-
1
-
-
48449101742
-
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
-
Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008;14:135-45.
-
(2008)
Cancer Cell
, vol.14
, pp. 135-145
-
-
Yang, Z.J.1
Ellis, T.2
Markant, S.L.3
-
2
-
-
48449105147
-
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
-
Schuller U, Heine VM, Mao J, et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008;14:123-34.
-
(2008)
Cancer Cell
, vol.14
, pp. 123-134
-
-
Schuller, U.1
Heine, V.M.2
Mao, J.3
-
4
-
-
20944435474
-
Wnt signaling: Multiple functions in neural development
-
Ille F, Sommer L. Wnt signaling: multiple functions in neural development. Cell Mol Life Sci 2005;62:1100-8.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 1100-1108
-
-
Ille, F.1
Sommer, L.2
-
5
-
-
33847740988
-
Wnt/β-catenin signaling in cancer stemness and malignant behavior
-
Fodde R, Brabletz T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007;19:150-8.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 150-158
-
-
Fodde, R.1
Brabletz, T.2
-
6
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
Sparks, A.B.2
Rago, C.3
-
7
-
-
0033119801
-
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6.
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
8
-
-
33644513730
-
Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
9
-
-
33744827377
-
Phosphatidylinositol 3′-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN
-
Hartmann W, Digon-Sontgerath B, Koch A, et al. Phosphatidylinositol 3′-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res 2006;12:3019-27.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3019-3027
-
-
Hartmann, W.1
Digon-Sontgerath, B.2
Koch, A.3
-
10
-
-
34250788809
-
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74.
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74.
-
-
-
-
11
-
-
39449135834
-
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
-
Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 2008;22:436-48.
-
(2008)
Genes Dev
, vol.22
, pp. 436-448
-
-
Hambardzumyan, D.1
Becher, O.J.2
Rosenblum, M.K.3
Pandolfi, P.P.4
Manova-Todorova, K.5
Holland, E.C.6
-
13
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
14
-
-
56149086145
-
Tumorgrowth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets
-
Baryawno N, Sveinbjornsson B, Eksborg S, et al. Tumorgrowth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro-oncol 2008;10:661-74.
-
(2008)
Neuro-oncol
, vol.10
, pp. 661-674
-
-
Baryawno, N.1
Sveinbjornsson, B.2
Eksborg, S.3
-
15
-
-
42949133285
-
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
-
Johnsen JI, Segerstrom L, Orrego A, et al. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 2008.
-
(2008)
Oncogene
-
-
Johnsen, J.I.1
Segerstrom, L.2
Orrego, A.3
-
16
-
-
5644294350
-
Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo
-
Johnsen JI, Lindskog M, Ponthan F, et al. Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. Cancer Res 2004;64:7210-5.
-
(2004)
Cancer Res
, vol.64
, pp. 7210-7215
-
-
Johnsen, J.I.1
Lindskog, M.2
Ponthan, F.3
-
17
-
-
33847407482
-
Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo
-
Ponthan F, Wickstrom M, Gleissman H, et al. Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. Clin Cancer Res 2007; 13:1036-44.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1036-1044
-
-
Ponthan, F.1
Wickstrom, M.2
Gleissman, H.3
-
18
-
-
3042562279
-
From the cyclooxygenase-2 in-hibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
-
Zhu J, Huang JW, Tseng PH, et al. From the cyclooxygenase-2 in-hibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res 2004;64:4309-18.
-
(2004)
Cancer Res
, vol.64
, pp. 4309-4318
-
-
Zhu, J.1
Huang, J.W.2
Tseng, P.H.3
-
19
-
-
4444273153
-
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
-
Rao G, Pedone CA, Valle LD, Reiss K, Holland EC, Fults DW. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 2004;23:6156-62.
-
(2004)
Oncogene
, vol.23
, pp. 6156-6162
-
-
Rao, G.1
Pedone, C.A.2
Valle, L.D.3
Reiss, K.4
Holland, E.C.5
Fults, D.W.6
-
20
-
-
0036948033
-
-
Del Valle L,Wang JY, Lassak A, et al. Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors-medulloblastomas. J Neurovirol 2002;8Suppl 2:138-47.
-
Del Valle L,Wang JY, Lassak A, et al. Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors-medulloblastomas. J Neurovirol 2002;8Suppl 2:138-47.
-
-
-
-
22
-
-
48049090471
-
Implication of active Erk in the classic type of human medulloblastoma
-
Wlodarski PK, Boszczyk A, Grajkowska W, Roszkowski M, Jozwiak J. Implication of active Erk in the classic type of human medulloblastoma. Folia Neuropathol 2008;46:117-22.
