Vitamin K and the nervous system: An overview of its actions

Advances in Nutrition

Volumn 3, Issue 2, 2012, Pages 204-212

  Ferland, Guylaine ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST SPECIFIC PROTEIN 6; GROWTH ARREST-SPECIFIC PROTEIN 6; PROTEIN S; SIGNAL PEPTIDE; SPHINGOLIPID; VITAMIN K GROUP;

AGE; ANIMAL; CENTRAL NERVOUS SYSTEM; COGNITION; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MOUSE; PERIPHERAL NERVOUS SYSTEM; RABBIT; RAT; REVIEW;

AGE FACTORS; ANIMALS; CENTRAL NERVOUS SYSTEM; COGNITION; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; PERIPHERAL NERVOUS SYSTEM; PROTEIN S; RABBITS; RATS; SPHINGOLIPIDS; VITAMIN K;

EID: 84866279639     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.111.001784     Document Type: Review

References (67)

1. Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol. 1993;13:4976-85.
2. Prieto AL, Weber JL, Tracy S, Heeb MJ, Lai C. Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system. Brain Res. 1999;816:646-61.
3. Bartke N, Hannun YA. Bioactive sphingolipids:metabolism and function. J Lipid Res. 2009;50:Suppl:S91-6.
4. Lev M. Sphingolipid biosynthesis and vitamin K metabolism in Bacteroides melaninogenicus. Am J Clin Nutr. 1979;32:179-86.
5. Lev M, Sundaram S. Modulation of glycosphingolipid synthesis by vitamin K depletion in bacteria and brain. In:Suttie JW, editor. Current Advances in Vitamin K Research:Proceedings of the 17th Steenbock Symposium. Madison:University of Wisconsin-Madison; 1988.
6. Thijssen HH, Drittij-Reijnders MJ. Vitamin K distribution in rat tissues:dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr. 1994;72:415-25.
7. Huber AM, Davidson KW, O'Brien-Morse ME, Sadowski JA. Tissue phylloquinone and menaquinones in rats are affected by age and gender. J Nutr. 1999;129:1039-44.
8. Carrié I, Portoukalian J, Vicaretti R, Rochford J, Potvin S, Ferland G. Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. J Nutr. 2004;134:167-72.
9. Carrié I, Portoukalian J, Rochford J, Ferland G. Life-long low phylloquinone intake is associated with cognitive impairments in old rats. J Nutr. 2011;141:1495-501.
10. Zeidan YH, Hannun YA. Translational aspects of sphingolipid metabolism. Trends Mol Med. 2007;13:327-36.
11. Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A. 2004;101:2070-5.
12. Jana A, Hogan EL, Pahan K. Ceramide and neurodegeneration:susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci. 2009;278:5-15.
13. Posse de Chaves E, Sipione S. Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction. FEBS Lett. 2010; 584:1748-59.
14. Lev M. Apparent requirement for vitamin K of rumen strains of Fusiformis nigrescens. Nature. 1958;181:203-4.
15. Lev M. Vitamin K deficiency in Fusiformis nigrescens. I. Influence on whole cells and cell envelope characteristics. J Bacteriol. 1968;95:2317-24.
16. Lev M, Milford AF. Vitamin K stimulation of sphingolipid synthesis. Biochem Biophys Res Commun. 1971;45:358-62.
17. Lev M, Milford AF. Effect of vitamin K depletion and restoration on sphingolipid metabolism in Bacteroides melaninogenicus. J Lipid Res. 1972;13:364-70.
18. Lev M, Milford AF. The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus:induction by vitamin K. Arch Biochem Biophys. 1973;157:500-8.
19. Sundaram KS, Lev M. Warfarin administration reduces synthesis of sulfatides and other sphingolipids in mouse brain. J Lipid Res. 1988;29:1475-9.
20. Sundaram KS, Lev M. Regulation of sulfotransferase activity by vitamin K in nouse brain. Arch Biochem Biophys. 1990;277:109-13.
21. Sundaram KS, Lev M. Vitamin K and phosphate mediated enhancement of brain sulfotransferase activity. Biochem Biophys Res Commun. 1990;169:927-32.
22. Sundaram KS, Lev M. Purification and activation of brain sulfotransferase. J Biol Chem. 1992;267:24041-4.
