Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1

ChemMedChem

Volumn 6, Issue 1, 2011, Pages 81-88

  Lluis, Matthew ^a,b   Wang, Yun ^a   Monzingo, Arthur F ^a   Fast, Walter ^a   Robertus, Jon D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b 1 University Station ^*  (United States)

Author keywords

Activity probes; Covalent reversible; DDAH; Inhibitors; Nitric oxide

Indexed keywords

AMIDINE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; ENZYME INHIBITOR; N 5 (1 IMINOPENTYL) LEVO ORNITHINE; NITRIC OXIDE; ORNITHINE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL CULTURE; CELL STRAIN HEK293; CONFORMATION; COVALENT BOND; DISSOCIATION CONSTANT; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; WILD TYPE; X RAY CRYSTALLOGRAPHY;

AMIDINES; AMINOHYDROLASES; ARGININE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; KINETICS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

EID: 78650540087     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000392     Document Type: Article

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