-
(2008)
Folia Neuropathol
, vol.46
, pp. 117-122
-
-
Wlodarski, P.K.1
Boszczyk, A.2
Grajkowska, W.3
Roszkowski, M.4
Jozwiak, J.5
-
23
-
-
34147125432
-
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
-
Urbanska K, Trojanek J, Del Valle L, et al. Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines. Oncogene 2007;26:2308-17.
-
(2007)
Oncogene
, vol.26
, pp. 2308-2317
-
-
Urbanska, K.1
Trojanek, J.2
Del Valle, L.3
-
24
-
-
0242361321
-
PDGFRB is overexpressed in metastatic medulloblastoma
-
Gilbertson RJ, Clifford SC. PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 2003;35:197-8.
-
(2003)
Nat Genet
, vol.35
, pp. 197-198
-
-
Gilbertson, R.J.1
Clifford, S.C.2
-
25
-
-
0034794796
-
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
-
MacDonald TJ, Brown KM, LaFleur B, et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 2001;29:143-52.
-
(2001)
Nat Genet
, vol.29
, pp. 143-152
-
-
MacDonald, T.J.1
Brown, K.M.2
LaFleur, B.3
-
26
-
-
0030091609
-
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system
-
Washiyama K, Muragaki Y, Rorke LB, et al. Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. Am J Pathol 1996;148:929-40.
-
(1996)
Am J Pathol
, vol.148
, pp. 929-940
-
-
Washiyama, K.1
Muragaki, Y.2
Rorke, L.B.3
-
27
-
-
0036962461
-
Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro
-
Barbero S, Bajetto A, Bonavia R, et al. Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro. Ann N Y Acad Sci 2002;973:60-9.
-
(2002)
Ann N Y Acad Sci
, vol.973
, pp. 60-69
-
-
Barbero, S.1
Bajetto, A.2
Bonavia, R.3
-
28
-
-
9344240453
-
A clinicobiological model predicting survival in medulloblastoma
-
Ray A, Ho M, Ma J, et al. A clinicobiological model predicting survival in medulloblastoma. Clin Cancer Res 2004;10:7613-20.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7613-7620
-
-
Ray, A.1
Ho, M.2
Ma, J.3
-
29
-
-
16644398737
-
C-kit expression and mutational analysis in medulloblastoma
-
Chilton-Macneill S, Ho M, Hawkins C, Gassas A, Zielenska M, Baruchel S. C-kit expression and mutational analysis in medulloblastoma. Pediatr Dev Pathol 2004;7:493-8.
-
(2004)
Pediatr Dev Pathol
, vol.7
, pp. 493-498
-
-
Chilton-Macneill, S.1
Ho, M.2
Hawkins, C.3
Gassas, A.4
Zielenska, M.5
Baruchel, S.6
-
30
-
-
51849098272
-
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
-
Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008;27: 5511-26.
-
(2008)
Oncogene
, vol.27
, pp. 5511-5526
-
-
Garcia-Echeverria, C.1
Sellers, W.R.2
-
31
-
-
0037099658
-
Essential role of PDK1 in regulating cell size and development in mice
-
Lawlor MA, Mora A, Ashby PR, et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J 2002;21: 3728-38.
-
(2002)
EMBO J
, vol.21
, pp. 3728-3738
-
-
Lawlor, M.A.1
Mora, A.2
Ashby, P.R.3
-
32
-
-
33745238704
-
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 in-hibitors
-
Grosch S, Maier TJ, Schiffmann S, Geisslinger G. Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 in-hibitors. J Natl Cancer Inst 2006;98:736-47.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 736-747
-
-
Grosch, S.1
Maier, T.J.2
Schiffmann, S.3
Geisslinger, G.4
-
33
-
-
15244342640
-
A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism
-
Johnson AJ, Smith LL, Zhu J, et al. A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism. Blood 2005;105:2504-9.
-
(2005)
Blood
, vol.105
, pp. 2504-2509
-
-
Johnson, A.J.1
Smith, L.L.2
Zhu, J.3
-
34
-
-
33746238112
-
OSU-03012 promotes caspaseindependent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells
-
Yacoub A, Park MA, Hanna D, et al. OSU-03012 promotes caspaseindependent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Mol Pharmacol 2006;70:589-603.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 589-603
-
-
Yacoub, A.1
Park, M.A.2
Hanna, D.3
-
35
-
-
34548060313
-
OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms
-
Zhang S, Suvannasankha A, Crean CD, et al. OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. Clin Cancer Res 2007;13:4750-8.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4750-4758
-
-
Zhang, S.1
Suvannasankha, A.2
Crean, C.D.3
-
36
-
-
56449127196
-
OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma
-
Gao M, Yeh PY, Lu YS, et al. OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res 2008;68:9348-57.