23. Sundaram KS, Fan JH, Engelke JA, Foley AL, Suttie JW, Lev M. Vitamin K status influences brain sulfatide metabolism in young mice and rats. J Nutr. 1996;126:2746-51.
24. Crivello NA, Casseus SL, Peterson JW, Smith DE, Booth SL. Age-and brain region-specific effects of dietary vitamin K on myelin sulfatides. J Nutr Biochem. 2010;21:1083-8.
25. Varnum BC, Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW, Trail G, Clogston C, Toso RJ, et al. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature. 1995;373:623-6.
26. Tanabe K, Nagata K, Ohashi K, Nakano T, Arita H, Mizuno K. Roles of gamma-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6. FEBS Lett. 1997;408:306-10.
27. Romero EE, Velazquez-Estades LJ, Deo R, Schapiro B, Roth DA. Cloning of rat vitamin K-dependent gamma-glutamyl carboxylase and developmentally regulated gene expression in postimplantation embryos. Exp Cell Res. 1998;243:334-46.
28. de Boer-van den Berg MA, Thijssen HH, Vermeer C. The in vivo effects of acenocoumarol, phenprocoumon and warfarin on vitamin K epoxide reductase and vitamin K-dependent carboxylase in various tissues of the rat. Biochim Biophys Acta. 1986;884:150-7.
29. Li R, Chen J, Hammonds G, Phillips H, Armanini M,Wood P, Bunge R, Godowski PJ, Sliwkowski MX, Mather JP. Identification of Gas6 as a growth factor for human Schwann cells. J Neurosci. 1996;16:2012-9.
30. Tsaioun KI, Denisova NA, Obin M, Joseph J. Novel growth factor Gas6, phosphatidylserine and their age-related changes in the rat brain. Neurosci Res Commun. 2000;26:113-22.
31. Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman ME. Growth arrestspecific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signalregulated kinase (ERK) and Akt. Mol Endocrinol. 1999;13:191-201.
32. Allen MP, Linseman DA, Udo H, Xu M, Schaack JB, Varnum B, Kandel ER, Heidenreich KA,Wierman ME. Novel mechanism for gonadotropinreleasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase. Mol Cell Biol. 2002;22:599-613.
33. Funakoshi H, Yonemasu T, Nakano T, Matumoto K, Nakamura T. Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. J Neurosci Res. 2002;68:150-60.
34. Prieto AL, O'Dell S, Varnum B, Lai C. Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons. Neuroscience. 2007;150:319-34.
35. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature. 2004;430:631-9.
36. Yagami T, Ueda K, Asakura K, Sakaeda T, Nakazato H, Kuroda T, Hata S, Sakaguchi G, Itoh N, Nakano T, et al. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Neuropharmacology. 2002;43:1289-96.
37. Yagami T, Ueda K, Asakura K, Okamura N, Sakaeda T, Sakaguchi G, Itoh N, Hashimoto Y, Nakano T, Fujimoto M. Effect of Gas6 on secretory phospholipase A(2)-IIA-induced apoptosis in cortical neurons. Brain Res. 2003;985:142-9.
38. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308:1314-8.
39. Binder MD, Cate HS, Prieto AL, Kemper D, Butzkueven H, Gresle MM, Cipriani T, Jokubaitis VG, Carmeliet P, Kilpatrick TJ. Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. J Neurosci. 2008;28:5195-206.
40. Shankar SL, O'Guin K, Cammer M, McMorris FA, Stitt TN, Basch RS, Varnum B, Shafit-Zagardo B. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci. 2003;23:4208-18.
41. Shankar SL, O'Guin K, Kim M, Varnum B, Lemke G, Brosnan CF, Shafit-Zagardo B. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci. 2006;26:5638-48.
42. Matsushima GK, Morell P. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol. 2001;11:107-16.
43. Grommes C, Lee CY, Wilkinson BL, Jiang Q, Koenigsknecht-Talboo JL, Varnum B, Landreth GE. Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases. J Neuroimmune Pharmacol. 2008;3:130-40.
