Novel insights into cyclooxygenases, linoleate diol synthases, and lipoxygenases from deuterium kinetic isotope effects and oxidation of substrate analogs

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 12, 2012, Pages 1508-1517

  Hoffmann, Inga ^a   Hamberg, Mats ^b   Lindh, Roland ^c   Oliw, Ernst H ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Animal heme peroxidase; Chiral phase HPLC; Fatty acid oxygenation; Kinetic isotope effect; Mass spectrometry; Oxygenation mechanism

Indexed keywords

CARBON; DEUTERIUM; ENZYME; FATTY ACID; HYDROGEN; ISOTOPE; LINOLEATE DIOL SYNTHASE; LIPOXYGENASE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ISOMER; MASS SPECTROMETRY; OXIDATION; OXYGENATION; PRIORITY JOURNAL;

BIOCATALYSIS; CHROMATOGRAPHY, LIQUID; DEUTERIUM; FATTY ACIDS, UNSATURATED; ISOMERISM; KINETICS; LIPOXYGENASES; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXYGEN; OXYGENASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SUBSTRATE SPECIFICITY; TIME FACTORS;

ANIMALIA; GLYCINE MAX;

EID: 84866530943     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.09.001     Document Type: Article

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