Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells

Metallomics

Volumn 4, Issue 7, 2012, Pages 645-652

  Qiao, Xin ^a,d   Zeitany, Alexandra E ^a   Wright, Marcus W ^a   Essader, Amal S ^b   Levine, Keith E ^b   Kucera, Gregory L ^c   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b RTI INTERNATIONAL   (United States)

^c WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^d TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDES; PLATINUM; PLATINUM COMPOUNDS;

1-FORMS; ANTI-TUMOR AGENTS; CELL VIABILITY; CELL-FREE; CIS-PLATIN; CLINICAL DRUGS; DNA ADDUCTS; DNA BINDING; DNA DAMAGES; DRUG CONCENTRATION; ELECTROSPRAY MASS SPECTROMETRY; HYBRID AGENTS; INTRACELLULAR LEVELS; LUNG CANCER CELLS; MAXIMUM FREQUENCY; MECHANISM OF ACTION; MONOFUNCTIONAL; TIME COURSE;

DNA;

ACRIDINE; ANTINEOPLASTIC AGENT; CELL DNA; CISPLATIN; GUANINE; NUCLEOTIDE; PLATINUM; UNCLASSIFIED DRUG; [PLATINUM CHLORIDE(ETHANE 1,2 DIAMINE)[N [2 (ACRIDIN 9 YLAMINO)ETHYL] N METHYLPROPIONIMIDAMIDE]]NITRATE;

ATOMIC EMISSION SPECTROMETRY; CANCER CELL; CELL FREE SYSTEM; CELL VIABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA BINDING; DNA DAMAGE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; LUNG CANCER; MASS SPECTROMETRY; PRIORITY JOURNAL; TUMOR RESISTANCE;

EID: 84863687735     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c2mt20031g     Document Type: Conference Paper

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