Leptin as mediator of the effects of developmental programming

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 26, Issue 5, 2012, Pages 677-687

  Vickers, M H ^a   Sloboda, D M ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

developmental programming; leptin; leptin antagonist; leptin resistance; metabolic syndrome; obesity

Indexed keywords

LEPTIN;

DEVELOPMENTAL BIOLOGY; DEVELOPMENTAL PROGRAMMING; ENERGY BALANCE; ENERGY EXPENDITURE; EPIGENETICS; GENETIC REGULATION; HUMAN; HYPERLEPTINEMIA; MALNUTRITION; MATERNAL NUTRITION; METABOLIC DISORDER; NONHUMAN; OBESITY; OVERNUTRITION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CHILD DEVELOPMENT; EPIGENESIS, GENETIC; FEMALE; HUMANS; INFANT; INSULIN RESISTANCE; LEPTIN; MALNUTRITION; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; METABOLIC DISEASES; OBESITY; OVERNUTRITION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84866370171     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2012.03.005     Document Type: Review

References (89)

1. P.D. Gluckman, M.A. Hanson, and H.G. Spencer Predictive adaptive responses and human evolution Trends in Ecology and Evolution 20 2006 527 533
2. K.M. Godfrey, A. Sheppard, and P.D. Gluckman Epigenetic gene promoter methylation at birth is associated with child's later adiposity Diabetes 60 2011 1528 1534
3. C.S. Mantzoros, F. Magkos, and M. Brinkoetter Leptin in human physiology and pathophysiology American Journal of Physiology: Endocrinology and Metabolism 301 2011 E567 E584
4. D.D. Briana, and A. Malamitsi-Puchner Intrauterine growth restriction and adult disease: the role of adipocytokines European Journal of Endocrinology 160 2009 337 347
5. Y. Zhang, and P.J. Scarpace The role of leptin in leptin resistance and obesity Physiology and Behaviour 88 2006 249 256
6. M.H. Vickers Developmental programming of adult obesity: the role of leptin Current Opinion in Endocrinology, Diabetes and Obesity 14 2007 17 22
7. L. Attig, G. Solomon, and J. Ferezou Early postnatal leptin blockage leads to a long-term leptin resistance and susceptibility to diet-induced obesity in rats International Journal of Obesity (London) 32 2008 1153 1160
8. F. Savino, M.F. Fissore, and S.A. Liguori Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children? Clinical Endocrinology (Oxford) 71 2009 757 765
9. C. Pico, P. Oliver, and J. Sanchez The intake of physiological doses of leptin during lactation in rats prevents obesity in later life International Journal of Obesity (London) 31 8 2007 1199 1209
10. M.H. Vickers, P.D. Gluckman, and A.H. Coveny The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy Endocrinology 149 4 2008 1906 1913
11. S.L. Kirk, A.M. Samuelsson, and M. Argenton Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring PLoS ONE 4 2009 e5870
12. E.C. Cottrell, M.S. Martin-Gronert, and D.S. Fernandez-Twinn Leptin-independent programming of adult body weight and adiposity in mice Endocrinology 152 2011 476 482
13. W.A. Banks, A.J. Kastin, and W. Huang Leptin enters the brain by a saturable system independent of insulin Peptides 17 1996 305 311
14. R.S. Ahima, D. Prabakaran, and J.S. Flier Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function Journal of Clinical Investigation 101 5 1998 1020 1027
15. J. Udagawa, T. Hatta, and R. Hashimoto Roles of leptin in prenatal and perinatal brain development Congenital Anomalies (Kyoto) 4793) 2007 77 83
16. S.G. Bouret, and R.B. Simerly Development of leptin-sensitive circuits Journal of Neuroendocrinology 19 2007 575 582
17. S.G. Bouret, S.J. Draper, and R.B. Simerly Trophic action of leptin on hypothalamic neurons that regulate feeding Science 304 2004 108 110
18. L. Abdennebi-Najar, M. Desai, and G. Han Basal, endogenous leptin is metabolically active in newborn rat pups Journal of Maternal-Fetal and Neonatal Medicine 24 2011 1486 1491
19. T.J. Kieffer, and J.F. Habener The adipoinsular axis: effects of leptin on pancreatic beta-cells American Journal of Physiology: Endocrinology and Metabolism 278 2000 E1 E14
20. M.H. Vickers, S. Reddy, and B.A. Ikenasio Dysregulation of the adipoinsular axis - a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming Journal of Endocrinology 170 2001 323 332
21. M.G. Myers, M.A. Cowley, and H. Munzberg Mechanisms of leptin action and leptin resistance Annual Reviews in Physiology 70 2008 537 556
22. B.S. Muhlhausler, I.C. McMillen, and G. Rouzaud Appetite regulatory neuropeptides are expressed in the sheep hypothalamus before birth Journal of Neuroendocrinology 16 2004 502 507
23. K.L. Grove, and M.S. Smith Ontogeny of the hypothalamic neuropeptide Y system Physiology and Behaviour 79 2003 47 63
24. M.A. El-Haddad, M. Desai, and D. Gayle In utero development of fetal thirst and appetite: potential for programming Journal of the Society for Gynecological Investigation 11 2004 123 130
