Carvedilol enhances mesenchymal stem cell therapy for myocardial infarction via inhibition of caspase-3 expression

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 1, 2012, Pages 62-71

  Hassan, Fatemat ^a   Meduru, Sarath ^a   Taguchi, Kazuaki ^a   Kuppusamy, M Lakshmi ^a   Mostafa, Mahmoud ^a   Kuppusamy, Periannan ^a   Khan, Mahmood ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARVEDILOL; CASPASE 3; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFECT; ENGRAFTMENT; ENZYME INHIBITION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE FIBROSIS; IN VIVO STUDY; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CARBAZOLES; CASPASE 3; CASPASE INHIBITORS; CELL SURVIVAL; CELLS, CULTURED; COMBINED MODALITY THERAPY; DOWN-REGULATION; DRUG SYNERGISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; PROPANOLAMINES; RANDOM ALLOCATION; RATS; RATS, INBRED F344; UP-REGULATION;

EID: 84866312933     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.196915     Document Type: Article

References (54)

1. Abbate A, Biondi-Zoccai GG, and Baldi A (2002) Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J Cell Physiol 193:145-153.
2. Abbate A, Morales C, De Falco M, Fedele V, Biondi Zoccai GG, Santini D, Palleiro J, Vasaturo F, Scarpa S, Liuzzo G, et al. (2007) Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion. Int J Cardiol 121:109-111. (Pubitemid 47287777)
3. Abdulla MH, Sattar MA, Abdullah NA, Khan MA, Anand Swarup KR, and Johns EJ (2011) The effect of losartan and carvedilol on vasopressor responses to adrenergic agonists and angiotensin II in the systemic circulation of Sprague Dawley rats. Auton Autacoid Pharmacol 31:13-20.
4. Arozal W, Watanabe K, Veeraveedu PT, Ma M, Thandavarayan RA, Sukumaran V, Suzuki K, Kodama M, and Aizawa Y (2010) Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats. Toxicology 274:18-26.
5. Baldi A, Abbate A, Bussani R, Patti G, Melfi R, Angelini A, Dobrina A, Rossiello R, Silvestri F, Baldi F, et al. (2002) Apoptosis and post-infarction left ventricular remodeling. J Mol Cell Cardiol 34:165-174. (Pubitemid 35222826)
6. Barone FC, Willette RN, Nelson AH, Ohlstein EH, Brooks DP, and Coatney RW (2007) Carvedilol prevents and reverses hypertrophy-induced cardiac dysfunction. Pharmacology 80:166-176. (Pubitemid 47230711)
7. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, et al. (2000) The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 19:6341-6350.
8. Cargnoni A, Ceconi C, Bernocchi P, Boraso A, Parrinello G, Curello S, and Ferrari R (2000) Reduction of oxidative stress by carvedilol: role in maintenance of ischaemic myocardium viability. Cardiovasc Res 47:556-566. (Pubitemid 30646077)
9. Carreira RS, Monteiro P, Gon Alves LM, and Providência LA (2006) Carvedilol: just another beta-blocker or a powerful cardioprotector? Cardiovasc Hematol Disord Drug Targets 6:257-266. (Pubitemid 44895104)
10. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, and Lord JM (2000) Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34-41. (Pubitemid 30211164)
11. Cutler DM, Rosen AB, and Vijan S (2006) The value of medical spending in the United States, 1960-2000. N Engl J Med 355:920-927. (Pubitemid 44315984)
12. Fazel S, Chen L, Weisel RD, Angoulvant D, Seneviratne C, Fazel A, Cheung P, Lam J, Fedak PW, Yau TM, et al. (2005) Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor. J Thorac Cardiovasc Surg 130:1310.
13. Ferrari R, Ceconi C, Curello S, Guarnieri C, Caldarera CM, Albertini A, and Visioli O (1985) Oxygen-mediated myocardial damage during ischaemia and reperfusion: role of the cellular defences against oxygen toxicity. J Mol Cell Cardiol 17:937-945. (Pubitemid 16228235)
14. Ferrari R, Guardigli G, Mele D, Percoco GF, Ceconi C, and Curello S (2004) Oxidative stress during myocardial ischaemia and heart failure. Curr Pharm Des 10:1699-1711. (Pubitemid 38559780)
15. Feuerstein G, Yue TL, Ma X, and Ruffolo RR (1998) Novel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilol. Prog Cardiovasc Dis 41:17-24. (Pubitemid 28381711)
16. Flesch M, Maack C, Cremers B, Bäumer AT, Südkamp M, and Böhm M (1999) Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. Circulation 100:346-353. (Pubitemid 29362403)
17. Foncea R, Galvez A, Perez V, Morales MP, Calixto A, Melendez J, Gonzalez-Jara F, Diaz-Araya G, Sapag-Hagar M, Sugden PH, et al. (2000) Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes. Biochem Biophys Res Commun 273:736-744. (Pubitemid 30599053)
18. Grieve DJ, Byrne JA, Cave AC, and Shah AM (2004) Role of oxidative stress in cardiac remodelling after myocardial infarction. Heart Lung Circ 13:132-138. (Pubitemid 38877983)
19. Hayashi T, De Velasco MA, Saitou Y, Nose K, Nishioka T, Ishii T, and Uemura H (2010) Carvedilol protects tubular epithelial cells from ischemia-reperfusion injury by inhibiting oxidative stress. Int J Urol 17:989-995.
20. Hill MF and Singal PK (1996) Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am J Pathol 148:291-300. (Pubitemid 26019664)
21. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
22. Jessup M and Brozena S (2003) Heart failure. N Engl J Med 348:2007-2018.
