On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines

Journal of the American Chemical Society

Volumn 133, Issue 28, 2011, Pages 10951-10959

  Johnson, Corey M ^a   Monzingo, Arthur F ^a   Ke, Zhihong ^b   Yoon, Dae Wi ^a   Linsky, Thomas W ^a   Guo, Hua ^b   Robertus, Jon D ^a   Fast, Walter ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL PROBES; COVALENT ATTACHMENT; COVALENT BOND FORMATION; DIMETHYLARGININE; ENHANCED REACTIVITY; INACTIVATION MECHANISMS; IRREVERSIBLE INACTIVATION; NOVEL PROTEINS; PROTEIN MODIFICATIONS; PYRIDINIUM; RELATED COMPOUNDS; SMALL MOLECULES; SOLUTION STUDY; STRUCTURAL MODELS; STRUCTURAL STUDIES; TARGET PROTEINS; X RAY CRYSTAL STRUCTURES;

METHANOL; MODEL STRUCTURES; NITRIC OXIDE; PROTEINS;

CRYSTAL ORIENTATION;

2 METHYL 4 BROMOPYRIDINE; 4 HALOPYRIDINE; CYSTEINE; DIMETHYLARGININASE; HALIDE; NITRIC OXIDE; PYRIDINE DERIVATIVE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BINDING; CHEMICAL INTERACTION; CHEMICAL REACTION; CHEMICAL STRUCTURE; COVALENT BOND; ENZYME INACTIVATION; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; CATALYTIC DOMAIN; ENZYME ACTIVATION; ENZYME INHIBITORS; HALOGENATION; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; PYRIDINES; SOLUTIONS;

EID: 79960281532     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2033684     Document Type: Article

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