Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes

Phytomedicine

Volumn 19, Issue 12, 2012, Pages 1125-1133

  Feng, Ru ^a   Zhou, Xuelin ^b   Or, Penelope M Y ^b   Ma, Jing Yi ^a   Tan, Xiang Shan ^a   Fu, Jie ^a   Ma, Chao ^a   Shi, Jian Gong ^a   Che, Chun Tao ^c   Wang, Yan ^a   Yeung, John H K ^b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cytochrome P450; Halenia elliptica; Molecular docking; Probe substrates; Xanthone

Indexed keywords

1 HYDROXY 2,3,5 TRIMETHOXY XANTHONE; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; DRUG METABOLISM; ENZYME INHIBITION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; HALENIA ELLIPTICA; HERB DRUG INTERACTION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LIVER MICROSOME; MEDICINAL PLANT; MOLECULAR DOCKING; MOLECULAR PROBE; PRIORITY JOURNAL;

CYTOCHROME P-450 ENZYME SYSTEM; GENTIANACEAE; HERB-DRUG INTERACTIONS; HUMANS; PHENACETIN; PLANT EXTRACTS; TESTOSTERONE; TOLBUTAMIDE; XANTHONES;

HALENIA ELLIPTICA; HEPATITIS B VIRUS;

EID: 84866351738     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.06.009     Document Type: Article

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