High-level activation by a duodenum-specific enhancer requires functional GATA binding sites

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 6 47-6, 2003, Pages

  Dusing, Mary R ^a   Florence, Elizabeth A ^a   Wiginton, Dan A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adenosine deaminase; GATA 4; Intestinal epithelium; Intestine

Indexed keywords

ADENOSINE DEAMINASE; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 5; TRANSCRIPTION FACTOR GATA 6;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INTESTINE VILLUS; INTRON; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA ISOLATION; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE;

EID: 0038585210     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00483.2002     Document Type: Article

References (60)

1. Arceci RJ, King AA, Simon MC, Orkin SH, and Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol 13: 2235-2246, 1993.
2. Aronow BJ, Silbiger RN, Dusing MR, Stock JL, Yager KL, Potter SS, Hutton JJ, and Wiginton DA. Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression. Mol Cell Biol 12: 4170-4185, 1992.
3. Atchison ML. Enhancers: mechanisms of action and cell specificity. Annu Rev Cell Biol 4: 127-153, 1988.
4. Bates MD, Erwin CR, Sanford LP, Wiginton D, Bezerra JA, Schatzman LC, Jegga AG, Ley-Ebert C, Williams SS, Steinbrecher KA, Warner BW, Cohen MB, and Aronow BJ. Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology 122: 1467-1482, 2002.
5. Bhalla SS, Robitaille L, and Nemer M. Cooperative activation by GATA-4 and YY1 of the cardiac B-type natriuretic peptide promoter. J Biol Chem 276: 11439-11445, 2001.
6. Blackburn MR and Kellems RE. Regulation and function of adenosine deaminase in mice. Prog Nucleic Acid Res Mol Biol 55: 195-226, 1996.
7. Bossard P and Zaret KS. GATA transcription factors as potentiators of gut endoderm differentiation. Development 125: 4909-4917, 1998.
8. Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, and Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277: 31909-31917, 2002.
9. Brickner A, Gossage D, Dusing M, and Wiginton D. Identification of a murine homolog of the human adenosine deaminase thymic enhancer. Gene 167: 261-266, 1995.
10. Carey M. The enhanceosome and transcriptional synergy. Cell 92: 5-8, 1998.
11. Charron F, Tsimiklis G, Areand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, and Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev 15: 2702-2719, 2001.
12. Cirillo LA, Lin FR, Cuesta I, Friedman D, Jarnik M, and Zaret KS. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell 9: 279-289, 2002.
13. Clatworthy JP and Subramanian V. Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies. Mech Dev 101: 3-9, 2001.
14. Dai YS and Markham BE. p300 functions as a coactivator of transcription factor GATA-4. J Biol Chem 276: 37178-37185, 2001.
15. Dusing MR, Brickner AG, Lowe SY, Cohen MB, and Wiginton DA. A duodenum-specific enhancer regulates expression along three axes in the small intestine. Am J Physiol Gastrointest Liver Physiol 279: G1080-G1093, 2000.
16. Dusing MR, Brickner AG, Thomas MB, and Wiginton DA. Regulation of duodenal specific expression of the human adenosine deaminase gene. J Biol Chem 272: 26634-26642, 1997.
17. Dusing MR, Florence EA, and Wiginton DA. Pdx-1 is required for activation in vivo from a duodenum-specific enhancer. J Biol Chem 276: 14434-14442, 2001.
18. Fang R, Olds LC, Santiago NA, and Sibley E. GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 280: G58-G67, 2001.
19. Fitzgerald K, Bazar L, and Avigan MI. GATA-6 stimulates a cell line-specific activation element in the human lactase promoter. Am J Physiol Gastrointest Liver Physiol 274: G314-G324, 1998.
20. Gao X, Sedgwick T, Shi YB, and Evans T. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol 18: 2901-2911, 1998.
21. Gross DS and Garrard WT. Nuclease hypersensitive sites in chromatin. Annu Rev Biochem 57: 159-197, 1988.
22. Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, and Teitelman G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18, 1995.
23. Haynes TL, Thomas MB, Dusing MR, Valerius MT, Potter SS, and Wiginton DA. An enhancer LEF-1/TCF-1 site is essential for insertion-site independent transgene expression in thymus. Nucleic Acids Res 24: 5034-5044, 1996.
24. Heller RS, Stoffers DA, Hussain MA, Miller CP, and Habener JF. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology 115: 381-387, 1998.
25. Jacobsen CM, Narita N, Bielinska M, Syder AJ, Gordon JI, and Wilson DB. Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol 241: 34-46, 2002.
26. Kakita T, Hasegawa K, Morimoto T, Kaburagi S, Wada H, and Sasayama S. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. J Biol Chem 274: 34096-34102, 1999.
27. Ko LJ and Engel JD. DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol 13: 4011-4022, 1993.
