Lipase B from Candida antarctica binds to hydrophobic substrate-water interfaces via hydrophobic anchors surrounding the active site entrance

Journal of Molecular Catalysis B: Enzymatic

Volumn 84, Issue , 2012, Pages 48-54

  Gruber, Christian C ^a,b   Pleiss, Jürgen ^b  

^a AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Candida antarctica Lipase B (CALB); Helix 5; Interfacial activation; Molecular dynamics; Protein orientation; Substrate binding; Substrate water interface; Tributyrin

Indexed keywords

CANDIDA ANTARCTICA LIPASE B; INTERFACIAL ACTIVATION; PROTEIN ORIENTATION; SUBSTRATE BINDING; TRIBUTYRIN;

HYDROPHOBICITY; INTERFACES (MATERIALS); ISOMERS; MOLECULAR DYNAMICS; PROTEINS; VEHICULAR TUNNELS;

SUBSTRATES;

LEUCINE; LIPASE B; VALINE; WATER;

ALPHA HELIX; CANDIDA ANTARCTICA; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEIN BINDING;

CANDIDA ANTARCTICA;

EID: 84866423968     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2012.05.012     Document Type: Conference Paper

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