Atrial arrhythmogenicity in aged Scn5a+/ΔKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction

Pflugers Archiv European Journal of Physiology

Volumn 460, Issue 3, 2010, Pages 593-601

  Guzadhur, Laila ^a   Pearcey, Sarah M ^a   Duehmke, Rudolf M ^a   Jeevaratnam, Kamalan ^a   Hohmann, Anja F ^a   Zhang, Yanmin ^a   Grace, Andrew A ^a   Lei, Ming ^b   Huang, Christopher L H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Age; Arrhythmia; Atrial arrhythmogenicity; Electrophysiology; Excitation; Genetically modified mice; LQT3 syndrome; Mouse; Na channels; Sodium channel

Indexed keywords

SODIUM CHANNEL; SODIUM CHANNEL NAV1.5; SCN5A PROTEIN, HUMAN; SCN5A PROTEIN, MOUSE;

ACTION POTENTIAL; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; GENETIC VARIABILITY; GENOTYPE; HEART ATRIUM ARRHYTHMIA; HEART CONDUCTION; HEART MUSCLE REFRACTORY PERIOD; HEART RATE; LONG QT SYNDROME; MOUSE; NONHUMAN; PHENOTYPE; PR INTERVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; GENETICS; HEART ATRIUM FIBRILLATION; HEART MUSCLE CONDUCTION SYSTEM; METABOLISM; MUTATION; PHYSIOLOGY;

ACTION POTENTIALS; AGING; ANIMALS; ATRIAL FIBRILLATION; ELECTROCARDIOGRAPHY; GENOTYPE; HEART CONDUCTION SYSTEM; LONG QT SYNDROME; MICE; MUTATION; PHENOTYPE; SODIUM CHANNELS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL;

EID: 77955467926     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0851-z     Document Type: Article

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