28. Koutsourakis M, Langeveld A, Patient R, Beddington R, and Grosveld F. The transcription factor GATA6 is essential for early extraembryonic development. Development 126: 723-732, 1999.
29. Krasinski SD, Van Wering HM, Tannemaat MR, and Grand RJ. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am J Physiol Gastrointest Liver Physiol 281: G69-G84, 2001.
30. Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, and Leiden JM. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11: 1048-1060, 1997.
31. Laverriere AC, MacNeill C, Mueller C, Poelmann RE, Burch JB, and Evans T. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J Biol Chem 269: 23177-23184, 1994.
32. Lemon B and Tjian R. Orchestrated response: a symphony of transcription factors for gene control. Genes Dev 14: 2551-2569, 2000.
33. Leonard J, Peers B, Johnson T, Ferreri K, Lee S, and Montminy MR. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7: 1275-1283, 1993.
34. Liang Q, Wiese RJ, Bueno OF, Dai YS, Markham BE, and Molkentin JD. The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Mol Cell Biol 21: 7460-7469, 2001.
35. Maniatis T, Goodbourn S, and Fischer JA. Regulation of inducible and tissue-specific gene expression. Science 236: 1237-1245, 1987.
36. Merika M and Orkin SH. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13: 3999-4010, 1993.
37. Migchielsen AA, Breuer ML, van Roon MA, te Riele H, Zurcher C, Ossendorp F, Toutain S, Hershfield MS, Berns A, and Valerio D. Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet 10: 279-287, 1995.
38. Miller CP, McGehee RE Jr, and Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 13: 1145-1156, 1994.
39. Mitchell PJ and Tjian R. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245: 371-378, 1989.
40. Molkentin JD. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissuespecific gene expression. J Biol Chem 275: 38949-38952, 2000.
41. Molkentin JD, Lin Q, Duncan SA, and Olson EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11: 1061-1072, 1997.
42. Molkentin JD, Tymitz KM, Richardson JA, and Olson EN. Abnormalities of the genitourinary tract in female mice lacking GATA5. Mol Cell Biol 20: 5256-5260, 2000.
43. Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Wada H, Yanazume T, and Sasayama S. Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes. J Biol Chem 275: 13721-13726, 2000.
44. Morrisey EE, Ip HS, Lu MM, and Parmacek MS. GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177: 309-322, 1996.
45. Morrisey EE, Ip HS, Tang Z, Lu MM, and Parmacek MS. GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol 183: 21-36, 1997.
46. Morrisey EE, Tang Z, Sigrist K, Lu MM, Jiang F, Ip HS, and Parmacek MS. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev 12: 3579-3590, 1998.
47. Ohlsson H, Karlsson K, and Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12: 4251-4259, 1993.
48. Potten CS, Booth C, and Pritchard DM. The intestinal epithelial stem cell: the mucosal governor. Int J Exp Pathol 78: 219-243, 1997.
49. Potten CS and Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110: 1001-1020, 1990.
50. Shi D, Winston JH, Blackburn MR, Datta SK, Hanten G, and Kellems RE. Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta. J Biol Chem 272: 2334-2341, 1997.
51. Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, and Wilson DB. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121: 3877-3888, 1995.
52. Thanos D and Maniatis T. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83: 1091-1100, 1995.
53. Traber PG and Silberg DG. Intestine-specific gene transcription. Annu Rev Physiol 58: 275-297, 1996.
54. Van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EH, Grand RJ, and Krasinski SD. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J Biol Chem 277: 27659-27667, 2002.
55. Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, and Sasayama S. A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene. J Biol Chem 275: 25330-25335, 2000.
56. Walters MC, Fiering S, Eidemiller J, Magis W, Groudine M, and Martin DI. Enhancers increase the probability but not the level of gene expression. Proc Natl Acad Sci USA 92: 7125-7129, 1995.
57. Winston JH, Hong L, Datta SK, and Kellems RE. An intron 1 regulatory region from the murine adenosine deaminase gene can activate heterologous promoters for ubiquitous expression in transgenic mice. Somat Cell Mol Genet 22: 261-278, 1996.
58. Witte DP, Wiginton DA, Hutton JJ, and Aronow BJ. Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and postimplantation reproductive tracts. J Cell Biol 115: 179-190, 1991.
59. Xu PA and Kellems RE. Function of murine adenosine deaminase in the gastrointestinal tract. Biochem Biophys Res Commun 269: 749-757, 2000.
60. Xu PA, Winston JH, Datta SK, and Kellems RE. Regulation of forestomach-specific expression of the murine adenosine deaminase gene. J Biol Chem 274: 10316-10323, 1999.