Concentration of free vascular endothelial growth factor and its soluble receptor, sFlt-1 in the maternal and fetal circulations of normal term pregnancies at high and low altitudes

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 10, 2012, Pages 2066-2070

  Ali, Kamal Z M ^a   Burton, Graham J ^b   Al Binali, Ali M ^a   Eskandar, Mamdoh A ^a   El Mekki, Awad A ^a   Moosa, Riyad A ^a   Abd Alla, Salah A ^a   Salih, Ali G A ^a   Sideeg, Abulqasim M B ^a   Mahfouz, Ahmed A ^a  

^a KING KHALID UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Altitude; Cord blood; Maternal blood; VEGF and sFlt 1

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ADULT; ALTITUDE; ANALYTICAL EQUIPMENT; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETUS; FETUS CIRCULATION; HUMAN; HYPOBARISM; HYPOXIA; MATERNAL BLOOD; MOTHER FETUS RELATIONSHIP; PLACENTA DEVELOPMENT; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; UMBILICAL CORD BLOOD;

ADULT; ALTITUDE; BIOLOGICAL MARKERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL BLOOD; HUMANS; INFANT, NEWBORN; POSTPARTUM PERIOD; PREGNANCY; SAUDI ARABIA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84866419913     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2012.667462     Document Type: Article

References (42)

1. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-676. (Pubitemid 36749215)
2. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992;267:10931-10934.
3. Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol 1995;11:73-91. (Pubitemid 26019602)
4. Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-674. (Pubitemid 27193480)
5. Holmes DI, Zachary I. The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 2005;6:209.
6. Wheeler T, Elcock CL, Anthony FW. Angiogenesis and the placental environment. Placenta 1995;16:289-296.
7. Ray PS, Jia J, Yao P, Majumder M, Hatzoglou M, Fox PL. A stressresponsive RNA switch regulates VEGFA expression. Nature 2009;457:915-919.
8. Khalil A, Muttukrishna S, Harrington K, Jauniaux E. Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. PLoS ONE 2008;3:e2766.
9. Troisi R, Braekke K, Harsem NK, Hyer M, Hoover RN, Staff AC. Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies. Am J Obstet Gynecol 2008;199:653.e1-653.10.
10. Tissot van Patot MC, Leadbetter G, Keyes LE, Bendrick-Peart J, Beckey VE, Christians U, Hackett P. Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness. J Appl Physiol 2005;98:1626-1629. (Pubitemid 40570769)
11. Kaufmann P, Bruns U, Leiser R, Luckhardt M, Winterhager E. The fetal vascularisation of term human placental villi. II. Intermediate and terminal villi. Anat Embryol 1985;173:203-214. (Pubitemid 16182627)
12. Kaufmann P, Luckhardt M, Schweikhart G, Cantle SJ. Cross-sectional features and three-dimensional structure of human placental villi. Placenta 1987;8:235-247. (Pubitemid 17103820)
13. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-4613. (Pubitemid 26272112)
14. Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998;111:1-6. (Pubitemid 28309201)
15. Suri C, McClain J, Thurston G, McDonald DM, Zhou H, Oldmixon EH, Sato TN, Yancopoulos GD. Increased vascularization in mice overexpressing angiopoietin-1. Science 1998;282:468-471. (Pubitemid 28483672)
16. Odorisio T, Schietroma C, Zaccaria ML, Cianfarani F, Tiveron C, Tatangelo L, Failla CM, Zambruno G. Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J Cell Sci 2002;115:2559-2567. (Pubitemid 34778073)
17. Reshetnikova OS, Burton GJ, Milovanov AP. Effects of hypobaric hypoxia on the fetoplacental unit: the morphometric diffusing capacity of the villous membrane at high altitude. Am J Obstet Gynecol 1994;171:1560-1565.
18. Mayhew TM, Charnock-Jones DS, Kaufmann P. Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies. Placenta 2004;25:127-139. (Pubitemid 38258173)
19. Kendall RL, Wang G, Thomas KA. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun 1996;226:324-328. (Pubitemid 26331903)
20. Malamitsi-Puchner A, Tziotis J, Tsonou A, Protonotariou E, Sarandakou A, Creatsas G. Changes in serum levels of vascular endothelial growth factor in males and females throughout life. J Soc Gynecol Investig 2000;7:309-312.
21. Ali KZ, Burton GJ, Khalid ME, Moosa R, Abd-Alla S. Concentrations of free vascular endothelial growth factor in the maternal and foetal circulations during pregnancy: a cross-sectional study. J Matern Fetal Neonatal Med 2010;23:1244-1248.
22. Banks RE, Forbes MA, Searles J, Pappin D, Canas B, Rahman D, Kaufmann S, et al. Evidence for the existence of a novel pregnancyassociated soluble variant of the vascular endothelial growth factor receptor, Flt-1. Mol Hum Reprod 1998;4:377-386. (Pubitemid 28228534)
23. Hornig C, Barleon B, Ahmad S, Vuorela P, Ahmed A, Weich HA. Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids. Lab Invest 2000;80:443-454. (Pubitemid 30226626)
24. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003;111:649-658. (Pubitemid 36278583)
25. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004;350:672-683. (Pubitemid 38364626)
26. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435-439. (Pubitemid 26102719)
27. Burton GJ, Jauniaux E. Sonographic, stereological and Doppler flow velocimetric assessments of placental maturity. Br J Obstet Gynaecol 1995;102:818-825.
28. Clark DE, Smith SK, He Y, Day KA, Licence DR, Corps AN, Lammoglia R, Charnock-Jones DS. A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol Reprod 1998;59:1540-1548. (Pubitemid 28549874)
29. Charnock-Jones DS, Sharkey AM, Boocock CA, Ahmed A, Plevin R, Ferrara N, Smith SK. Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells. Biol Reprod 1994;51:524-530. (Pubitemid 24297625)
30. Clark DE, Smith SK, Sharkey AM, Charnock-Jones DS. Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy. Hum Reprod 1996;11:1090-1098. (Pubitemid 26177288)
31. Drewlo S, Levytska K, Sobel M, Baczyk D, Lye SJ, Kingdom JC. Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling. J Thromb Haemost 2011;9:2486-2497.
32. Mayhew TM, Jackson MR, Boyd PA. Changes in oxygen diffusive conductances of human placentae during gestation (10-41 weeks) are commensurate with the gain in fetal weight. Placenta 1993;14:51-61. (Pubitemid 23082138)
33. Gunga HC, Kirsch K, Röcker L, Behn C, Koralewski E, Davila EH, Estrada MI, et al. Vascular endothelial growth factor in exercising humans under different environmental conditions. Eur J Appl Physiol Occup Physiol 1999;79:484-490. (Pubitemid 29201701)
34. Ali KZ. Stereological study of the effect of altitude on the trophoblast cell populations of human term placental villi. Placenta 1997;18:447-450. (Pubitemid 27326315)
35. Li H, Gu B, Zhang Y, Lewis DF, Wang Y. Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta 2005;26:210-217. (Pubitemid 40247009)
36. Tintu A, Rouwet E, Verlohren S, Brinkmann J, Ahmad S, Crispi F, van Bilsen M, et al. Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences. PLoS ONE 2009;4:e5155.
37. Soma H, Watanabe Y, Hata T. Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan. Reprod Fertil Dev 1995;7:1533-1538. (Pubitemid 26135291)
38. Burton GJ, Charnock-Jones DS, Jauniaux E. Regulation of vascular growth and function in the human placenta. Reproduction 2009;138:895-902.
39. Kingdom JC, Kaufmann P. Oxygen and placental villous development: origins of fetal hypoxia. Placenta 1997;18:613-21; discussion 623. (Pubitemid 27448416)
40. Ahmed A, Dunk C, Ahmad S, Khaliq A. Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen-a review. Placenta 2000;21 Suppl A:S16-S24.
41. Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 1993;90:10705-10709. (Pubitemid 23347111)
42. Cindrova-Davies T, Sanders DA, Burton GJ, Charnock-Jones DS. Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling. Cardiovasc Res 2011;89:671-679.