25. I. Labayen, J.R. Ruiz, and I. Huybrechts Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study Journal of Clinical Endocrinology and Metabolism 96 2011 E1330 E1334
26. M. Landt, R.L. Gingerich, and P.J. Havel Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans Clinical Chemistry 44 1998 565 570
27. M.H. Vickers, P.D. Gluckman, and A.H. Coveny Neonatal leptin treatment reverses developmental programming Endocrinology 146 2005 4211 4216
28. B.E. Levin 2006 Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis Philosophical Transactions of the Royal Society B Biological Sciences 361 2006 1107 1121
29. S. Hauguel-de Mouzon, J. Lepercq, and P. Catalano The known and unknown of leptin in pregnancy American Journal of Obstetrics AndGynecology 194 2006 1537 1545
30. G.J. Howie, D.M. Sloboda, and T. Kamal Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet Journal of Physiology 587 2009 905 915
31. R.G. Lea, D. Howe, and L.T. Hannah Placental leptin in normal, diabetic and fetal growth-retarded pregnancies Molecular Human Reproduction 6 2000 763 769
32. M.M. Vela-Huerta, E.U. San Vicente-Santoscoy, and J.M. Guizar-Mendoza Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers Journal of Pediatric Endocrinology and Metabolism 21 2008 17 22
33. A. Ornoy Prenatal origin of obesity and their complications: gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia Reproductive Toxicology 32 2011 205 212
34. M. Geary, P.J. Pringle, and M. Persaud Leptin concentrations in maternal serum and cord blood: relationship to maternal anthropometry and fetal growth British Journal of Obstetrics and Gynaecology 106 1999 1054 1060
35. S. O'Rahilly Life without leptin Nature 392 1998 330 331
36. C.J. Bautista, L. Boeck, and F. Larrea Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the rat Pediatric Research 63 2008 358 363
37. F. Delahaye, C. Breton, and P.Y. Risold Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus POMC neurons in neonatal male rat pups Endocrinology 149 2 2008 470 475
38. B. Coupe, V. Amarger, and I. Grit Nutritional programming affects hypothalamic organization and early response to leptin Endocrinology 151 2010 702 713
39. C.J. Stocker, E.T. Wargent, and M.S. Martin-Gronert Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y International Journal of Obesity (London) 2011 [epub November 2011]
40. M. Desai, D. Gayle, and G. Han Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring Reproductive Sciences 14 2007 329 337
41. L. Attig, J. Djiane, and A. Gertler Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development American Journal of Physiology: Endocrinology and Metabolism 295 2008 E1117 E1125
42. S.O. Krechowec, M. Vickers, and A. Gertler Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity Journal of Endocrinology 189 2006 355 363
43. L.J. Edwards, J.R. McFarlane, and K.G. Kauter Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 288 2005 R39 R45
44. D.S. Fernandez-Twinn, S.E. Ozanne, and S. Ekizoglou The maternal endocrine environment in the low-protein model of intra-uterine growth restriction British Journal of Nutrition 90 2003 815 822
45. J.M. Schlitt, and L.C. Schulz The source of leptin, but not leptin depletion in response to food restriction, changes during early pregnancy in mice Endocrine 2011 [epub November 2011]
46. J. Bispham, G.S. Gopalakrishnan, and J. Dandrea Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development Endocrinology 144 2003 3575 3585
47. G. Jones Early life nutrition and bone development in children Nestle Nutrition Workshop Series Pediatric Program 68 2011 227 233
48. N. Harvey, and C. Cooper The developmental origins of osteoporotic fracture Journal of the British Menopause Society 10 2004 14 15
49. M.J. Devlin, and M.L. Bouxsein Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance Bone 2011 [epub June 2011]
50. K.S. Gravenstein, J.K. Napora, and R.G. Short Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism Journal of Clinical Endocrinology and Metabolism 96 2011 E884 E890
51. S.E. Ozanne Sugaring appetite development: mechanisms of neuroendocrine programming Endocrinology 152 2011 4007 4009
52. A.M. Mistry, A. Swick, and D.R. Romsos Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice American Journal of Physiology 277 1999 R742 R747
53. M.M. Glavas, M.A. Kirigiti, and X.Q. Xiao Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet Endocrinology 151 2010 1598 1610
54. M.J. Morris, and H. Chen Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth International Journal of Obesity (London) 33 2009 115 122
55. J. Ferezou-Viala, A.F. Roy, and C. Serougne Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 293 2007 R1056 R1062
56. S.M. Steculorum, and S.G. Bouret Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring Endocrinology 152 2011 4171 4179
57. K. El-Haschimi, D.D. Pierroz, and S.M. Hileman Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity Journal of Clinical Investigation 105 2000 1827 1832
