Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia elliptica

Phytomedicine

Volumn 16, Issue 12, 2009, Pages 1144-1150

  Wang, Yan ^a,b   Shi, Jian Gong ^b   Wang, Mu Zou ^b   Che, Chun Tao ^a   Yeung, John H K ^c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Endothelium dependent endothelium independent mechanisms; Halenia elliptica; Rat coronary artery; Tibetan herb; Vasodilation; Xanthones

Indexed keywords

1 HYDROXY 2,3,4,5 TETRAMETHOXY XANTHONE; 1 HYDROXY 2,3,4,7 TETRAMETHOXY XANTHONE; 1 HYDROXY 2,3,5 TRIMETHOXY XANTHONE; 1,5 DIHYDROXY 2,3 DIMETHOXY XANTHONE; 1,7 DIHYDROXY 2,3 DIMETHOXY XANTHONE; 1,7 DIHYDROXY 2,3,4,5 TETRAMETHOXY XANTHONE; UNCLASSIFIED DRUG; VASODILATOR AGENT; XANTHONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DRUG MECHANISM; DRUG POTENCY; HALENIA ELLIPTICA; HERB; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GENTIANACEAE; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS; VASODILATION; VASODILATOR AGENTS; XANTHONES;

HALENIA ELLIPTICA; RATTUS;

EID: 70350591117     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.03.015     Document Type: Article

References (24)

1. Cheng Y.W., and Kang J.J. Mechanisms of vasorelaxation of thoracic aorta caused by xanthone. Eur. J. Pharmacol. 336 (1997) 23-28
2. Chericoni S., Testai L., Calderone V., Flamini G., Nieri P., Morelli I., and Martinotti E. The xanthones Gentiacaulein and Gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana. Planta Med. 69 (2003) 770-772
3. Fang L.H., Mu Y.M., Lin L.L., Xiao P.G., and Du G.H. Vasorelaxant effect of euxanthone in the rat thoracic aorta. Vasc. Pharmacol. 45 (2006) 96-101
4. Gao J., Wang S.J., Fang F., Si Y.K., Yang Y.C., Liu G.T., and Shi J.G. Xanthones from Tibetan medicine Halenia elliptica and their antioxidant activity. Acta Acad. Med. Sin. 26 (2004) 364-367
5. Gao J., Wang S.J., Xu R.M., Yang Y.C., Zhang S.R., Si Y.K., and Shi J.G. Studies on chemical constituents of Halenia elliptica guided by in vivo absorption and distribution of the constituents. Acta Pharmacol. Sin. 39 (2004) 198-203
6. Ji X.Y., Tan B.K., and Zhu Y.Z. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol. Sin. 21 (2000) 1089-1094
7. Jiang D.J., Dai Z., and Li Y.J. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovas. Drug Rev. 22 (2004) 91-102
8. Lam F.F.Y., Yeung J.H.K., Chan K.M., and Or P.M.Y. Relaxant effects of Danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vasc. Pharmacol. 46 (2007) 271-277
9. Lam F.F.Y., Yeung J.H.K., Chan K.M., and Or P.M.Y. Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. Eur. J. Pharmacol. 578 (2008) 253-260
10. Lam F.FY., Yeung J.H.K., and Cheung J.H. Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 46 (2005) 361-368
11. Lam F.FY., Yeung J.H.K., Kwan Y.W., Chan K.M., and Or P.M.. Salvianolic acid B, an aqueous component of Danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Eur. J. Pharmacol. 553 (2006) 240-245
12. In: Luo D.S. (Ed). Chinese Materia Medica of Tibetan Medicine (Zhonghua Zang Bencao) (1997), Minzhu Press, Beijing 187-188
13. Matsumoto K., Akao Y., Yi H., Ohguchi K., Ito T., Tanaka T., Kobayashi E., Iinuma M., and Nozawa Y. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg. Med. Chem. 12 (2004) 5799-5806
14. Martinez G., Giuliani A., Leon O.S., Perez G., and Selles A.J.N. Effect of Mangifera indica L. extract (QF808) on protein and hepatic microsome peroxidation. Phytother. Res. 15 (2001) 581-585
15. Muruganandan S., Srinivasan K., Gupta S., Gupta P.K., and Lal J. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J. Ethnopharmac. 97 (2005) 497-501
16. Pattanaprateeb P., Ruangrungsi N., and Cordell G.A. Cytotoxic constituents from Cratoxylum arborescens. Planta Med. 71 (2005) 181-183
17. Sun H.F., Hu B.L., Fan S.F., and Ding J.Y. Three new xanthones from Halenia ellipitica D. Don. Acta Bot. Sin. 25 (1983) 460-467
18. Sun H.F., Hu B.L., Ding J.Y., and Fan S.F. Three new glycosides from Halenia elliptica. Acta Bot. Sin. 29 (1987) 422-428
19. Vieira L.M.M., and Kijjoa A. Natural occurring xanthones: recent developments. Curr. Med. Chem. 12 (2005) 2413-2446
20. Wang L.W., Kang J.J., Chen I.J., Teng C.M., and Lin C.N. Antihypertensive and vasorelaxing activities of synthetic xanthone derivatives. Bioorg. Med. Chem. 10 (2002) 567-572
21. Wang Y., Shi J.G., Wang M.Z., Che C.T., and Yeung J.H.K. Mechanisms of the vasorelaxant effect of 1-hydroxy-2,3,5-trimethoxyxanthone (HM-1) isolated from a Tibetan herb, Halenia elliptica on rat coronary artery. Life Sci. 81 (2007) 1016-1023
22. Wang Y., Shi J.G., Wang M.Z., Che C.T., and Yeung J.H.K. Mechanisms of the vasorelaxant effect of 1,5-dihydroxy-2,3-dimethoxy-xanthone, an active metabolite of 1-hydroxy-2,3,5-trimethoxyxanthone isolated from a Tibetan herb, Halenia elliptica on rat coronary artery. Life Sci. 82 (2008) 91-98
23. Wang Y., Shi J.G., Che C.T., Yeung J.H.K., and Wang M.Z. Quantitative analysis of six xanthones in Halenia elliptica by high-performance liquid chromatography-diode array detection-mass spectrometry. Chin. J. Pharm.. Anal. 28 (2008) 345-349
24. Yuan W., Zhang L.P., Cheng K.D., Zhu P., Wang Q., He H.X., and Zhu H.X. Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica. J. Nat. Prod. 69 (2006) 811-814