Caspase 2 Activation and ER Stress Drive Rapid Jurkat Cell Apoptosis by Clofibrate

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Penna, Fabio ^a   Pin, Fabrizio ^a   Costamagna, Domiziana ^a   Reffo, Patrizia ^a   Baccino, Francesco Maria ^a   Bonelli, Gabriella ^a   Costelli, Paola ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALPAIN; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CLOFIBRATE; INITIATION FACTOR 2ALPHA; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 2; CLOFIBRATE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMANS; JURKAT CELLS;

RATTUS;

EID: 84866504034     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045327     Document Type: Article

References (55)

1. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W, (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha,-beta, and-gamma in the adult rat. Endocrinology 137: 354-366.
2. Xu HE, Li Y, (2008) Ligand-dependent and-independent regulation of PPAR gamma and orphan nuclear receptors. Sci Signal 1: pe52.
3. Lai DY, (2004) Rodent carcinogenicity of peroxisome proliferators and issues on human relevance. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 22: 37-55.
4. Reddy JK, Rao S, Moody DE, (1976) Hepatocellular carcinomas in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator. Cancer Res 36: 1211-1217.
5. Ohmura T, Ledda-Columbano GM, Piga R, Columbano A, Glemba J, et al. (1996) Hepatocyte proliferation induced by a single dose of a peroxisome proliferator. Am J Pathol 148: 815-824.
6. Lake BG, Rumsby PC, Price RJ, Cunninghame ME, (2000) Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig. Mutat Res 448: 213-225.
7. Luci S, Giemsa B, Hause G, Kluge H, Eder K, (2007) Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents. BMC Pharmacol 7: 6.
8. Peters JM, Cheung C, Gonzalez FJ, (2005) Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? J Mol Med (Berl) 83: 774-785.
9. Nishimura J, Dewa Y, Muguruma M, Kuroiwa Y, Yasuno H, et al. (2007) Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats. Toxicol Sci 97: 44-54.
10. Peters JM, Cattley RC, Gonzalez FJ, (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis 18: 2029-2033.
11. Bentley P, Calder I, Elcombe C, Grasso P, Stringer D, et al. (1993) Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem Toxicol 31: 857-907.
12. Scatena R, Bottoni P, Giardina B, (2008) Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key? PPAR Res 2008: 256251.
13. Canuto RA, Muzio G, Maggiora M, Autelli R, Barbiero G, et al. (1997) Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro. Cell Death Differ 4: 224-232.
14. Shabalina IG, Panaretakis T, Bergstrand A, DePierre JW, (1999) Effects of the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid, on apoptosis in human hepatoma HepG2 cells. Carcinogenesis 20: 2237-2246.
15. Simbula G, Pibiri M, Sanna L, Cossu C, Molotzu F, et al. (2004) The peroxisome proliferator BR931 kills FaO cells by p53-dependent apoptosis. Life Sci 75: 271-286.
16. Xiao S, Anderson SP, Swanson C, Bahnemann R, Voss KA, et al. (2006) Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver. Toxicol Sci 92: 368-377.
17. Elstner E, Muller C, Koshizuka K, Williamson EA, Park D, et al. (1998) Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci U S A 95: 8806-8811.
18. Tsubouchi Y, Sano H, Kawahito Y, Mukai S, Yamada R, et al. (2000) Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun 270: 400-405.
19. Muzio G, Martinasso G, Trombetta A, Di Simone D, Canuto RA, et al. (2006) HMG-CoA reductase and PPARalpha are involved in clofibrate-induced apoptosis in human keratinocytes. Apoptosis 11: 265-275.
20. Tomiyama N, Yasuda N, Iwano C, Matzno S, Matsuyama K, (2007) Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts. Clin Exp Pharmacol Physiol 34: 876-880.
21. Kim SH, Yoo CI, Kim HT, Park JY, Kwon CH, et al. (2006) Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells. Toxicol Appl Pharmacol 215: 198-207.
22. Botton T, Puissant A, Bahadoran P, Annicotte JS, Fajas L, et al. (2009) In vitro and in vivo anti-melanoma effects of ciglitazone. J Invest Dermatol 129: 1208-1218.
23. Matsuyama M, Yoshimura R, (2009) A novel approach to anticancer therapies: peroxisome proliferator activator-receptor-gamma as a new target therapy in the treatment of human urological cancer. Endocr Metab Immune Disord Drug Targets 9: 76-83.
24. Atarod EB, Kehrer JP, (2004) Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines. Free Radic Biol Med 37: 36-47.
25. Canuto RA, Muzio G, Maggiora M, Trombetta A, Martinasso G, et al. (2003) Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase. J Lipid Res 44: 56-64.
