Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold

Bulletin of the Korean Chemical Society

Volumn 33, Issue 9, 2012, Pages 2991-2998

  Choi, Won Kyoung ^a,d   El Gamal, Mohammed I ^a,b,f   Choi, Hong Seok ^c   Hong, Jun Hee ^c   Baek, Daejin ^e   Choi, Kihang ^d   Oh, Chang Hyun ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Chosun University   (South Korea)

^d Korea University   (South Korea)

^e Hanseo University   (South Korea)

^f MANSOURA UNIVERSITY   (Egypt)

Author keywords

1,3,4 triarylpyrazole; A375P; Anticancer; Diarylamide; Diarylurea

Indexed keywords

1,3,4-TRIARYLPYRAZOLE; A375P; ANTICANCER; DIARYLAMIDE; DIARYLUREA;

AMIDES; CELL CULTURE; DISEASES;

SCAFFOLDS (BIOLOGY);

EID: 84866406828     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2012.33.9.2991     Document Type: Article

References (20)

1. WHO website: http://www.who.int/mediacentre/factsheets/fs297/en/.
2. Jung, M.-H.; Oh, C.-H. Bull. Korean Chem. Soc. 2008, 29, 2231.
3. Jung, M.-H.; Kim, H.; Choi, W.-K.; El-Gamal, M. I.; Park, J.-H.; Yoo, K. H.; Sim, T. B.; Lee, S. H.; Baek, D.; Hah, J.-M.; Cho, J.-H.; Oh, C.-H. Bioorg. Med. Chem. Lett. 2009, 19, 6538.
4. Nam, B. S.; Kim, H.; Oh, C.-H.; Lee, S. H.; Cho, S. J.; Sim, T. B.; Hah, J.-M.; Kim, D. J.; Choi, J. H.; Yoo, K. H. Bioorg. Med. Chem. Lett. 2009, 19, 3517.
5. Song, D.-Q.; Du, N.-N.; Wang, Y.-M.; He, W.-Y.; Jiang, E.-Z.; Cheng, S.-X.; Wang, Y.-X.; Li, Y.-H.; Wang, Y.-P.; Li, X.; Jiang, J.-D. Bioorg. Med. Chem. 2009, 17, 3873.
6. Kim, H. J.; Jung, M.-H.; Kim, H.; El-Gamal, M. I.; Sim, T. B.; Lee, S. H.; Hong, J. H.; Hah, J.-M.; Cho, J.-H.; Choi, J. H.; Yoo, K. H.; Oh, C.-H. Bioorg. Med. Chem. Lett. 2010, 20, 413.
7. Yu, H.; Jung, Y.; Kim, H.; Lee, J.; Oh, C.-H.; Yoo, K. H.; Sim, T.; Hah, J.-M. Bioorg. Med. Chem. Lett. 2010, 20, 3805.
8. Lee, J.; Kim, H.; Yu, H.; Chung, J. Y.; Oh, C.-H.; Yoo, K. H.; Sim, T.; Hah, J.-M. Bioorg. Med. Chem. Lett. 2010, 20, 1573.
9. El-Deeb, I. M.; Lee, S. H. Bioorg. Med. Chem. 2010, 18, 3860.
10. Yao, P.; Zhai, X.; Liu, D.; Qi, B. H.; Tan, H. L.; Jin, Y. C.; Gong, P. Arch. Pharm. Chem. Life Sci. 2010, 343, 17.
11. El-Gamal, M. I.; Jung, M.-H.; Lee, W. S.; Sim, T.; Yoo, K. H.; Oh, C.-H. Eur. J. Med. Chem. 2011, 46, 3218.
12. Kim, H. J.; Cho, H. J.; Kim, H.; El-Gamal, M. I.; Oh, C.-H.; Lee, S. H.; Sim, T.; Hah, J.-M.; Yoo, K. H. Bioorg. Med. Chem. Lett. 2012, 22, 3269.
13. El-Gamal, M. I.; Oh, C.-H. Bull. Korean Chem. Soc. 2012, 33, 1571.
14. Jung, M.-H.; El-Gamal, M. I.; Abdel-Maksoud, M. S.; Sim, T.; Yoo, K. H.; Oh, C.-H. Bioorg. Med. Chem. Lett. 2012, 22, 4362.
15. Wilhelm, S.; Carter, C.; Lynch, M.; Lowinger, T.; Dumas, J.; Smith, R. A.; Schwartz, B.; Simantov, R.; Kelley, S. Nat. Rev. Drug Discov. 2006, 5, 835.
16. DGNews website: http://www.pslgroup.com/news/content.nsf/medicalnews/ 852571020057CCF685257384005A45B1?Open Document&id=&count=10.
17. Capdeville, R.; Buchdunger, E.; Zimmermann, J.; Matter, A. Nat. Rev. Drug Disc. 2002, 1, 493.
18. Dean, D. K.; Takle, A. K.; Wilson, D. M. WO 2003022832 A1.
19. El-Gamal, M. I.; Oh, C.-H. Bull. Korean Chem. Soc. 2011, 32, 821.
20. NCI website: www.dtp.nci.nih.gov.