Synthesis and antiproliferative activitiy of novel diaryl ureas possessing a 4H-pyrido[1,2-a]pyrimidin-4-one group

Archiv der Pharmazie

Volumn 343, Issue 1, 2010, Pages 17-23

  Yao, Peng ^a   Zhai, Xin ^a   Liu, Dong ^a   Qi, Bao Hui ^a   Tan, Hai Liang ^a   Jin, Yong Cai ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

4H pyrido 1,2 a pyrimidin 4 one; Antiprofilerative activity; Synthesis

Indexed keywords

1 (2 FLUOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (2 FLUOROPHENYL) 3 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY) PHENYL)UREA; 1 (2,6 DIFLUOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (2,6 DIFLUOROPHENYL) 3 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (2,6 DIFLUOROPHENYL) 3 (4 (4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 3 YL)PHENYL)UREA; 1 (3 CHLORO 4 FLUOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (3 CHLORO 4 FLUOROPHENYL) 3 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (3 FLUOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (3 FLUOROPHENYL) 3 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (3 FLUOROPHENYL) 3 (4 (4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 3 YL)PHENYL)UREA; 1 (3,5 DICHLOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL) 3 (3 (TRIFLUOROMETHYL)PHENYL)UREA; 1 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL) 3 (3 (TRIFLUOROMETHYL)PHENYL)UREA; 1 (4 FLUOROPHENYL) 3 (4 ((4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 1 (4 FLUOROPHENYL) 3 (4 ((8 METHYL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 2 YL)METHOXY)PHENYL)UREA; 2 ((4 AMINOPHENOXY)METHYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 ((4 AMINOPHENOXY)METHYL) 8 METHYL 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 ((4 NITROPHENOXY)METHYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 (CHLOROMETHYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 2 (CHLOROMETHYL) 8 METHYL 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 (4 AMINOPHENYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 (4 NITROPHENYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 4 PYRIMIDINONE DERIVATIVE; 8 METHYL 2 ((4 NITROPHENOXY)METHYL) 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; ANTINEOPLASTIC AGENT; ETHYL 2 (4 NITROPHENYL)ACETATE; ETHYL 3 (DIMETHYLAMINO) 2 (4 NITROPHENYL)ACRYLATE; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE; DRUG DERIVATIVE; PYRIMIDINONE DERIVATIVE; UREA;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; DRUG EFFECT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 74949121528     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900130     Document Type: Article

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