The adaptive immune response to colorectal cancer: From the laboratory to clinical practice

European Journal of Surgical Oncology

Volumn 38, Issue 10, 2012, Pages 889-896

  Curtis, N J ^a,b   Primrose, J N ^a,b   Thomas, G J ^a,b   Mirnezami, A H ^a,b   Ottensmeier, C H ^b  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Adaptive immune system; Colorectal cancer; Lymphocytes; Prognosis; Risk stratification

Indexed keywords

ANTINEOPLASTIC AGENT;

ADAPTIVE IMMUNITY; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER STAGING; CLINICAL PRACTICE; COLORECTAL CANCER; CONTROLLED STUDY; GOOD LABORATORY PRACTICE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; METHODOLOGY; NUCLEOTIDE SEQUENCE; OBSERVATIONAL STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT;

ADAPTIVE IMMUNITY; ANTIGENS, CD3; ANTIGENS, CD8; COHORT STUDIES; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; LYMPHOCYTE SUBSETS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS;

EID: 84866370484     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2012.05.011     Document Type: Review

References (50)

1. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 6917 2002 Dec 19 860 867
2. S. Roithmaier, A.M. Haydon, and S. Loi Incidence of malignancies in heart and/or lung transplant recipients: a single-institution experience J Heart Lung Transplant 26 8 2007 Aug 845 849
3. O.J. Finn Cancer immunology N Engl J Med 358 25 2008 Jun 19 2704 2715
4. M.L. Disis, H. Bernhard, and E.M. Jaffee Use of tumour-responsive T cells as cancer treatment Lancet 373 9664 2009 Feb 21 673 683
5. J. Galon, A. Costes, and F. Sanchez-Cabo Type, density, and location of immune cells within human colorectal tumors predict clinical outcome Science 313 5795 2006 Sep 29 1960 1964
6. J.L. Svennevig, O.C. Lunde, J. Holter, and D. Bjorgsvik Lymphoid infiltration and prognosis in colorectal carcinoma Br J Cancer 49 3 1984 Mar 375 377
7. J.R. Jass Lymphocytic infiltration and survival in rectal cancer J Clin Pathol 39 6 1986 Jun 585 589
8. F. Pages, A. Kirilovsky, and B. Mlecnik In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer J Clin Oncol 27 35 2009 Dec 10 5944 5951
9. M.J. Gooden, G.H. de Bock, N. Leffers, T. Daemen, and H.W. Nijman The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis Br J Cancer 105 1 2011 Jun 28 93 103
10. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 5 2011 Mar 4 646 674
11. M. Koch, P. Beckhove, and W.J. Op den Tumor infiltrating T lymphocytes in colorectal cancer: tumor-selective activation and cytotoxic activity in situ Ann Surg 244 6 2006 Dec 986 992
12. P. Salama, M. Phillips, and F. Grieu Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer J Clin Oncol 27 2 2009 Jan 10 186 192
13. K. Nosho, Y. Baba, and N. Tanaka Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review J Pathol 222 4 2010 Dec 350 366
14. V. Deschoolmeester, M. Baay, F. Lardon, P. Pauwels, and M. Peeters Immune cells in colorectal cancer: prognostic relevance and role of MSI Cancer Microenviron 4 3 2011 Dec 377 392
15. H. Matsushita, M.D. Vesely, and D.C. Koboldt Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting Nature 482 7385 2012 Feb 16 400 404
16. E. Ripberger, M. Linnebacher, Y. Schwitalle, J. Gebert, and D.M. von Knebel Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene J Clin Immunol 23 5 2003 Sep 415 423
17. Y. Schwitalle, M. Linnebacher, E. Ripberger, J. Gebert, and D.M. von Knebel Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells Canc Immunol 4 2004 Nov 25 14
18. Y. Garbe, C. Maletzki, and M. Linnebacher An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes PLoS One 6 11 2011 e26517
19. M. Linnebacher, A. Wienck, I. Boeck, and E. Klar Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO) J Biomed Biotechnol 2010 2010 841451
20. M. Tosolini, A. Kirilovsky, and B. Mlecnik Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer Cancer Res 71 4 2011 Feb 15 1263 1271
21. S.J. Szabo, B.M. Sullivan, S.L. Peng, and L.H. Glimcher Molecular mechanisms regulating Th1 immune responses Annu Rev Immunol 21 2003 713 758