23. Khan M, Kutala VK, Vikram DS, Wisel S, Chacko SM, Kuppusamy ML, Mohan IK, Zweier JL, Kwiatkowski P, and Kuppusamy P (2007a) Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function. Am J Physiol Heart Circ Physiol 293:H2129-H2139. (Pubitemid 47605854)
24. Khan M, Mohan IK, Kutala VK, Kumbala D, and Kuppusamy P (2007b) Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemiareperfusion injury by scavenging of reactive oxygen species. J Pharmacol Exp Ther 323:813-821. (Pubitemid 350146050)
25. Khan M, Meduru S, Mohan IK, Kuppusamy ML, Wisel S, Kulkarni A, Rivera BK, Hamlin RL, and Kuppusamy P (2009) Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart. J Mol Cell Cardiol 47:275-287.
26. Khan M, Meduru S, Mostafa M, Khan S, Hideg K, and Kuppusamy P (2010) Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling. J Pharmacol Exp Ther 333:421-429.
27. Khan M, Meduru S, Gogna R, Madan E, Citro L, Kuppusamy ML, Sayyid M, Mostafa M, Hamlin RL, and Kuppusamy P (2012) Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function. Cardiovasc Res 93:89-99.
28. Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, Utsumi H, and Takeshita A (2000) Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ Res 87:392-398.
29. Kopecky SL (2006) Effect of beta blockers, particularly carvedilol, on reducing the risk of events after acute myocardial infarction. Am J Cardiol 98:1115-1119.
30. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJ, and Sabbadini RA (1996) Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest 98:2854-2865.
31. Kudo M, Wang Y, Wani MA, Xu M, Ayub A, and Ashraf M (2003) Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol 35:1113-1119. (Pubitemid 37083255)
32. Kumar A, Prakash A, and Dogra S (2011) Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats. Pharmacol Rep 63:915-923.
33. Lauer MS (2012) Advancing cardiovascular research. Chest 141:500-505.
34. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, and Mann MJ (2009) Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg 208:607-613.
35. Li Q, Turdi S, Thomas DP, Zhou T, and Ren J (2010) Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction. Toxicol Lett 195:119-126.
36. Mathers CD and Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3:e442.
37. Menasche P (2011) Cardiac cell therapy: lessons from clinical trials. J Mol Cell Cardiol 50:258-265.
38. Monteiro P, Duarte AI, Moreno A, Gonçalves LM, and Providência LA (2003) Carvedilol improves energy production during acute global myocardial ischaemia. Eur J Pharmacol 482:245-253. (Pubitemid 37508518)
39. Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E, Gambert SR, Cigola E, and Anversa P (1996) Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 28:2005-2016. (Pubitemid 26340560)
40. Packer M (1998) Beta-adrenergic blockade in chronic heart failure: principles, progress, and practice. Prog Cardiovasc Dis 41:39-52.
41. Palojoki E, Saraste A, Eriksson A, Pulkki K, Kallajoki M, Voipio-Pulkki LM, and Tikkanen I (2001) Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 280:H2726-H2731.
42. Sabbah HN (2000) Apoptotic cell death in heart failure. Cardiovasc Res 45:704-712.
43. Schwarz ER, Kersting PH, Reffelmann T, Meven DA, Al-Dashti R, Skobel EC, Klosterhalfen B, and Hanrath P (2003) Cardioprotection by Carvedilol: antiapoptosis is independent of beta-adrenoceptor blockage in the rat heart. J Cardiovasc Pharmacol Ther 8:207-215. (Pubitemid 37158967)
44. Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, and Jia ZQ (1999) Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100:II247-II256. (Pubitemid 29523543)
45. Wei H, Li Z, Hu S, Chen X, and Cong X (2010) Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. J Cell Biochem 111:967-978.
46. Widmann C, Gibson S, Jarpe MB, and Johnson GL (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180. (Pubitemid 29056951)
47. Wisel S, Khan M, Kuppusamy ML, Mohan IK, Chacko SM, Rivera BK, Sun BC, Hideg K, and Kuppusamy P (2009) Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression. J Pharmacol Exp Ther 329:543-550.
48. Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, et al. (2010a) Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem 109:1185-1191.
49. Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, and Go AS (2010b) Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med 362:2155-2165.
50. Yoshikawa E, Marui A, Tsukashita M, Nishina T, Wang J, Muranaka H, Ikeda T, and Komeda M (2010) Carvedilol may alleviate late cardiac remodelling following surgical ventricular restoration. Eur J Cardiothorac Surg 37:362-367.
51. Yue TL, Cheng HY, Lysko PG, McKenna PJ, Feuerstein R, Gu JL, Lysko KA, Davis LL, and Feuerstein G (1992) Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. J Pharmacol Exp Ther 263:92-98.
52. Zak R (1973) Cell proliferation during cardiac growth. Am J Cardiol 31:211-219.
53. Zeng H, Liu X, and Zhao H (2003) Effects of carvedilol on cardiomyocyte apoptosis and gene expression in vivo after ischemia-reperfusion in rats. J Huazhong Univ Sci Technolog Med Sci 23:127-130. (Pubitemid 41559736)
54. Zhang M, Methot D, Poppa V, Fujio Y, Walsh K, and Murry CE (2001) Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J Mol Cell Cardiol 33:907-921. (Pubitemid 32545326)