Apoptosis induced by clofibrate in yoshida AH-130 hepatoma cells: Role of HMG-CoA reductase

Journal of Lipid Research

Volumn 44, Issue 1, 2003, Pages 56-64

  Canuto, Rosa A ^a   Muzio, Giuliana ^a   Maggiora, Marina ^a   Trombetta, Antonella ^a   Martinasso, Germana ^a   Autelli, Riccardo ^a   Costelli, Paola ^a   Bonelli, Gabriella ^a   Baccino, Francesco M ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cholesterol; Hydroxy methyl glutaryl coenzyme A reductase; Mevalonate; Peroxisome proliferator activated receptors

Indexed keywords

CARCINOGEN; CHOLESTEROL; CHOLESTEROL ESTER; CLOFIBRATE; CYTOCHROME C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENOID; MESSENGER RNA; MEVALONIC ACID; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SIMVASTATIN;

APOPTOSIS; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID COMPOSITION; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; RECEPTOR DOWN REGULATION;

ANIMALS; APOPTOSIS; CHOLESTEROL; CLOFIBRATE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MITOCHONDRIA; RATS; RATS, LONG-EVANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0037238145     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200072-JLR200     Document Type: Article

References (41)

1. Reddy, J. K. and M. S. Rao. 1986. Peroxisome proliferators and cancer: mechanisms and implications. Trends in Pharmacol. Sci. 7: 438-443.
2. Rao, M. S., and J. K. Reddy. 1991. An overview of peroxisome-induced hepatocarcinogenesis. Environ. Health Perspect. 93: 205-209.
3. Hasmall, S. C., N. H. James, A. R. Soames, and R. A. Roberts. 1998. The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea-pig liver in vivo nor in human hepatocytes in vitro. Arch. Toxicol. 72: 777-783.
4. Bursh, W., B. Lauer, I. Timmerman-Trosiener, G. Barthel, J. Schuppler, and R. Schulte-Hermann. 1984. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis. 5: 453-458.
5. Ohmura, T, G. M. Ledda-Columbano, R. Piga, A. Columbano, J. Glemba, S. L. Katyal, J. Locker, and H. Shinozuka. 1996. Hepatocyte proliferation induced by a single dose of a peroxisome proliferator. Am. J. Pathol. 148: 815-824.
6. Hasmall, S. C., N. H. James, N. Macdonald, F. J. Gonzalez, J. M. Peters, and R. A. Roberts. 2000. Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha. Mutat. Res. 448: 193-200.
7. Chevalier, S., and R. A. Roberts. 1999. G1-arrested FaO cells reenter the cell cycle upon stimulation with the rodent non-genotoxic hepatocarcinogen nafenopin. Carcinogenesis. 20: 1209-1213.
8. Goll, V., E. Alexandre, C. Viollon-Abadie, L. Nicod, D. Jaeck, and L. Richert. 1999. Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures. Toxicol. Appl. Pharmacol. 160: 21-32.
9. Hasmall, S. C., N. H. James, A. R. Soames, R. A. Roberts. 1998. The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea-pig liver in vivo nor in human hepatocytes in vitro. Arch. Toxicol. 72: 777-783.
10. Braissant, O., F. Foufelle, C. Scotto, M. Dauca, and W. Wahli. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPARα, β, and γ in the adult rat. Endocrinology. 137: 354-366.
11. Cherkaoui, M. M., Y. C. Lone, M. Corral-Debrinski, and N. Latruffe. 1990. Differential proto-oncogene mRNA induction from rats treated with peroxisome proliferators. Biochem. Biophys. Res. Commun. 173: 855-861.
12. Bardot, O., M. C. Clemencet, M. C. Malki, and N. Latruffe. 1995. Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression. Biochem. Pharmacol. 50: 1001-1006.
13. Hiura, T. S., M. P. Kaszubowski, N. Li, and A. E. Nel. 1999. Chemical in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J. Immunol. 163: 5582-5591.
14. James, N. H., J. H. Gill, R. Brindle, N. J. Woodyatt, N. Macdonald, M. Rolfe, S. C. Hasmall, J. D. Tugwood, P. R. Holden, and R. A. Roberts. 1998. Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis. Toxicol. Lett. 12: 79-85.
15. Woodyatt, N. J., K. G. Lambe, K. A Myers, J. D. Tugwood, R. A. Roberts. 1999. The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs. Carcinogenesis. 20: 369-372.
16. Hertz, R., J. Arnon, A. Hoter, D. Shouval, and J. Bar-Theine. 1987. Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLO/PR/5 and SC-HEP-1. Cancer Lett. 34: 263-272.
17. Scuttle, R. C., J. Dislike, C. Elcombe, P. Fenner-Crisp, B. G. Lake, D. S. Mars, T. A. Pastoor, J. A Popp, D. E. Robinson, B. Schwetz, J. Tugwood, W. Wahli. 1998. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regul. Toxicol. Pharmacol. 27: 47-60.
