Isomannide derivatives as new class of inhibitors for human kallikrein 7

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6072-6075

  Freitas, Renato F ^a   Teixeira, Thiago S P ^a   Barros, Thalita G ^b   Santos, Jorge A N ^c   Kondo, Marcia Y ^d   Juliano, Maria A ^d   Juliano, Luiz ^d   Blaber, Michael ^e   Antunes, Octávio A C ^f   Abrahão Jr , Odonírio ^a   Pinheiro, Sergio ^b   Muri, Estela M F ^b   Puzer, Luciano ^a,g  

^a FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c INSTITUTO FEDERAL DE EDUCAÇÃO   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e FLORIDA STATE UNIVERSITY   (United States)

^f FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^g UNIVERSIDADE FEDERAL DO ABC   (Brazil)

Author keywords

Inhibitor; Kallikrein; Molecular dynamics; Pseudo peptide; Serine protease

Indexed keywords

ISOMANNIDE DERIVATIVE; KALLIKREIN INHIBITOR; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS;

BICYCLO COMPOUNDS, HETEROCYCLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KALLIKREINS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866371784     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.047     Document Type: Article

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