Enzymatic transformation of ginsenoside Rb1 by lactobacillus pentosus strain 6105 from Kimchi

Journal of Ginseng Research

Volumn 36, Issue 3, 2012, Pages 291-297

  Kim, Se Hwa ^a   Min, Jin Woo ^a   Quan, Lin Hu ^a   Lee, Sungyoung ^a   Yang, Dong Uk ^a   Yang, Deok Chun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Ginsenoside; Lactobacillus pentosus; Panax ginseng; Transformation

Indexed keywords

BACTERIA (MICROORGANISMS); LACTOBACILLUS; LACTOBACILLUS PENTOSUS; PANAX GINSENG;

EID: 84866326254     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.3.291     Document Type: Article

References (31)

1. Duo D, Jin L, Chen Y. Advances and prospects of the study on chemical constituents and pharmacological activities of Panax ginseng. J Shenyang Pharm Univ 1999;16:151-156.
2. Yuan CS, Wang CZ, Wicks SM, Qi LW. Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng. J Ginseng Res 2010;34:160-167
3. Park JH. Kim JM, Han SB, Kim NY, Surh YJ, Lee SK, Kim ND, Park MK. A new processed ginseng with fortified activity. In: Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng; 1998. Seoul: Korean Society of Ginseng, 1998. p.146-159.
4. Kim MK, Lee JW, Lee KY, Yang DC. Microbial conversion of major ginsenoside Rb1 to pharmaceutically active minor ginsenoside Rd. J Microbiol 2005;43:456-462.
5. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 2001;921:335-339.
6. Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004;133:113-120.
7. Han BH, Park MH, Han YN, Woo LK, Sankawa U, Ya-hara S, Tanaka O. Degradation of ginseng saponins under mild acidic conditions. Planta Med 1982;44:146-149.
8. Kim MH, Hong HD, Kim YC, Rhee YK, Kim KT, Rho J. Ginsenoside Changes in Red Ginseng Manufactured by Acid Impregnation Treatment. J Ginseng Res 2010;34:93-97.
9. Hasegawa H, Sung JH, Matsumiya S, Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1996;62:453-457.
10. Cheng LQ, Na JR, Kim MK, Bang MH, Yang DC. Microbial conversion of ginsenoside Rb1 to minor ginsenoside F2 and gypenoside XVII by Intrasporangium sp. GS603 isolated from soil. J Microbiol Biotechnol 2007;17:1937-1943.
11. Choi JR, Hong SW, Kim Y, Jang SE, Kim NJ, Han MJ, Kim DH. Metabolic Activities of Ginseng and Its Constituents, Ginsenoside Rb1 and Rg1, by Human Intestinal Microflora. J Ginseng Res 2011;35:301-307.
12. Atrih A, Rekhif N, Milliere JB, Lefebvre G. Detection and characterization of a bacteriocin produced by Lactobacillus plantarum C19. Can J Microbiol 1993;39:1173-1179.
13. Klaver FA, van der Meer R. The assumed assimilation of cholesterol by Lactobacilli and Bifidobacterium bifidum is due to their bile salt-deconjugating activity. Appl Environ Microbiol 1993;59:1120-1124.
14. Rhee CH, Park HD. Isolation and characterization of lactic acid bacteria producing antimutagenic substance Korean Kimchi. Korean J Appl Microbiol Biotechnol 1999;27:15-22.
15. Cheng LQ, Kim MK, Lee JW, Lee YJ, Yang DC. Conversion of major ginsenoside Rb1 to ginsenoside F2 by Caulobacter leidyia. Biotechnol Lett 2006;28:1121-1127.
16. Dong A, Ye M, Guo H, Zheng J, Guo D. Microbial transformation of ginsenoside Rb1 by Rhizopus stolonifer and Curvularia lunata. Biotechnol Lett 2003;25:339-344.
17. Dou D, Wen Y, Pei Y, Chen Y, Ma Z. Active constituents reducing side-effects of prednisone acetate in leaves of Panax ginseng C.A Meyer. Zhongguo Zhong Yao Za Zhi 1997;22:174-176, 192.
18. Sung JH, Hasegawa H, Matsumiya S, Uchiyama M. Metabolism of ginseng saponins by human intestinal bacteria. Korean J Pharmacognosy 1995;26:360-367.
19. Chi H, Ji GE. Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms. Biotechnol Lett 2005;27:765-771.
20. Chi H, Kim DH, Ji GE. Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. Biol Pharm Bull 2005;28:2102-2105.
21. Yang S, Jiang Z, Yan Q, Zhu H. Characterization of a thermostable extracellular beta-glucosidase with activities of exoglucanase and transglycosylation from Paecilomyces thermophila. J Agric Food Chem 2008;56:602-608.
22. Riou C, Salmon JM, Vallier MJ, Gunata Z, Barre P. Purification, characterization, and substrate specificity of a novel highly glucose-tolerant beta-glucosidase from Aspergillus oryzae. Appl Environ Microbiol 1998;64:3607-3614.
23. Su JH, Xu JH, Lu WY, Lin GQ. Enzymatic transformation of ginsenoside Rg3 to Rh2 using newly isolated Fusarim proliferatum ECU2042. J Mol Catal B Enzym 2006;38:113-118.
24. Saha BC, Bothast RJ. Production, purification, and characterization of a highly glucose-tolerant novel beta-glucosidase from Candida peltata. Appl Environ Microbiol 1996;62:3165-3170.
25. Kim SD, Seu JH. Enzymatic properties of the convertible enzyme of ginseng saponin produced from Rhizopus japonicas. Korean J Appl Microbiol Bioeng 1989;17:126-130.
26. Kuo LC, Lee KT. Cloning, expression, and characterization of two beta-glucosidases from isofl avone glycoside-hydrolyzing Bacillus subtilis natto. J Agric Food Chem 2008;56:119-125.
27. Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 2005;25:1069-1073.
28. 2+ channel subtypes. Mol Cells 2006;21:52-62.
29. Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci 2006;91:356-364.
30. Park EJ, Zhao YZ, Kim J, Sohn DH. A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation. Planta Med 2006;72:1250-1253.
31. Zhou W, Feng MQ, Li JY, Zhou P. Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K. J Asian Nat Prod Res 2006;8:519-527.