Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5550-5558

  Linsky, Thomas W ^a   Fast, Walter ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Dimethylarginine dimethylaminohydrolase; Fragment library; High throughput screen; Inhibitor discovery; Nitric oxide

Indexed keywords

2 (1,3 BENZOXAZOL 2 YLTHIO)ETHANAMINE; 2 ETHYL BENZIMIDAZOLE; 2 HYDROXYMETHYL 4 CHLOROPYRIDINE; 2 METHYL 4 BROMOPYRIDINE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE INHIBITOR; ENZYME INHIBITOR; ISOENZYME; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR DOCKING; MOLECULAR LIBRARY; PSEUDOMONAS AERUGINOSA; VALIDATION PROCESS;

AMIDOHYDROLASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

PSEUDOMONAS AERUGINOSA;

EID: 84866257831     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.022     Document Type: Article

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