Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis

Neurobiology of Disease

Volumn 49, Issue 1, 2013, Pages 87-98

  Di Maio, Roberto ^a,b   Mastroberardino, Pier G ^a,c   Hu, Xiaoping ^a   Montero, Laura M ^a   Greenamyre, J Timothy ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b RiMED Foundation   (Italy)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

ERK signaling; Neuronal excitability; NMDA receptor subunits expression; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; IFENPRODIL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; THIOL; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; NEUROPROTECTIVE AGENT; NR2A NMDA RECEPTOR; NR2B NMDA RECEPTOR; PILOCARPINE; PIPERIDINE DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPAL SCLEROSIS; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR PATHOLOGY; NERVE CELL EXCITABILITY; NONHUMAN; OXIDATION KINETICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; EPILEPSY, TEMPORAL LOBE; METABOLISM; NERVE CELL; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; MAP KINASE SIGNALING SYSTEM; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PILOCARPINE; PIPERIDINES; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SULFHYDRYL COMPOUNDS;

EID: 84866497192     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.07.013     Document Type: Article

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