58. S.M. Hileman, D.D. Pierroz, and H. Masuzaki Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity Endocrinology 143 2002 775 783
59. B.E. Levin, A.A. Dunn-Meynell, and W.A. Banks Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 286 2004 R143 R150
60. W.A. Banks, A.B. Coon, and S.M. Robinson Triglycerides induce leptin resistance at the blood-brain barrier Diabetes 53 2004 1253 1260
61. G. Brabant, G. Muller, and R. Horn Hepatic leptin signaling in obesity FASEB Journal 19 2005 1048 1050
62. S. Henikoff, and M.A. Matzke Exploring and explaining epigenetic effects Trends in Genetics 13 1997 293 295
63. R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nature Genetics 33 Suppl. 2003 245 254
64. S. Sebert, D. Sharkey, and H. Budge The early programming of metabolic health: is epigenetic setting the missing link? American Journal of Clinical Nutrition 94 2011 1953S 1958S
65. R. Stoger In vivo methylation patterns of the leptin promoter in human and mouse Epigenetics 1 2006 155 162
66. D.W. Gong, S. Bi, and R.E. Pratley Genomic structure and promoter analysis of the human obese gene Journal of Biological Chemistry 271 1996 3971 3974
67. M.J. Holness, and M.C. Sugden Epigenetic regulation of metabolism in children born small for gestational age Current Opinion in Clinical Nutrition and Metabolism Care 9 2006 482 488
68. L. Bouchard, S. Thibault, and S.P. Guay Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy Diabetes Care 33 2010 2436 2441
69. I.C. McMillen Robinson. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming Physiology Reviews 85 2005 571 633
70. M. Marchi, S. Lisi, and M. Curcio Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter Epigenetics 6 10 2011 1198 1206
71. S.B. Heymsfield, A.S. Greenberg, and K. Fujioka Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial Journal of the American Medical Association 282 1999 1568 1575
72. A.J. Fogteloo, H. Pijl, and M. Frolich Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans Diabetes, Nutrition and Metabolism 16 2003 109 114
73. C. Schulz, K. Paulus, and O. Johren Intranasal leptin reduces appetite and induces weight loss in rats with Diet-Induced Obesity (DIO) Endocrinology 153 1 2012 143 153
74. L. Attig, T. Larcher, and A. Gertler Postnatal leptin is necessary for maturation of numerous organs in newborn rats Organogenesis 7 2011 88 94
75. S.R. Ladyman, R.A. Augustine, and D.R. Grattan Hormone interactions regulating energy balance during pregnancy Journal of Neuroendocrinology 22 2010 805 817
76. C. Stocker, J. O'Dowd, and N.M. Morton Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation International Journal of Obesity and Related Metabolic Disorders 28 2004 129 136
77. C.J. Stocker, E. Wargent, and J. O'Dowd Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 292 2007 R1810 R1818
78. K.A. Lillycrop, E.S. Phillips, and A.A. Jackson Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring Journal of Nutrition 135 2005 1382 1386
79. A. Chmurzynska, M. Stachowiak, and E. Pruszynska-Oszmalek Maternal protein and folic acid intake during gestation does not program leptin transcription or serum concentration in rat progeny Genes and Nutrition 2011 [epub July 2011]
80. A. Plagemann Perinatal nutrition and hormone-dependent programming of food intake Hormone Research 65 Suppl. 3 2006 83 89
81. M. Desai, D. Gayle, and J. Babu Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition American Journal of Physiology: regulatory, Integrative and Comparative Physiology 288 2005 R91 R96
82. M. Lopez, S. Tovar, and M.J. Vazquez Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood International Journal of Obesity (London) 31 2007 371 377
83. H. Itoh, S. Yura, and N. Sagawa Neonatal exposure to leptin reduces glucose tolerance in adult mice Acta Physiologica (Oxford) 202 2011 159 164
84. S. Yura, H. Itoh, and N. Sagawa Role of premature leptin surge in obesity resulting from intrauterine undernutrition Cell Metabolism 1 2005 371 378
85. F.P. Toste, E.G. de Moura, and P.C. Lisboa Neonatal leptin treatment programmes leptin hypothalamic resistance and intermediary metabolic parameters in adult rats British Journal of Nutrition 95 2006 830 837
86. J.L. Chan, K. Lutz, and E. Cochran Clinical effects of long-term metreleptin treatment in patients with lipodystrophy Endocrine Practice 17 6 2011 922 932
87. P. Grasso Novel approaches to the treatment of obesity and type 2 diabetes mellitus: bioactive leptin-related synthetic Peptide analogs Recent Patents on Endocrine, Metabolic and Immune Drug Discovery 5 2011 163 175
88. T.L. Horvath, and J.C. Bruning Developmental programming of the hypothalamus: a matter of fat Nature Medicine 12 2006 52 53
89. K.L. Grove, B.E. Grayson, and M.M. Glavas Development of metabolic systems Physiology and Behaviour 86 2005 646 660