SiRNA Inhibits Replication of Langat Virus, a Member of the Tick-Borne Encephalitis Virus Complex in Organotypic Rat Brain Slices

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Maffioli, Carola ^a   Grandgirard, Denis ^a   Leib, Stephen L ^a,b   Engler, Olivier ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b SPIEZ LABORATORY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; VIRUS RNA;

3' UNTRANSLATED REGION; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG TARGETING; FLAVIVIRUS; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT; RNA INTERFERENCE; RNA SEQUENCE; STRUCTURAL GENE; TICK BORNE ENCEPHALITIS; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIRUS GENOME; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS VIRULENCE;

3' UNTRANSLATED REGIONS; ANIMALS; BRAIN; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; ENCEPHALITIS VIRUSES, TICK-BORNE; GENOME; HELA CELLS; HIPPOCAMPUS; HUMANS; INTERFERON-BETA; MICROSCOPY, FLUORESCENCE; RATS; RNA, SMALL INTERFERING; TRANSFECTION; VERO CELLS; VIRUS REPLICATION;

FLAVIVIRUS; IXODIDA; LANGAT VIRUS; RATTUS; RODENTIA; TICK-BORNE ENCEPHALITIS VIRUS;

EID: 84866340644     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044703     Document Type: Article

References (58)

1. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, et al. (2004) Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect 10: 1040-1055.
2. Mansfield KL, Johnson N, Phipps LP, Stephenson JR, Fooks AR, et al. (2009) Tick-borne encephalitis virus- a review of an emerging zoonosis. J Gen Virol 90: 1781-1794.
3. Holzmann H, Aberle SW, Stiasny K, Werner P, Mischak A, et al. (2009) Tick-borne encephalitis from eating goat cheese in a mountain region of Austria. Emerg Infect Dis 15: 1671-1673.
4. Moshkin MP, Novikov EA, Tkachev SE, Vlasov VV, (2009) Epidemiology of a tick-borne viral infection: theoretical insights and practical implications for public health. Bioessays 31: 620-628.
5. Chambers TJ, Diamond MS, (2003) Pathogenesis of flavivirus encephalitis. Adv Virus Res 60: 273-342.
6. Ruzek D, Dobler G, Donoso Mantke O, (2010) Tick-borne encephalitis: pathogenesis and clinical implications. Travel Med Infect Dis 8: 223-232.
7. Mandl CW, (2005) Steps of the tick-borne encephalitis virus replication cycle that affect neuropathogenesis. Virus Res 111: 161-174.
8. Hayasaka D, Nagata N, Fujii Y, Hasegawa H, Sata T, et al. (2009) Mortality following peripheral infection with tick-borne encephalitis virus results from a combination of central nervous system pathology, systemic inflammatory and stress responses. Virology 390: 139-150.
9. Haglund M, Gunther G, (2003) Tick-borne encephalitis-pathogenesis, clinical course and long-term follow-up. Vaccine 21 (Suppl 1):: S11-18.
10. Kaiser R, (1999) The clinical and epidemiological profile of tick-borne encephalitis in southern Germany 1994-98: a prospective study of 656 patients. Brain 122 (Pt 11): 2067-2078.
11. Suss J, (2011) Tick-borne encephalitis 2010: Epidemiology, risk areas, and virus strains in Europe and Asia-An overview. Ticks Tick Borne Dis 2: 2-15.
12. Suss J, (2008) Tick-borne encephalitis in Europe and beyond-the epidemiological situation as of 2007. Euro Surveill pp. 13.
13. Gritsun TS, Lashkevich VA, Gould EA, (2003) Tick-borne encephalitis. Antiviral Res 57: 129-146.
14. Kumar P, Lee SK, Shankar P, Manjunath N, (2006) A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. PLoS Med 3: e96.
15. Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, et al. (2011) Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol 85: 10154-10166.
16. Leung RK, Whittaker PA, (2005) RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 107: 222-239.
17. Stram Y, Kuzntzova L, (2006) Inhibition of viruses by RNA interference. Virus Genes 32: 299-306.
18. Tiemann K, Rossi JJ, (2009) RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med 1: 142-151.
19. Haasnoot J, Westerhout EM, Berkhout B, (2007) RNA interference against viruses: strike and counterstrike. Nat Biotechnol 25: 1435-1443.
20. DeVincenzo J, Cehelsky JE, Alvarez R, Elbashir S, Harborth J, et al. (2008) Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res 77: 225-231.
21. Davidson BL, McCray PB Jr, (2011) Current prospects for RNA interference-based therapies. Nat Rev Genet 12: 329-340.
22. Agrawal N, Dasaradhi PV, Mohmmed A, Malhotra P, Bhatnagar RK, et al. (2003) RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev 67: 657-685.
23. Hannon GJ, (2002) RNA interference. Nature 418: 244-251.
24. Mello CC, Conte D Jr, (2004) Revealing the world of RNA interference. Nature 431: 338-342.
25. Gadkari DA, (2005) RNA interference & inhibition of viruses. Indian J Med Res 121: 147-150.
26. Anthony KG, Bai F, Krishnan MN, Fikrig E, Koski RA, (2009) Effective siRNA targeting of the 3′ untranslated region of the West Nile virus genome. Antiviral Res 82: 166-168.
