Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells

Molecular Medicine Reports

Volumn 5, Issue 4, 2012, Pages 917-922

  Chen, Xiang Qi ^a   Yang, Sheng ^a   Li, Zhi Ying ^a   Lu, Hui Shan ^a   Kang, Ming Qiang ^a   Lin, Ting Yan ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Lung cancer; Proliferation; RNA interference; Survivin

Indexed keywords

CASPASE 9; LENTIVIRUS VECTOR; SMALL INTERFERING RNA; SURVIVIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG CANCER; PLASMID; PROTEIN EXPRESSION; RNA INTERFERENCE;

APOPTOSIS; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LUNG NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84863230164     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.755     Document Type: Article

References (25)

1. Seve P and Dumontet C: Chemoresistance in non-small cell lung cancer. Curr Med Chem Anticancer Agents 5: 73-88, 2005. (Pubitemid 40081296)
2. Lee MW, Kim DS, Min NY and Kim HT: Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin. Int J Cancer 122: 2380-2384, 2008.
3. Dong AQ, Kong MJ, Ma ZY, Qian JF and Xu XH: Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. Cell Biol Int 31: 500-507, 2007.
4. Ashihara E: [RNA interference for cancer therapies]. Gan To Kagaku Ryoho 37: 2033-2041, 2010.
5. Nakashima N, Huang CL, Liu D, Ueno M and Yokomise H: Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer. Int J Oncol 37: 687-694, 2010.
6. Porebska I, Sobanska E, Kosacka M and Jankowska R: Apoptotic regulators: P53 and survivin expression in non-small cell lung cancer. Cancer Genomics Proteomics 7: 331-335, 2010.
7. Zheng W, Ma X, Wei D, Wang T, Ma Y and Yang S: Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells. DNA Seq 16: 321-328, 2005.
8. Horn ME and Waterhouse PM: Rapid match-searching for gene silencing assessment. Bioinformatics 26: 1932-1937, 2010.
9. Ichite N, Chougule M, Patel AR, Jackson T, Safe S and Singh M: Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol Cancer Ther 9: 3003-3014, 2010.
10. Biran A, Brownstein M, Haklai R and Kloog Y: Downregulation of survivin and aurora A by histone deacetylase and RAS inhi- bitors: a new drug combination for cancer therapy. Int J Cancer 128: 691-701, 2011.
11. Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3: 46-54, 2003.
12. Cappuzzo F, Hirsch FR, Rossi E, et al: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small cell lung cancer. J Natl Cancer Inst 97: 643-655, 2005. (Pubitemid 40812628)
13. Li F, Ambrosini G, Chu EY, et al: Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396: 580-584, 1998. (Pubitemid 28563719)
14. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR and Albelda SM: Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review. Clin Cancer Res 11: 3974-3986, 2005. (Pubitemid 40791561)
15. Suzuki A, Ito T, Kawano H, et al: Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 19: 1346-1353, 2000. (Pubitemid 30160627)
16. Chiou SK, Jones MK and Tarnawski AS: Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond. Med Sci Monit 9: PI25-PI29, 2003. (Pubitemid 36565381)
17. Yonesaka K, Tamura K, Kurata T, et al: Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin. Int J Cancer 118: 812-820, 2006. (Pubitemid 43157656)
18. Chao JI and Liu HF: The blockage of survivin and securin expression increases the cytochalasin B-induced cell death and growth inhibition in human cancer cells. Mol Pharmacol 69: 154-164, 2006.
19. Suzuki A, Hayashida M, Ito T, et al: Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene 19: 3225-3234, 2000. (Pubitemid 30487409)
20. Verhagen AM and Vaux DL: Cell death regulation by the mammalian IAP antagonist Diablo/Smac. Apoptosis 7: 163-166, 2002. (Pubitemid 34273131)
21. Banks DP, Plescia J, Altieri DC, et al: Survivin does not inhibit caspase-3 activity. Blood 96: 4002-4003, 2000.
22. Shi Y: Survivin structure: crystal unclear. Nat Struct Biol 7: 620-623, 2000.
23. O'Connor DS, Grossman D, Plescia J, et al: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci USA 97: 13103-13107, 2000.
24. Jang JS, Kim KM, Kang KH, et al: Polymorphisms in the survivin gene and the risk of lung cancer. Lung Cancer 60: 31-39, 2008. (Pubitemid 351434465)
25. Nabilsi NH, Broaddus RR and Loose DS: DNA methylation inhibits p53-mediated survivin repression. Oncogene 28: 2046-2050, 2009.