High Glucose Predisposes Gene Expression and ERK Phosphorylation to Apoptosis and Impaired Glucose-Stimulated Insulin Secretion via the Cytoskeleton

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Yeo, Ronne Wee Yeh ^a,b   Yang, Kaiyuan ^c   Li, GuoDong ^d   Lim, Sai Kiang ^a,e  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Raffles Institution   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UVOMORULIN; VINCULIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL ADHESION; CELL AGGREGATION; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOTOXICITY; DEPOLYMERIZATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FOCAL ADHESION; GENE CLUSTER; GENE EXPRESSION; GENETIC TRANSCRIPTION; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STRESS FIBER;

ACTINS; ANIMALS; APOPTOSIS; CELL ADHESION; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYTOSKELETON; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84866390880     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044988     Document Type: Article

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