Type i and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

Journal of Neurochemistry

Volumn 123, Issue 1, 2012, Pages 73-83

  Thomsen, Morten S ^a   Mikkelsen, Jens D ^a  

^a Mental Health Services CPH   (Denmark)

Author keywords

7; allosteric modulator; desensitization; nicotinic acetylcholine receptor; up regulation

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 3 (2 CHLORO 5 TRIFLUOROMETHYLPHENYL)UREA; 1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYLISOXAZOL 3 YL)UREA; 2 METHYL 5(6 PHENYLPYRIDAZIN 3 YL)OCTAHYDRO PYRROLO[3,4C]PYRROLE; BUNGAROTOXIN RECEPTOR; NICOTINE; NICOTINIC AGENT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DESENSITIZATION; FRONTAL CORTEX; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; UPREGULATION;

ALLOSTERIC REGULATION; ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; BRAIN; BUNGAROTOXINS; CHOLINERGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; IODINE ISOTOPES; L-LACTATE DEHYDROGENASE; MALE; NICOTINE; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; TRANSFECTION; UP-REGULATION;

EID: 84866262408     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07876.x     Document Type: Article

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