44. Binder MD, Xiao J, Kemper D, Ma GZ, Murray SS, Kilpatrick TJ. Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination. PLoS ONE. 2011;6:e17727.
45. Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlbäck B, Daemen MJ, Carmeliet P, Moons L. Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol. 2008;216:55-63.
46. Tsiperson V, Li X, Schwartz GJ, Raine CS, Shafit-Zagardo B. GAS6 enhances repair following cuprizone-induced demyelination. PLoS ONE. 2010;5:e15748.
47. DiScipio AW, Burchard KW. Continuous arteriovenous hemofiltration attenuates polymorphonuclear leukocyte phagocytosis in porcine intraabdominal sepsis. Am J Surg. 1997;173:174-80.
48. Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell. 1995;80:661-70.
49. He X, Shen L, Bjartell A, Dahlback B. The gene encoding vitamin Kdependent anticoagulant protein S is expressed in multiple rabbit organs as demonstrated by northern blotting, in situ hybridization, and immunohistochemistry. J Histochem Cytochem. 1995;43:85-96.
50. Phillips DJ, Greengard JS, Fernandez JA, Ribeiro M, Evatt BL, Griffin JH, Hooper WC. Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells. J Neurochem. 1993;61:344-7.
51. Liu D, Guo H, Griffin JH, Fernandez JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003;107:1791-6.
52. Zhong Z, Wang Y, Guo H, Sagare A, Fernandez JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormonebinding globulin-like region. J Neurosci. 2010;30:15521-34.
53. Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernandez JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009; 114:2307-14.
54. Tsang CK, Kamei Y. Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factormediated neurite outgrowth from PC12D cells. Neurosci Lett. 2002; 323:9-12.
55. Nakajima M, Furukawa S, Hayashi K, Yamada A, Kawashima T, Hayashi Y. Age-dependent survival-promoting activity of vitamin K on cultured CNS neurons. Brain Res Dev Brain Res. 1993;73:17-23.
56. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA. Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003;23:5816-26.
57. Li J, Wang H, Rosenberg PA. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. J Neurosci Res. 2009;87:1997-2005.
58. Sakaue M, Mori N, Okazaki M, Kadowaki E, Kaneko T, Hemmi N, Sekiguchi H, Maki T, Ozawa A, Hara S, et al. Vitamin K has the potential to protect neurons from methylmercury-induced cell death in vitro. J Neurosci Res. 2011;89:1052-8.
59. Pauli RM. Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy. Pathol Immunopathol Res. 1988;7:107-12.
60. Hall JG, Pauli RM, Wilson KM. Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med. 1980;68:122-40.
61. Presse N, Shatenstein B, Kergoat MJ, Ferland G. Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. J Am Diet Assoc. 2008;108:2095-9.
62. Sato Y, Nakamura R, SatohM, Fujishita K, Mori S, Ishida S, Yamaguchi T, Inoue K, Nagao T, Ohno Y. Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification. Circ Res. 2005; 97:550-7.
63. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. Pharmacology and management of the vitamin K antagonists:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:160S-98S.
64. Cocchetto DM, Miller DB, Miller LL, Bjornsson TD. Behavioral perturbations in the vitamin K-deficient rat. Physiol Behav. 1985;34:727-34.
65. Reddi K, Henderson B, Meghji S, Wilson M, Poole S, Hopper C, Harris M, Hodges SJ. Interleukin 6 production by lipopolysaccharidestimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Cytokine. 1995;7:287-90.
66. Moriya M, Nakatsuji Y, Okuno T, Hamasaki T, Sawada M, Sakoda S. Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol. 2005;170:11-20.
67. Ohsaki Y, Shirakawa H, Hiwatashi K, Furukawa Y, Mizutani T, Komai M. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci Biotechnol Biochem. 2006;70:926-32.