Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator

ACS Medicinal Chemistry Letters

Volumn 2, Issue 8, 2011, Pages 592-596

  Linsky, Thomas ^a   Wang, Yun ^a   Fast, Walter ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

covalent inhibitors; Dimethylarginine dimethylaminohydrolase; ebselen; high throughput screening; nitric oxide

Indexed keywords

CEFATRIZINE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE INHIBITOR; DISULFIRAM; EBSELEN; HYDROLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INACTIVATION; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR DOCKING; MOLECULAR LIBRARY; PRIORITY JOURNAL;

EID: 80051731140     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2000824     Document Type: Article

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