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Volumn 113, Issue 11, 2012, Pages 3528-3535

Arsenic trioxide induces G2/M arrest in hepatocellular carcinoma cells by increasing the tumor suppressor PTEN expression

Author keywords

AKT; ARSENIC TRIOXIDE; cdc2; G2 M ARREST; PTEN

Indexed keywords

ARSENIC TRIOXIDE; CYCLIN DEPENDENT KINASE 1; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SERINE; SMALL INTERFERING RNA; THREONINE; TYROSINE; UNCLASSIFIED DRUG; WEE1 PROTEIN;

EID: 84866502736     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24230     Document Type: Article
Times cited : (47)

References (43)
  • 1
    • 78650420222 scopus 로고    scopus 로고
    • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
    • Arafa el SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA,. 2011. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat Res 706: 28-35.
    • (2011) Mutat Res , vol.706 , pp. 28-35
    • Arafa El, S.A.1    Zhu, Q.2    Shah, Z.I.3    Wani, G.4    Barakat, B.M.5    Racoma, I.6    El-Mahdy, M.A.7    Wani, A.A.8
  • 3
    • 34547591628 scopus 로고    scopus 로고
    • Arsenic compounds in the treatment of multiple myeloma: A new role for a historical remedy
    • Berenson JR, Yeh HS,. 2006. Arsenic compounds in the treatment of multiple myeloma: a new role for a historical remedy. Clin Lymphoma Myeloma 7: 192-198.
    • (2006) Clin Lymphoma Myeloma , vol.7 , pp. 192-198
    • Berenson, J.R.1    Yeh, H.S.2
  • 5
    • 33645983347 scopus 로고    scopus 로고
    • Inhibitory effect of isoflavones on prostate cancer cells and PTEN gene
    • Cao F, Jin TY, Zhou YF,. 2006. Inhibitory effect of isoflavones on prostate cancer cells and PTEN gene. Biomed Environ Sci 19: 35-41.
    • (2006) Biomed Environ Sci , vol.19 , pp. 35-41
    • Cao, F.1    Jin, T.Y.2    Zhou, Y.F.3
  • 7
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ,. 2009. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150.
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 9
    • 0037047267 scopus 로고    scopus 로고
    • Thr-161 phosphorylation of monomeric cdc2. Regulation by protein phosphatase 2C in Xenopus oocytes
    • De Smedt V, Poulhe R, Cayla X, Dessauge F, Karaiskou A, Jessus C, Ozon R,. 2002. Thr-161 phosphorylation of monomeric cdc2. Regulation by protein phosphatase 2C in Xenopus oocytes. J Biol Chem 277: 28592-28600.
    • (2002) J Biol Chem , vol.277 , pp. 28592-28600
    • De Smedt, V.1    Poulhe, R.2    Cayla, X.3    Dessauge, F.4    Karaiskou, A.5    Jessus, C.6    Ozon, R.7
  • 10
    • 0028950016 scopus 로고
    • Effects of phosphorylation by CAK on cyclin binding by cdc2 and cdk2
    • Desai D, Wessling HC, Fisher RP, Morgan DO,. 1995. Effects of phosphorylation by CAK on cyclin binding by cdc2 and cdk2. Mol Cell Biol 15: 345-350.
    • (1995) Mol Cell Biol , vol.15 , pp. 345-350
    • Desai, D.1    Wessling, H.C.2    Fisher, R.P.3    Morgan, D.O.4
  • 11
    • 34548434715 scopus 로고    scopus 로고
    • Arsenical-based cancer drugs
    • Dilda PJ, Hogg PJ,. 2007. Arsenical-based cancer drugs. Cancer Treat Rev 33: 542-564.
    • (2007) Cancer Treat Rev , vol.33 , pp. 542-564
    • Dilda, P.J.1    Hogg, P.J.2
  • 12
    • 28844435344 scopus 로고    scopus 로고
    • Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: A population-based study
    • El-Serag HB, Siegel AB, Davila JA, Shaib YH, Cayton-Woody M, McBride R, McGlynn KA,. 2006. Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: A population-based study. J Hepatol 44: 158-166.
    • (2006) J Hepatol , vol.44 , pp. 158-166