26. Penna F, Reffo P, Muzio G, Canuto RA, Baccino FM, et al. (2009) Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells. Biochem Pharmacol 77: 169-176.
27. Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C, (1993) A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197: 40-45.
28. Harvengt C, Desager JP, (1977) Plasma clofibric acid (CPIB) levels induced by three marketed compounds releasing clofibric acid, in volunteers. Int J Clin Pharmacol Biopharm 15: 1-4.
29. Fischer H, Koenig U, Eckhart L, Tschachler E, (2002) Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun 293: 722-726.
30. Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S, (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 277: 29803-29809.
31. Cheung HH, Lynn Kelly N, Liston P, Korneluk RG, (2006) Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs. Exp Cell Res 312: 2347-2357.
32. Szegezdi E, Logue SE, Gorman AM, Samali A, (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885.
33. Wang KK, (2000) Calpain and caspase: can you tell the difference? by kevin K.W. WangVol. 23, 20-26. Trends Neurosci 23: 59.
34. Martin SJ, O'Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, et al. (1995) Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 270: 6425-6428.
35. Shackleton GL, Gibson GG, Sharma RK, Howes D, Orrenius S, et al. (1995) Diverse mechanisms of calcium mobilization by peroxisome proliferators in rat hepatocytes. Toxicol Appl Pharmacol 130: 294-303.
36. Elrod HA, Sun SY, (2008) PPARgamma and Apoptosis in Cancer. PPAR Res 2008: 704165.
37. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, et al. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103.
38. Eizirik DL, Cardozo AK, Cnop M, (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29: 42-61.
39. Troy CM, Ribe EM, (2008) Caspase-2: vestigial remnant or master regulator? Sci Signal 1: pe42.
40. de Figueiredo P, Brown WJ, (1999) Clofibrate inhibits membrane trafficking to the Golgi complex and induces its retrograde movement to the endoplasmic reticulum. Cell Biol Toxicol 15: 311-323.
41. Nakamura M, Kuroiwa N, Kono Y, Takatsuki A, (2001) Characterization of clofibrate-induced retrograde Golgi membrane movement to the endoplasmic reticulum: clofibrate distinguishes the Golgi from the trans Golgi network. Biosci Biotechnol Biochem 65: 1812-1823.
42. Nakagawa T, Yuan J, (2000) Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150: 887-894.
43. Varghese J, Radhika G, Sarin A, (2001) The role of calpain in caspase activation during etoposide induced apoptosis in T cells. Eur J Immunol 31: 2035-2041.
44. Del Bello B, Moretti D, Gamberucci A, Maellaro E, (2007) Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status. Oncogene 26: 2717-2726.
45. Kim KA, Lee YA, Shin MH, (2007) Calpain-dependent calpastatin cleavage regulates caspase-3 activation during apoptosis of Jurkat T cells induced by Entamoeba histolytica. Int J Parasitol 37: 1209-1219.
46. Fanelli C, Coppola S, Barone R, Colussi C, Gualandi G, et al. (1999) Magnetic fields increase cell survival by inhibiting apoptosis via modulation of Ca2+ influx. FASEB J 13: 95-102.
47. Oh-hora M, Rao A, (2008) Calcium signaling in lymphocytes. Curr Opin Immunol 20: 250-258.
48. Dorio A, Cerella C, De Nicola M, D'Alessio M, Gualandi G, et al. (2007) Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress. Ann N Y Acad Sci 1099: 512-515.
49. Hayden RE, Pratt G, Davies NJ, Khanim FL, Birtwistle J, et al. (2009) Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. Leukemia 23: 292-304.
50. Fenton SL, Luong QT, Sarafeim A, Mustard KJ, Pound J, et al. (2003) Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease. Leukemia 17: 568-575.
51. Nilsson A, Farrants AK, Nesland JM, Finstad HS, Pedersen JI, (1995) Potentiating effects of clofibric acid on the differentiation of HL-60 human promyelocytic leukemia cells induced by retinoids. Eur J Cell Biol 67: 379-385.
52. Fenton SL, Drayson MT, Hewison M, Vickers E, Brown G, et al. (1999) Clofibric acid: a potential therapeutic agent in AML and MDS. Br J Haematol 105: 448-451.
53. Scatena R, Nocca G, Sole PD, Rumi C, Puggioni P, et al. (1999) Bezafibrate as differentiating factor of human myeloid leukemia cells. Cell Death Differ 6: 781-787.
54. Khanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, et al. (2009) Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PLoS One 4: e8147.
55. Murray JA, Khanim FL, Hayden RE, Craddock CF, Holyoake TL, et al. (2010) Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML). Br J Haematol 149: 65-69.