New prodrugs of Adefovir and Cidofovir

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3527-3539

  Tichý, Tomáš ^a   Andrei, Graciela ^b   Dračínský, Martin ^a   Holý, Antonín ^a   Balzarini, Jan ^b   Snoeck, Robert ^b   Krečmerová, Marcela ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside phosphonate; Adefovir; Antivirals; Cidofovir; In vitro evaluation; Phosphonate ester; Prodrugs

Indexed keywords

9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE (5 METHYL 2 OXO 1,3 DIOXOLEN 4 YL)METHYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 1 (2 BROMOETHOXY) 10 (METHOXYMETHOXY)DECANE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 1 BROMO 10 (METHOXYMETHOXY)DECANE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 1 TOSYLOXY 3,6,9,12,15,18 HEXAOXAEICOSAN; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 10 BROMODECANE 1,2 DIOL; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 10 HYDROXYDECYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 11 BROMODECANE 1,2 DIOL; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 14 HYDROXY 3,6,9,12 TETRAOXAHEPTADECYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 17 [(TETRAHYDRO 2H PYRAN 2 YL)OXY] 1 TOSYLOXY 3,6,9,12,15 PENTAOXAHEPTADECAN; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 17 HYDROXY 3,6,9,12,15 PENTAOXAHEPTADECYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 2 [(10 HYDROXYDECYL)OXY]ETHYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 2 [(9,10 DIHYDROXYDECYL)OXY]ETHYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 3,6,9,12,15 PENTAOXAEICOSYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 3,6,9,12,15,18 HEXAOXAEICOSYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 4 (8 BROMOOCTYL) 2,2 DIMETHYL 1,3 DIOXOLANE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 4 [8 (2 BROMOETHOXY)OCTYL] 2,2 DIMETHYL 1,3 DIOXOLONE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE 9,10 DIHYDROXYDECYL ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS(10 HYDROXYDECYL) ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS(14 HYDROXY 3,6,9,12 TETRAOXOOCTADECYL) ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS(3,6,9,12,15,18 HEXAOXAEICOSYL) ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS(9,10 DIHYDROXYDECYL) ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS[2 [(10 HYDROXYDECYL)OXY]ETHYL] ESTER; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE BIS[2 [(9,10 DIHYDROXYDECYL)OXY]ETHYL] ESTER; ADEFOVIR; CIDOFOVIR; PRODRUG; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; VARICELLA ZOSTER VIRUS;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CYTOMEGALOVIRUS; CYTOSINE; HERPESVIRUS 3, HUMAN; HIV; HUMANS; PHOSPHONIC ACIDS; PRODRUGS; SIMPLEXVIRUS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 5; HUMAN IMMUNODEFICIENCY VIRUS; SIMPLEXVIRUS;

EID: 79957474667     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.016     Document Type: Article

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