Critical role of c-Kit in beta cell function: Increased insulin secretion and protection against diabetes in a mouse model

Diabetologia

Volumn 55, Issue 8, 2012, Pages 2214-2225

  Feng, Z C ^a,b   Li, J ^a,b   Turco, B A ^a,b   Riopel, M ^a,b   Yee, S P ^c   Wang, R ^a,b  

^a Victoria Research Laboratories   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Beta cell function; Beta cell specific c Kit transgenic mice; C Kit W mutation; High fat diet induced diabetes; Insulin secretion

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; NEUROGENIC DIFFERENTIATION FACTOR; PROTEIN KINASE B; STEM CELL FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL ISOLATION; CELL PROLIFERATION; CELL PROTECTION; CELL SIZE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; ENZYME PHOSPHORYLATION; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GLUCOSE TOLERANCE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; ONCOGENE C KIT; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REVIEW;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, INSULIN;

EID: 84866378269     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2566-5     Document Type: Review

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