Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy) ethyl]adenine (PMEA)

Chemistry and Biodiversity

Volumn 9, Issue 9, 2012, Pages 2008-2034

  Gómez Coca, Raquel B ^a,b   Blindauer, Claudia A ^a,c   Sigel, Astrid ^a   Operschall, Bert P ^a   Holý, Antonín ^d   Sigel, Helmut ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b INSTITUTO DE LA GRASA   (Spain)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonates (ANPs); Adefovir; Adenine, 9 2 (phosphonomethoxy)ethyl (PMEA); Antiviral activity; Aromatic ring stacking; Copper complexes; Isomeric equilibria; Nucleic acids; Nucleotides; Stacking interactions

Indexed keywords

1,10 PHENANTHROLINE; 2 AMINO 6 (DIMETHYLAMINO) 9 [2 (PHOSPHONOMETHOXY)ETHYL]PURINE; 2 AMINO 9 [2 (PHOSPHONOMETHOXY)ETHYL]PURINE; 2 AMINOPURINE; 2 AMINOPURINE DERIVATIVE; 2,2' BIPYRIDINE; 2,6 DIAMINO 9 [2 (PHOSPHONOMETHOXY)ETHYL]PURINE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE; ADENINE NUCLEOTIDE DERIVATIVE; ANTIVIRUS AGENT; AROMATIC AMINE; CHELATE; COPPER; HETEROAROMATIC AMINE DERIVATIVE; METAL COMPLEX; PHOSPHONIC ACID DERIVATIVE; PROTON; PURINE; PYRIMIDINE; RNA POLYMERASE; UNCLASSIFIED DRUG;

ALKALINITY; ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; PH; QUANTITATIVE ANALYSIS;

2-AMINOPURINE; ADENINE; AMINES; ANTIVIRAL AGENTS; COORDINATION COMPLEXES; COPPER; DRUG STABILITY; MOLECULAR STRUCTURE; SOLUTIONS; WATER;

EID: 84866357352     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201200022     Document Type: Article

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