Screening for multiple phosphodiesterase type 5 inhibitor drugs in dietary supplement materials by flow injection mass spectrometry and their quantification by liquid chromatography tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 40-46

  Song, Fenhong ^a   El Demerdash, Aref ^a   Lee, Shwn Ji Susie H ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Flow injection; LC MS MS; Phosphodiesterase type 5 inhibitor; Sildenafil; Tadalafil

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; TADALAFIL; VARDENAFIL;

ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG SCREENING; DRUG STRUCTURE; FLOW INJECTION ANALYSIS; FRAGMENTATION REACTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; PRESCRIPTION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TEMPERATURE;

CARBOLINES; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; DRUG CONTAMINATION; FLOW INJECTION ANALYSIS; IMIDAZOLES; MASS SPECTROMETRY; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PLANT PREPARATIONS; PURINES; SULFONES; TANDEM MASS SPECTROMETRY; TRIAZINES;

EID: 84866261665     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.05.017     Document Type: Article

References (23)

1. Gratz S.R., Flurer C.L., Wolnik K.A. Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV. J. Pharm. Biomed. Anal. 2004, 36:525-533.
2. Lee H.M., Lee B.J. A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method. Food Addit. Contam. Part A 2011, 28:396-407.
3. Ng C.S., Law T.Y., Cheung Y.K., Ng P.C., Choi K.K. Development of a screening method for the detection of analogues of sildenafil and vardenafil by the use of liquid chromatograph coupled with triple quadrupole linear ion trap mass spectrometer. Anal. Methods 2010, 2:890-896.
4. Bogusz M.J., Hassan H., Ai-Enazi E., Ibrahim Z., Al-Tufail M. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. J. Pharm. Biomed. Anal. 2006, 41:554-564.
5. Liang Q., Qu L.J., Luo G.A., Wang Y.M. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. J. Pharm. Biomed. Anal. 2006, 40:305-311.
6. Man C.N., Nor N.M., Lajis R., Harn G.L. Identification of sildenafil, tadalafil and vardenafil by gas chromatography-mass spectrometry on short capillary column. J. Chromatogr. A 2009, 1216:8426-8430.
7. Balayssac S., Trefi S., Gilard V., Malet-Martino M., Martino R., Delsuc M.A. 2D and 3D DOSY (1)H NMR, a useful tool for analysis of complex mixtures: application to herbal drugs or dietary supplements for erectile dysfunction. J. Pharm. Biomed. Anal. 2009, 50:602-612.
8. Trefi S., Gilard V., Balayssac S., Malet-Martino M., Martino R. The usefulness of 2D DOSY and 3D DOSY-COSY (1)H NMR for mixture analysis: application to genuine and fake formulations of sildenafil (viagra). Magn. Reson. Chem. 2009, 47:S163-S173.
9. Gryniewicz C.M., Reepmeyer J.C., Kauffman J.F., Buhse L.F. Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry. J. Pharm. Biomed. Anal. 2009, 49:601-606.
10. Song F., El-Demerdash A., Lee S., Smith R.E. Fast screening of lovastatin in red yeast rice products by flow injection tandem mass spectrometry. J. Pharm. Biomed. Anal. 2012, 57:76-81.
11. Nanita S.C., Pentz A.M., Bramble F.Q. High-throughput pesticide residue quantitative analysis achieved by tandem mass spectrometry with automated flow injection. Analyt. Chem. 2009, 81:3134-3142.
12. Zhong D.F., Xing J., Zhang S.Q., Sun L. Study of the electrospray ionization tandem mass spectrometry of sildenafil derivatives. Rapid Commun. Mass Spectrom. 2002, 16:1836-1843.
13. Gratz S.R., Gamble B.M., Flurer R.A. Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices. Rapid Commun. Mass Spectrom. 2006, 20:2317-2327.
14. Ahn S., Hong J.Y., Hong M.K., Jang Y.P., Oh M.S., Jung J.H., Hong J. Structural determination of sildenafil and its analogues in dietary supplements by fast-atom bombardment collision-induced dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:3158-3166.
15. Blok-Tip L., Zomer B., Bakker F., Hartog K.D., Hamzink M., ten Hove J., Vredenbregt M., de Kaste D. Structure elucidation of sildenafil analogues in herbal products. Food Addit. Contam. 2004, 21:737-748.
16. Gratz S.R., Zeller M., Mincey D.W., Flurer C.L. Structural characterization of sulfoaildenafil, an analog of sildenafil. J. Pharm. Biomed. Anal. 2009, 50:228-231.
17. Lin M.C., Liu Y.C., Lin Y.L., Lin J.H. Identification of a tadalafil analogue adulterated in a dietary supplement. J. Food Drug Anal. 2009, 17:451-458.
18. Shin M.H., Hong M.K., Kim W.S., Lee Y.J., Jeoung Y.C. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food Addit. Contamin. 2003, 20:793-796.
19. Lai K.C., Liu Y.C., Tseng M.C., Lin Y.L., Lin J.H. Isolation and identification of a vardenafil analogue in a functional food marketed for penile erectile dysfunction. J. Food Drug Anal. 2007, 15:133-138.
20. Park H.J., Jeong H.K., Chang M.I., Im M.H., Jeong J.Y., Choi D.M., Park K., Hong M.K., Youm J., Han S.B., Kim D.J., Park J.H., Kwon S.W. Structure determination of new analogues of vardenafil and sildenafil in dietary supplements. Food Addit. Contam. 2007, 24:122-129.
21. Zou P., Hou P., Oh S.S.Y., Ge X., Bloodworth B.C., Low M.Y., Koh H.L. Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement. J. Pharm. Biomed. Anal. 2008, 47:255-259.
22. Reepmeyer J.C., d'Avignon D.A. Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs. J. Pharm. Biomed. Anal. 2009, 49:145-150.
23. Reepmeyer J.C., Woodruff J.T., d'Avigno D.A. Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement. J. Pharm. Biomed. Anal. 2007, 43:1615-1621.