Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: Association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters

Medical Oncology

Volumn 29, Issue 2, 2012, Pages 411-417

  Naidu, R ^c   Yip, C H ^a,b   Taib, N A M ^a,b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^c MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Breast cancer; Polymorphism; TCF7L2

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2; TCF7L2 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALAYSIA; PRIORITY JOURNAL; BREAST; BREAST TUMOR; CANCER GRADING; CANCER STAGING; CASE CONTROL STUDY; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

ADULT; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROGNOSIS; RISK FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84866272543     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-9837-8     Document Type: Article

References (33)

1. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 2004;303:1483-7.
2. Prunier C, Hocevar BA, Howe PH. Wnt signaling: physiology and pathology. Growth Factors. 2004;22:141-50.
3. Sjoblom T, et al. The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314:268-74.
4. Wong NA, Pignatelli M. Beta-catenin-a linchpin in colorectal carcinogenesis? Am J Pathol. 2002;160:389-401.
5. Bafico A, Liu G, Goldin L, Harris V, Aaronson SA. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell. 2004;6:497-506.
6. Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res. 2007;9:R63.
7. Lin SY, et al. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA. 2000;97:4262-6.
8. Ozaki S. Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. Oncol Rep. 2005;14:1437-43.
9. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398:422-6.
10. Barker N, Huls G, Korinek V, Clevers H. Restricted high level expression of TCF-4 protein in intestinal and mammary gland epithelium. Am J Pathol. 1999;154:29-35.
11. Duval A, et al. The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res. 2000;60:3872-9.
12. Sun P, Xiong H, Kim TH, Ren B, Zhang Z. Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin- 1 signaling potentiates proliferation and survival of prostate cancer cells. Mol Pharmacol. 2006;69:520-31.
13. Li CY, Wang Y, Cui ZS, Wang EH. Expression of T cell factor-4 in non-small-cell lung cancer. Chin Med J (Engl). 2005;118: 136-40.
14. Grant SF. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320-3.
15. Sladek R. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445:881-5.
16. Cauchi S, et al. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. Mol Med. 2007;85:777-82.
17. Bodhini D, Radha V, Dhar M, Narayani N, Mohan V. The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metabolism. 2007;56:1174-8.
18. Burwinkel B, et al. Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study. BMC Cancer. 2006;6:268.
19. Agalliu I, et al. Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a populationbased study. Prostate. 2008;68:740-7.
20. Folsom AR, et al. Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. 2008;31:905-9.
21. Slattery ML, et al. Transcription factor 7-like 2 polymorphism and colon cancer. Cancer Epidemiol Biomarkers Prev. 2008;17: 978-82.
22. Goode EL, et al. No association between TCF7L2 variant and risk of breast or ovarian cancer. BMC Cancer. 2009;9:312-5.
23. Hazra A, Fuchs CS, Chan AT, Giovannucci EL, Hunter DJ. Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk. Cancer Causes Control. 2008;19:975-80.
24. Shtutman M, et al. The cyclin D1 gene is a target of the betacatenin/LEF-1 pathway. Proc Natl Acad Sci USA. 1999;96: 5522-7.
25. Lim GCC, Halimah Y. Second report of the national cancer registry. Cancer incidence in Malaysia 2003. Kuala Lumpur: National cancer registry; 2004.
26. Naidu R, Har YC, Taib NA. Polymorphism of FGFR4 Gly388Arg does not confer an increased risk to breast cancer development. Oncol Res. 2009;18(2-3):65-71.
27. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer I. Histopathology. 1991;19:403-10.
28. Bloom HIG, Richardson WW. Histological grading and prognosis. Br J Cancer. 1957;11:359-77.
29. Breast. AJCC cancer staging manual. In: American Joint Committee on Cancer, 6th editor. New York: Springer; 2002. p. 171- 180.
30. Singletary E, et al. Revision of the American Joint committee on cancer staging system for breast cancer. J Clin Oncol. 2002;20: 3628-36.
31. Naidu R, Har YC, Taib NA. P27 V109G Polymorphism is associated with lymph node metastases but not with increased risk of breast cancer. J Exp Clin Cancer Res. 2007;26:133-40.
32. Tsao DA, et al. Single nucleotide polymorphism of TCF7L2 and Adiponectin genes for type 2 diabetes mellitus in Taiwan. Fooyin J Health Sci. 2009;1:41-7.
33. Habalova V, Klimcakova L, Zidzik J, Tkac I. Rapid cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes. Mol Cell Probes. 2009;23:52-4.