22. H. Svensson, V. Olofsson, and S. Lundin Accumulation of CCR4CTLA-4 FOXP3CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells PLoS One 7 2 2012 e30695
23. T.J. Curiel, G. Coukos, and L. Zou Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Nat Med 10 9 2004 Sep 942 949
24. N. Hiraoka, K. Onozato, T. Kosuge, and S. Hirohashi Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions Clin Cancer Res 12 18 2006 Sep 15 5423 5434
25. J. Fu, D. Xu, and Z. Liu Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients Gastroenterology 132 7 2007 Jun 2328 2339
26. A. Chew, P. Salama, and A. Robbshaw SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer PLoS One 6 7 2011 e22047
27. J.B. Swann, and M.J. Smyth Immune surveillance of tumors J Clin Invest 117 5 2007 May 1137 1146
28. C.M. Koebel, W. Vermi, and J.B. Swann Adaptive immunity maintains occult cancer in an equilibrium state Nature 450 7171 2007 Dec 6 903 907
29. R.D. Schreiber, L.J. Old, and M.J. Smyth Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion Science 331 6024 2011 Mar 25 1565 1570
30. B. Mlecnik, M. Tosolini, and A. Kirilovsky Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction J Clin Oncol 29 6 2011 Feb 20 610 618
31. F. Pages, J. Galon, M.C. Dieu-Nosjean, E. Tartour, C. Sautes-Fridman, and W.H. Fridman Immune infiltration in human tumors: a prognostic factor that should not be ignored Oncogene 29 8 2010 Feb 25 1093 1102
32. G. Bindea, B. Mlecnik, W.H. Fridman, and J. Galon The prognostic impact of anti-cancer immune response: a novel classification of cancer patients Semin Immunopathol 33 4 2011 Jul 335 340
33. F. Pages, A. Berger, and M. Camus Effector memory T cells, early metastasis, and survival in colorectal cancer N Engl J Med 353 25 2005 Dec 22 2654 2666
34. J. Shia, J.G. Guillem, and H.G. Moore Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome Am J Surg Pathol 28 2 2004 Feb 215 223
35. K. Klintrup, J.M. Makinen, and S. Kauppila Inflammation and prognosis in colorectal cancer Eur J Cancer 41 17 2005 Nov 2645 2654
36. L. Bubendorf, A. Nocito, H. Moch, and G. Sauter Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studies J Pathol 195 1 2001 Sep 72 79
37. L. Laghi, P. Bianchi, and E. Miranda CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study Lancet Oncol 10 9 2009 Sep 877 884
38. S.C. Katz, V. Pillarisetty, and Z.M. Bamboat T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases Ann Surg Oncol 16 9 2009 Sep 2524 2530
39. D. Nagorsen, and E. Thiel Clinical and immunologic responses to active specific cancer vaccines in human colorectal cancer Clin Cancer Res 12 10 2006 May 15 3064 3069
40. N. Halama, S. Michel, and M. Kloor The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy Canc Immunol 9 2009 1
41. R.A. Lake, and R.G. van der Most A better way for a cancer cell to die N Engl J Med 354 23 2006 Jun 8 2503 2504
42. R. Ramakrishnan, D. Assudani, and S. Nagaraj Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice J Clin Invest 120 4 2010 Apr 1111 1124
43. E.A. Reits, J.W. Hodge, and C.A. Herberts Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy J Exp Med 203 5 2006 May 15 1259 1271
44. K. Yasuda, T. Nirei, E. Sunami, H. Nagawa, and J. Kitayama Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer Radiat Oncol 6 2011 49
45. A.C. Bateman, E. Jaynes, and A.R. Bateman Rectal cancer staging post neoadjuvant therapy - how should the changes be assessed? Histopathology 54 6 2009 May 713 721
46. N. Halama, S. Michel, and M. Kloor Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy Cancer Res 71 17 2011 Sep 1 5670 5677
47. G.J. Poston, J. Figueras, and F. Giuliante Urgent need for a new staging system in advanced colorectal cancer J Clin Oncol 26 29 2008 Oct 10 4828 4833
48. V. Deschoolmeester, M. Baay, and M.E. Van Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients BMC Immunol 11 2010 19
49. A. Mirnezami, R. Mirnezami, K. Chandrakumaran, K. Sasapu, P. Sagar, and P. Finan Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis Ann Surg 253 5 2011 May 890 899
50. J. Galon, F. Pages, and F.M. Marincola The immune score as a new possible approach for the classification of cancer J Transl Med 10 2012 1