Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3′-terminal phosphate and 5′-OH

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15235-15240

  Englert, Markus ^a   Xia, Shuangluo ^a   Okada, Chiaki ^b   Nakamura, Akiyoshi ^a   Tanavde, Ved ^a   Yao, Min ^b   Eom, Soo Hyun ^c   Konigsberg, William H ^a   Sol̈l, Dieter ^a   Wang, Jimin ^a  

^a YALE UNIVERSITY   (United States)

^b HOKKAIDO UNIVERSITY   (Japan)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

RNA repair; tRNA splicing; Two metal ion catalysis

Indexed keywords

HYDROXYL GROUP; MANGANESE; PHOSPHATE; RNA LIGASE; RTCB PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; GUANYLYLATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PYROCOCCUS HORIKOSHII; RNA SPLICING;

AMINO ACYL-TRNA SYNTHETASES; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CYCLIC GMP; ESCHERICHIA COLI PROTEINS; GUANOSINE TRIPHOSPHATE; IONS; MANGANESE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POLYNUCLEOTIDE LIGASES; PROTEIN BINDING; PYROCOCCUS HORIKOSHII; RNA SPLICING; RNA, TRANSFER; SUBSTRATE SPECIFICITY; SULFATES;

PYROCOCCUS HORIKOSHII;

EID: 84866540193     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1213795109     Document Type: Article

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