Design and synthesis of new anticancer pyrimidines with multiple-kinase inhibitory effect

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3860-3874

  El Deeb, Ibrahim Mustafa ^a,b   Lee, So Ha ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

Anticancer; Molecular modeling; Multiple kinase; Pyrimidine

Indexed keywords

1 (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 3 (4 (6 PHENYLPYRIDIN 3 YL)PYRIMIDIN 2 YL)UREA; 1 (6 (PYRIDIN 3 YL)PYRIDIN 3 YL)ETHANONE; 1 (6 PHENYLPYRIDIN 3 YL)ETHANONE; 3 (DIMETHYLAMINO) 1 (6 (PYRIDIN 3 YL)PYRIDIN 3 YL)PROP 2 EN 1 ONE; 3 (DIMETHYLAMINO) 1 (6 PHENYLPYRIDIN 3 YL)PROP 2 EN 1 ONE; 3 (DIMETHYLAMINO) 1 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 3 (TRIFLUOROMETHYL) N (4 METHYL 6 (PYRIDIN 3 YL)PYRIMIDIN 2 YL)BENZAMIDE; 3,5 BIS(TRIFLUOROMETHYL) N (4 (PYRIDIN 3 YL)PYRIMIDIN 2 YL)BENZAMIDE; 4 (6 (PYRIDIN 3 YL)PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; 4 (6 PHENYLPYRIDIN 3 YL)PYRIMIDIN 2 AMINE; 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; 4 METHYL 6 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; 4 METHYL N (2,4 DIMETHYLPHENYL) 6 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; 5 ACETYL 2 BROMOPYRIDINE; ANTINEOPLASTIC AGENT; IMATINIB; N (2,4 DIMETHYLBENZYL) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (2,4 DIMETHYLBENZYL) 4 METHYL 6 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (2,4 DIMETHYLPHENYL) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (3 (4 (PYRIDIN 3 YL)PYRIMIDIN 2 YLAMINO) 4 METHYLPHENYL)ACETAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 4 METHYL 6 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (4 METHOXYPHENYL) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N (NAPHTHALEN 2 YL) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N,N BIS(3,5 BIS(TRIFLUOROMETHYL)BENZOYL)) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N,N BIS(BENZOYL)) 4 (PYRIDIN 3 YL)PYRIMIDIN 2 AMINE; N1,N1 DIMETHYL-N4 (4 (PYRIDIN 3 YL)PYRIMIDIN 2 YL)BENZENE 1,4 DIAMINE; PROTEIN KINASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; PROTEIN DOMAIN;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PIPERAZINES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES;

EID: 77953129281     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.037     Document Type: Article

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