-
(2008)
Cancer Res
, vol.68
, pp. 9348-9357
-
-
Gao, M.1
Yeh, P.Y.2
Lu, Y.S.3
-
37
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
Nogueira V, Park Y, Chen CC, et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008; 14:458-70.
-
(2008)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
-
38
-
-
58149252480
-
Targeting the PI3K p110α isoform inhibits medulloblastoma proliferation, chemoresistance, and migration
-
Guerreiro AS, Fattet S, Fischer B, et al. Targeting the PI3K p110α isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res 2008;14:6761-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6761-6769
-
-
Guerreiro, A.S.1
Fattet, S.2
Fischer, B.3
-
39
-
-
36049023679
-
Phase I study of everolimus in pediatric patients with refractory solid tumors
-
Fouladi M, Laningham F, Wu J, et al. Phase I study of everolimus in pediatric patients with refractory solid tumors. J Clin Oncol 2007;25: 4806-12.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4806-4812
-
-
Fouladi, M.1
Laningham, F.2
Wu, J.3
-
40
-
-
0035866358
-
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
-
Geoerger B, Kerr K, Tang CB, et al. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 2001;61:1527-32.
-
(2001)
Cancer Res
, vol.61
, pp. 1527-1532
-
-
Geoerger, B.1
Kerr, K.2
Tang, C.B.3
-
41
-
-
0037473082
-
AXIN1 mutations but not deletions in cerebellar medulloblastomas
-
Baeza N, Masuoka J, Kleihues P, Ohgaki H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003;22:632-6.
-
(2003)
Oncogene
, vol.22
, pp. 632-636
-
-
Baeza, N.1
Masuoka, J.2
Kleihues, P.3
Ohgaki, H.4
-
42
-
-
0034033921
-
Nuclear localization and mutation of β-catenin in medulloblastomas
-
Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of β-catenin in medulloblastomas. J Neuropathol Exp Neurol 2000; 59:333-7.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 333-337
-
-
Eberhart, C.G.1
Tihan, T.2
Burger, P.C.3
-
44
-
-
32944461274
-
β-Catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
-
Ellison DW, Onilude OE, Lindsey JC, et al. β-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 2005;23:7951-7.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7951-7957
-
-
Ellison, D.W.1
Onilude, O.E.2
Lindsey, J.C.3
-
45
-
-
0035843148
-
Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation
-
Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, et al. Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation. Oncogene 2001;20:252-9.
-
(2001)
Oncogene
, vol.20
, pp. 252-259
-
-
Desbois-Mouthon, C.1
Cadoret, A.2
Blivet-Van Eggelpoel, M.J.3
-
46
-
-
0345736990
-
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
-
Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 2003;4:499-515.
-
(2003)
Cancer Cell
, vol.4
, pp. 499-515
-
-
Lu, Z.1
Ghosh, S.2
Wang, Z.3
Hunter, T.4
-
47
-
-
0035899466
-
IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition
-
Morali OG, Delmas V, Moore R, Jeanney C, Thiery JP, Larue L. IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene 2001;20:4942-50.
-
(2001)
Oncogene
, vol.20
, pp. 4942-4950
-
-
Morali, O.G.1
Delmas, V.2
Moore, R.3
Jeanney, C.4
Thiery, J.P.5
Larue, L.6
-
48
-
-
75149120696
-
-
Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51. 49. Gilbertson RJ. Medulloblastoma: signalling a change in treatment. Lancet Oncol 2004;5:209-18.
-
Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51. 49. Gilbertson RJ. Medulloblastoma: signalling a change in treatment. Lancet Oncol 2004;5:209-18.
-
-
-
-
49
-
-
30944461586
-
PTEN and GSK3β: Key regulators of progression to androgen-independent prostate cancer
-
Mulholland DJ, Dedhar S, Wu H, Nelson CC. PTEN and GSK3β: key regulators of progression to androgen-independent prostate cancer. Oncogene 2006;25:329-37.
-
(2006)
Oncogene
, vol.25
, pp. 329-337
-
-
Mulholland, D.J.1
Dedhar, S.2
Wu, H.3
Nelson, C.C.4
|