. Electrophysiologic investigation in Brugada syndrome; yield of programmed ventricular stimulation at two ventricular sites with up to three premature beats. Eur Heart J 2002; 23: 1394-401.
38. Ohkubo K, Watanabe I, Takagi Y, et al. Electrocardiographic and electrophysiologic characteristics in patients with Brugada type electrocardiogram and inducible ventricular fibrillation: single center experience. Circ J 2007; 71: 1437-41.
39. Morita H, Fukushima-Kusano K, Nagase S, et al. Site-specific arrhythmogenesis in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2003; 14: 373-9.
40. Ohkubo K, Watanabe I, Takagi Y, et al. Surface and intracardiac electrogram characteristics of induced ventricular tachyarrhythmias before degenerating into ventricular fibrillation in Brugada syndrome. Heart Rhythm 2007; 4(Suppl): S196.
41. Ohkubo K, Watanabe I, Takagi Y, et al. Endocardial electrograms from the right ventricular outflow tract after induced ventricular fibrillation in patients with Brugada syndrome. Circ J 2007; 71: 1258-62.
42. Haissaguerre M, Extramiana F, Hocini M, et al. Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes. Circulation 2003; 108: 925-8.
43. Takagi M, Aihara N, Kuribayashi S, et al. Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome. Eur Heart J 2001; 22: 1032-41.
44. Takagi M, Aihara N, Kuribayashi S, et al. Abnormal response to sodium channel blockers in patients with Brugada syndrome: augmented localized wall motion abnormalities in the right ventricular outflow tract region detected by electron beam computed tomography. Heart 2003: 89: 169-74.
45. Sato Y, Kato K, Hashimoto M, et al. Localized right ventricular structural abnormalities in patients with idiopathic ventricular fibrillation: magnetic resonance imaging study. Heart Vessels 1996; 11: 100-3.
46. Alix D, Mairesse D, Lacroix D. et al. Right bundle-branch block with ST-segment elevation: evidence for an underlying pathological substrate. Eur Heart J 2003; 24: 195.
47. Papavassiliu T, Wolpert C, Flüchter S, et al. Magnetic resonance imaging findings in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2004: 15: 1133-8.
48. Nagahara D, Uno K, Shimoshige S, et al. Focal myocardial arrhythmogenic substrates detected in Brugada syndrome can conttibute to characteristic propagating mode of induced ventricular fibrillation. Circ J 2003; 67 (Suppl 1): 104.
49. Corrado D, Basso C, Thiene G. Is it time to include ion channel diseases among cardiomyopathies? J Electrocardiol 2005; 38: 81-7. (Review)
50. Postema PG, van Dessel PF, de Bakker JM, et al. Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study. Circ Arrhythmia Electrophysiol 2008; 1: 379-86.