    • El-Serag, H.B.1    Siegel, A.B.2    Davila, J.A.3    Shaib, Y.H.4    Cayton-Woody, M.5    McBride, R.6    McGlynn, K.A.7
  • 13
    • 67651025106 scopus 로고    scopus 로고
    • Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization
    • Fei M, Lu M, Wang Y, Zhao Y, He S, Gao S, Ke Q, Liu Y, Li P, Cui X, Shen A, Cheng C,. 2009. Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization. Med Oncol 26: 178-185.
    • (2009) Med Oncol , vol.26 , pp. 178-185
    • Fei, M.1    Lu, M.2    Wang, Y.3    Zhao, Y.4    He, S.5    Gao, S.6    Ke, Q.7    Liu, Y.8    Li, P.9    Cui, X.10    Shen, A.11    Cheng, C.12
  • 14
    • 0025936510 scopus 로고
    • Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
    • Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW,. 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67: 197-211.
    • (1991) Cell , vol.67 , pp. 197-211
    • Gautier, J.1    Solomon, M.J.2    Booher, R.N.3    Bazan, J.F.4    Kirschner, M.W.5
  • 15
    • 45149124114 scopus 로고    scopus 로고
    • Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels
    • Han YH, Kim SH, Kim SZ, Park WH,. 2008a. Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels. J Cell Biochem 104: 862-878.
    • (2008) J Cell Biochem , vol.104 , pp. 862-878
    • Han, Y.H.1    Kim, S.H.2    Kim, S.Z.3    Park, W.H.4
  • 16
    • 50949100342 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH
    • Han YH, Kim SZ, Kim SH, Park WH,. 2008b. Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH. Cancer Lett 270: 40-55.
    • (2008) Cancer Lett , vol.270 , pp. 40-55
    • Han, Y.H.1    Kim, S.Z.2    Kim, S.H.3    Park, W.H.4
  • 17
    • 18744381273 scopus 로고    scopus 로고
    • Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene
    • Hang Y, Zheng YC, Cao Y, Li QS, Sui YJ,. 2005. Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. World J Gastroenterol 11: 2224-2229.
    • (2005) World J Gastroenterol , vol.11 , pp. 2224-2229
    • Hang, Y.1    Zheng, Y.C.2    Cao, Y.3    Li, Q.S.4    Sui, Y.J.5
  • 18
    • 79955039905 scopus 로고    scopus 로고
    • The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl) quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells
    • Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC,. 2011. The novel synthesized 2-(3-(methylamino)phenyl) -6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells. Int J Oncol 38: 1357-1364.
    • (2011) Int J Oncol , vol.38 , pp. 1357-1364
    • Huang, S.M.1    Yang, J.S.2    Tsai, S.C.3    Chen, M.H.4    Hsu, M.H.5    Lin, H.Y.6    Chou, L.C.7    Chinag, J.H.8    Lee, K.H.9    Huang, L.J.10    Kuo, S.C.11
  • 19
    • 0036731976 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells
    • Kandasamy K, Srivastava RK,. 2002. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells. Cancer Res 62: 4929-4937.
    • (2002) Cancer Res , vol.62 , pp. 4929-4937
    • Kandasamy, K.1    Srivastava, R.K.2
  • 21
    • 20744437413 scopus 로고    scopus 로고
    • Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition
    • Katayama K, Fujita N, Tsuruo T,. 2005. Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol 25: 5725-5737.
    • (2005) Mol Cell Biol , vol.25 , pp. 5725-5737
    • Katayama, K.1    Fujita, N.2    Tsuruo, T.3
  • 22
    • 69749128655 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation
    • Li Y, Qu X, Qu J, Zhang Y, Liu J, Teng Y, Hu X, Hou K, Liu Y,. 2009. Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation. Cancer Lett 284: 208-215.
    • (2009) Cancer Lett , vol.284 , pp. 208-215