27. Ye C, Abraham S, Wu H, Shankar P, Manjunath N, (2011) Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis. PLoS One 6: e17889.
28. Wu X, Hong H, Yue J, Wu Y, Li X, et al. (2010) Inhibitory effect of small interfering RNA on dengue virus replication in mosquito cells. Virol J 7: 270.
29. Subramanya S, Kim SS, Abraham S, Yao J, Kumar M, et al. (2010) Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production. J Virol 84: 2490-2501.
30. Murakami M, Ota T, Nukuzuma S, Takegami T, (2005) Inhibitory effect of RNAi on Japanese encephalitis virus replication in vitro and in vivo. Microbiol Immunol 49: 1047-1056.
31. Achazi K, Patel P, Paliwal R, Radonic A, Niedrig M, et al. (2012) RNA interference inhibits replication of tick-borne encephalitis virus in vitro. Antiviral Res 93: 94-100.
32. Stoppini L, Buchs PA, Muller D, (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37: 173-182.
33. Gianinazzi C, Grandgirard D, Simon F, Imboden H, Joss P, et al. (2004) Apoptosis of hippocampal neurons in organotypic slice culture models: direct effect of bacteria revisited. J Neuropathol Exp Neurol 63: 610-617.
34. Rumyantsev AA, Murphy BR, Pletnev AG, (2006) A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice. J Virol 80: 1427-1439.
35. Price WH, Thind IS, Teasdall RD, O'Leary W, (1970) Vaccination of human volunteers against Russian spring-summer (RSS) virus complex with attenuated Langat E5 virus. Bull World Health Organ 42: 89-94.
36. Seamer J, Randles WJ, (1967) The course of Langat virus infection in mice. Br J Exp Pathol 48: 403-410.
37. Walker DH, Akov Y, Cain BG, (1979) Ultrastructural and virological aspects of Langat virus-induced SSPE in suckling hamsters. Br J Exp Pathol 60: 604-612.
38. Illavia SJ, Webb HE, (1970) An encephalitogenic virus (Langat) in mice. Isolation and persistence in cultures of brains after intraperitoneal infection with the virus. Lancet 2: 284-288.
39. Pletnev AG, (2001) Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3′ deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice. Virology 282: 288-300.
40. Sledz CA, Williams BR, (2003) RNA interference and interferon. Discov Med 3: 30-31.
41. Gantier MP, Williams BR, (2007) The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 18: 363-371.
42. Matsumoto M, Seya T, (2008) TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev 60: 805-812.
43. Holbrook MR, Aronson JF, Campbell GA, Jones S, Feldmann H, et al. (2005) An animal model for the tickborne flavivirus-Omsk hemorrhagic fever virus. J Infect Dis 191: 100-108.
44. Gelpi E, Preusser M, Garzuly F, Holzmann H, Heinz FX, et al. (2005) Visualization of Central European tick-borne encephalitis infection in fatal human cases. J Neuropathol Exp Neurol 64: 506-512.
45. Raineteau O, Rietschin L, Gradwohl G, Guillemot F, Gahwiler BH, (2004) Neurogenesis in hippocampal slice cultures. Mol Cell Neurosci 26: 241-250.
46. Cho S, Wood A, Bowlby MR, (2007) Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics. Curr Neuropharmacol 5: 19-33.
47. Kawasaki H, Tsutsui Y, (2003) Brain slice culture for analysis of developmental brain disorders with special reference to congenital cytomegalovirus infection. Congenit Anom (Kyoto) 43: 105-113.
48. Gianinazzi C, Schild M, Muller N, Leib SL, Simon F, et al. (2005) Organotypic slice cultures from rat brain tissue: a new approach for Naegleria fowleri CNS infection in vitro. Parasitology 131: 797-804.
49. Kumar S, Arankalle VA, (2010) Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis. PLoS One 5: e8615.
50. Anesti AM, Peeters PJ, Royaux I, Coffin RS, (2008) Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus. Nucleic Acids Res 36: e86.
51. Dorrbecker B, Dobler G, Spiegel M, Hufert FT, (2010) Tick-borne encephalitis virus and the immune response of the mammalian host. Travel Med Infect Dis 8: 213-222.
52. von Eije KJ, ter Brake O, Berkhout B, (2008) Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference. J Virol 82: 2895-2903.
53. Higuchi Y, Kawakami S, Hashida M, (2010) Strategies for in vivo delivery of siRNAs: recent progress. BioDrugs 24: 195-205.
54. Kim SS, Garg H, Joshi A, Manjunath N, (2009) Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol Med 15: 491-500.
55. Ma Z, Li J, He F, Wilson A, Pitt B, et al. (2005) Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun 330: 755-759.
56. Kedmi R, Ben-Arie N, Peer D, (2010) The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials 31: 6867-6875.
57. Nguyen T, Menocal EM, Harborth J, Fruehauf JH, (2008) RNAi therapeutics: an update on delivery. Curr Opin Mol Ther 10: 158-167.
58. Huesken D, Lange J, Mickanin C, Weiler J, Asselbergs F, et al. (2005) Design of a genome-wide siRNA library using an artificial neural network. Nat Biotechnol 23: 995-1001.