18. Canuto, R. A., G. Muzio, M. Maggiora, R. Autelli, G. Barbiero, P. Costelli, G. Bonelli, and F. M. Baccino. 1997. Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro. Cell Death Differ. 4: 224-232.
19. Canuto, R. A., G. Muzio, G. Bonelli, M. Maggiora, R. Autelli, G. Barbiero, P. Costelli, O. Brossa, and F. M. Baccino. 1998. Peroxisome proliferators induce apoptosis in hepatoma cells. Cancer Detect. Prev. 22: 357-366.
20. Shabalina, I. G., T. Panaretakis, A. Bergstrand, and J. W. DePierre. 1999. Effects of the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid, on apoptosis in human HepG2 cells. Carcinogenesis. 20: 2237-2246.
21. Elstner, E., C. Muller, K. Koshizuka, E. A. Willimason, D. Park, H. Asou, P. Shintaku, J. W. Said, D. Heber, and H. P. Koeffler. 1998. Ligands for peroxisome proliferator-activated receptor gamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. USA. 95: 8806-8811.
22. Tsubouchi, Y., H. Sano, Y. Kawahito, S. Mukai, R. Yamada, M. Kohno, K. Inoue, T. Hla, and M. Kondo. 2000. Inhibition of human lung cancer cell growth by, the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem. Biophys. Res. Commun. 13: 400-405.
23. Berndt, J., R. Gaumert, and J. Still. 1978. Mode of action of the lipid-lowering agents, clofibrate and BM 15075, on cholesterol biosynthesis in rat liver. Atherosclerosis. 30: 147-152.
24. Rowinsky, E. K., J. J. Windle, and D. D. Von Hoff. 1999. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J. Clin. Oncol. 17: 3631-3652.
25. Abu-Qare, A. W., and M. B. Abou-Donia. 2001. Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J. Toxicol. Environ. Health B Crit. Rev. 4: 313-332.
26. Gill, J. H., P. Brickell, C. Dive, and R. A. Roberts. 1998. The rodent non-genotoxic hepatocarcinogen nafenopin suppresses apoptosis preferentially in non-cycling hepatocytes but also elevates CDK4, a cell cycle progression factor. Carcinogenesis. 19: 1743-1747.
27. Feo, E, R. A. Canuto, R. Garcea, and L. Gabriel. 1975. Effect of cholesterol content on some physical and functional properties of mitochondria isolated from adult rat liver, fetal liver, cholesterol-enriched liver and hepatomas AH-130, 3924A and 5123. Biochim. Biophys. Acta. 413: 116-134.
28. Canuto, R. A., M. E. Biocca, G. Muzio, and M. U. Dianzani. 1989. Fatty acid composition of phosholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver. Cell Biochem. Funct. 7: 11-19.
29. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
30. Pascale, R. M., M. M. Simile, M. R. De Miglio, A. Nufris, M. A. Seddaiu, M. R. Muroni, O. Danni, K. N. Rao, and F. Feo. 1995. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneoplastic liver nodules. Carcinogenesis. 16: 1537-1542.
31. Shapiro, D. J., and V. W. Rodwell. 1971. Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis. J. Biol. Chem. 246: 3210-3216.
32. Slater, T. F., and B. C. Sawyer. 1971. The stimulatoty effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. I. General features of the systems used. Biochem. J. 123: 805-814.
33. Barbiero, G., F. Duranti, G. Bonelli, J. S. Amenta, and F. M. Baccino. 1995. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp. Cell Res. 217: 410-418.
34. Canuto, R. A., M. Ferro, R. A. Salvo., A. M. Bassi, A. Trombetta, M. Maggiora, G. Martinasso, R. Lindahl, and G. Muzio. 2001. Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Biochem. J. 357: 811-818.
35. Folch, J., M. Lees, and G. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
36. Bowman, R. E., and R. C. Wolf. 1962. Rapid and specific ultramicromethod for total serum cholesterol. Clin. Chem. 8: 302-309.
37. Vameq, J., and N. Latruffe. 1999. Medical significance of peroxisome proliferator-activated receptors. Lancet. 354: 141-148.
38. Gelman, L., J. C. Fruchart, and J. Auwerx. 1999. An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer. Cell. Mol. Life Sci. 55: 932-943.
39. Bassa, B. V., D. R. Daeyoung, N. D. Vaziri, M. A. Kirschenbaum, and V. S. Kamanna. 1999. Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. Biochim. Biophys. Acta. 1449: 137-149.
40. Li, X., L. Liu, J. C. Tupper, D. D. Bannerman, R. K. Winn, S. M. Sebti, A. D. Hamilton, and J. M. Harlan. 2002. Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells. J. Biol. Chem. 277: 15309-15316.
41. Choi, J. W., and S. E. Jung. 1999. Lovastatin-induced proliferation inhibition and apoposis in C6 glial cells. J. Pharmacol. Exp. Ther. 289: 572-579.