    • Li, Y.1    Qu, X.2    Qu, J.3    Zhang, Y.4    Liu, J.5    Teng, Y.6    Hu, X.7    Hou, K.8    Liu, Y.9
  • 23
    • 33745936962 scopus 로고    scopus 로고
    • Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice
    • Liu B, Pan S, Dong X, Qiao H, Jiang H, Krissansen GW, Sun X,. 2006. Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice. Cancer Sci 97: 675-681.
    • (2006) Cancer Sci , vol.97 , pp. 675-681
    • Liu, B.1    Pan, S.2    Dong, X.3    Qiao, H.4    Jiang, H.5    Krissansen, G.W.6    Sun, X.7
  • 24
    • 80051704370 scopus 로고    scopus 로고
    • Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells
    • Liu ZM, Tseng JT, Hong DY, Huang HS,. 2011. Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J 438: 349-358.
    • (2011) Biochem J , vol.438 , pp. 349-358
    • Liu, Z.M.1    Tseng, J.T.2    Hong, D.Y.3    Huang, H.S.4
  • 25
    • 0035879016 scopus 로고    scopus 로고
    • Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer
    • Maeda H, Hori S, Nishitoh H, Ichijo H, Ogawa O, Kakehi Y, Kakizuka A,. 2001. Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res 61: 5432-5440.
    • (2001) Cancer Res , vol.61 , pp. 5432-5440
    • Maeda, H.1    Hori, S.2    Nishitoh, H.3    Ichijo, H.4    Ogawa, O.5    Kakehi, Y.6    Kakizuka, A.7
  • 26
    • 0027510249 scopus 로고
    • Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15
    • McGowan CH, Russell P,. 1993. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J 12: 75-85.
    • (1993) EMBO J , vol.12 , pp. 75-85
    • McGowan, C.H.1    Russell, P.2
  • 27
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • Nigg EA,. 2001. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2: 21-32.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 28
    • 0025988705 scopus 로고
    • Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates
    • Norbury C, Blow J, Nurse P,. 1991. Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J 10: 3321-3329.
    • (1991) EMBO J , vol.10 , pp. 3321-3329
    • Norbury, C.1    Blow, J.2    Nurse, P.3
  • 30
    • 0034212785 scopus 로고    scopus 로고
    • Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis
    • Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, Kim BK, Lee YY,. 2000. Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res 60: 3065-3071.
    • (2000) Cancer Res , vol.60 , pp. 3065-3071
    • Park, W.H.1    Seol, J.G.2    Kim, E.S.3    Hyun, J.M.4    Jung, C.W.5    Lee, C.C.6    Kim, B.K.7    Lee, Y.Y.8
  • 32
    • 77956234118 scopus 로고    scopus 로고
    • Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation
    • Redondo-Munoz J, Escobar-Diaz E, Hernandez Del Cerro M, Pandiella A, Terol MJ, Garcia-Marco JA, Garcia-Pardo A,. 2010. Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. Clin Cancer Res 16: 4382-4391.
    • (2010) Clin Cancer Res , vol.16 , pp. 4382-4391
    • Redondo-Munoz, J.1    Escobar-Diaz, E.2    Hernandez Del Cerro, M.3    Pandiella, A.4    Terol, M.J.5    Garcia-Marco, J.A.6    Garcia-Pardo, A.7
  • 34
    • 35348930988 scopus 로고    scopus 로고
    • EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression
    • Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg NJ, Kutala VK, Hideg K, Kuppusamy P,. 2007. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem 282: 28609-28618.
    • (2007) J Biol Chem , vol.282 , pp. 28609-28618
    • Selvendiran, K.1    Tong, L.2    Vishwanath, S.3    Bratasz, A.4    Trigg, N.J.5    Kutala, V.K.6    Hideg, K.7    Kuppusamy, P.8
  • 35
    • 73449085831 scopus 로고    scopus 로고
    • PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators
    • van Duijn PW, Ziel-van der Made AC, van der Korput JA, Trapman J,. 2010. PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators. Prostate 70: 135-146.
    • (2010) Prostate , vol.70 , pp. 135-146
    • Van Duijn, P.W.1    Ziel-Van Der Made, A.C.2    Van Der Korput, J.A.3    Trapman, J.4
  • 36
    • 63449093838 scopus 로고    scopus 로고
    • Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells
    • Wang Y, An R, Dong X, Pan S, Duan G, Sun X,. 2009. Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells. Urol Int 82: 214-221.
    • (2009) Urol Int , vol.82 , pp. 214-221
    • Wang, Y.1    An, R.2    Dong, X.3    Pan, S.4    Duan, G.5    Sun, X.6
  • 37
    • 41949111045 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia: From highly fatal to highly curable
    • Wang ZY, Chen Z,. 2008. Acute promyelocytic leukemia: From highly fatal to highly curable. Blood 111: 2505-2515.
    • (2008) Blood , vol.111 , pp. 2505-2515
    • Wang, Z.Y.1    Chen, Z.2
  • 39
    • 0032705499 scopus 로고    scopus 로고
    • The C-terminal domain of the cdc2 inhibitory kinase Myt1 interacts with cdc2 complexes and is required for inhibition of G(2)/M progression
    • Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T,. 1999. The C-terminal domain of the cdc2 inhibitory kinase Myt1 interacts with cdc2 complexes and is required for inhibition of G(2)/M progression. J Cell Sci 112 (Pt 19): 3361-3371.
    • (1999) J Cell Sci , vol.112 , Issue.PART 19 , pp. 3361-3371
    • Wells, N.J.1    Watanabe, N.2    Tokusumi, T.3    Jiang, W.4    Verdecia, M.A.5    Hunter, T.6
  • 40
    • 84862807650 scopus 로고    scopus 로고
    • The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-kappaB, MAPK, and p53 signaling
    • Weng JR, Bai LY, Chiu CF, Wang YC, Tsai MH,. 2012. The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-kappaB, MAPK, and p53 signaling. Chem Biol Interact 195: 224-230.
    • (2012) Chem Biol Interact , vol.195 , pp. 224-230
    • Weng, J.R.1    Bai, L.Y.2    Chiu, C.F.3    Wang, Y.C.4    Tsai, M.H.5
  • 41
    • 84855468446 scopus 로고    scopus 로고
    • Down-regulated miRNA-214 induces a cell cycle G1 arrest in gastric cancer cells by up-regulating the PTEN protein
    • Xiong X, Ren HZ, Li MH, Mei JH, Wen JF, Zheng CL,. 2011. Down-regulated miRNA-214 induces a cell cycle G1 arrest in gastric cancer cells by up-regulating the PTEN protein. Pathol Oncol Res 17: 931-937.
    • (2011) Pathol Oncol Res , vol.17 , pp. 931-937
    • Xiong, X.1    Ren, H.Z.2    Li, M.H.3    Mei, J.H.4    Wen, J.F.5    Zheng, C.L.6
  • 42
    • 78049462900 scopus 로고    scopus 로고
    • Radiation-inducible PTEN expression radiosensitises hepatocellular carcinoma cells
    • Zhang Y, Chen LH, Wang L, Wang HM, Zhang YW, Shi YS,. 2010. Radiation-inducible PTEN expression radiosensitises hepatocellular carcinoma cells. Int J Radiat Biol 86: 964-974.
    • (2010) Int J Radiat Biol , vol.86 , pp. 964-974
    • Zhang, Y.1    Chen, L.H.2    Wang, L.3    Wang, H.M.4    Zhang, Y.W.5    Shi, Y.S.6
  • 43
    • 77950947401 scopus 로고    scopus 로고
    • The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells
    • Zheng Y, Zhou M, Ye A, Li Q, Bai Y, Zhang Q,. 2010. The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. World J Surg Oncol 8: 31.
    • (2010) World J Surg Oncol , vol.8 , pp. 31
    • Zheng, Y.1    Zhou, M.2    Ye, A.3    Li, Q.4    Bai, Y.5    Zhang, Q.6


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