메뉴 건너뛰기




Volumn 2012, Issue , 2012, Pages

Cardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain fatty acid uptake and de novo fatty acid synthesis

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; CD36 ANTIGEN; FATTY ACID TRANSPORTER 4; GLUCOSE; INSULIN; LEPTIN; LONG CHAIN FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRIACYLGLYCEROL;

EID: 84866253984     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2012/205648     Document Type: Article
Times cited : (52)

References (61)
  • 1
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • DOI 10.1210/jc.2004-0535
    • Bray G. A., Medical consequences of obesity. Journal of Clinical Endocrinology and Metabolism 2004 89 6 2583 2589 2-s2.0-2942657650 10.1210/jc.2004-0535 (Pubitemid 38766335)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.6 , pp. 2583-2589
    • Bray, G.A.1
  • 2
    • 42049109696 scopus 로고    scopus 로고
    • Cardiac remodeling in obesity
    • DOI 10.1152/physrev.00017.2007
    • Abel E. D., Litwin S. E., Sweeney G., Cardiac remodeling in obesity. Physiological Reviews 2008 88 2 389 419 2-s2.0-42049109696 10.1152/physrev. 00017.2007 (Pubitemid 351520084)
    • (2008) Physiological Reviews , vol.88 , Issue.2 , pp. 389-419
    • Abel, E.D.1    Litwin, S.E.2    Sweeney, G.3
  • 3
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • DOI 10.1002/hep.21327
    • Ekstedt M., Franzén L. E., Mathiesen U. L., Thorelius L., Holmqvist M., Bodemar G., Kechagias S., Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006 44 4 865 873 2-s2.0-33750606061 10.1002/hep.21327 (Pubitemid 46489550)
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3    Thorelius, L.4    Holmqvist, M.5    Bodemar, G.6    Kechagias, S.7
  • 4
    • 33947366047 scopus 로고    scopus 로고
    • Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: The Hoorn Study
    • DOI 10.1111/j.1464-5491.2007.02100.x
    • Schindhelm R. K., Dekker J. M., Nijpels G., Stehouwer C. D. A., Bouter L. M., Heine R. J., Diamant M., Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study. Diabetic Medicine 2007 24 4 430 435 2-s2.0-33947366047 10.1111/j.1464-5491.2007.02100.x (Pubitemid 46452402)
    • (2007) Diabetic Medicine , vol.24 , Issue.4 , pp. 430-435
    • Schindhelm, R.K.1    Dekker, J.M.2    Nijpels, G.3    Stehouwer, C.D.A.4    Bouter, L.M.5    Heine, R.J.6    Diamant, M.7
  • 5
    • 77957371584 scopus 로고    scopus 로고
    • Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice
    • 2-s2.0-77957371584 10.1152/ajpgi.00434.2009
    • Ge F., Zhou S., Hu C., Lobdell H., Berk P. D., Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. American Journal of Physiology 2010 299 4 G855 G866 2-s2.0-77957371584 10.1152/ajpgi.00434.2009
    • (2010) American Journal of Physiology , vol.299 , Issue.4
    • Ge, F.1    Zhou, S.2    Hu, C.3    Lobdell, H.4    Berk, P.D.5
  • 7
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • 2-s2.0-70449158340
    • Folch J., Lees M., Sloane Stanley G. H., A simple method for the isolation and purification of total lipides from animal tissues. The Journal of biological chemistry 1957 226 1 497 509 2-s2.0-70449158340
    • (1957) The Journal of Biological Chemistry , vol.226 , Issue.1 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 9
    • 0017279676 scopus 로고
    • Problems in echocardiographic volume determinations: Echocardiographic angiographic correlations in the presence or absence of asynergy
    • 2-s2.0-0017279676
    • Teichholz L. E., Kreulen T., Herman M. V., Gorlin R., Problems in echocardiographic volume determinations: echocardiographic angiographic correlations in the presence or absence of asynergy. American Journal of Cardiology 1976 37 1 7 11 2-s2.0-0017279676
    • (1976) American Journal of Cardiology , vol.37 , Issue.1 , pp. 7-11
    • Teichholz, L.E.1    Kreulen, T.2    Herman, M.V.3    Gorlin, R.4
  • 10
  • 11
    • 0019473002 scopus 로고
    • Oxygen requirements, morphology, cell coat and membrane permeability of calcium-tolerant myocytes from hearts of adult rats
    • Wittenberg B. A., Robinson T. F., Oxygen requirements, morphology, cell coat and membrane permeability of calcium-tolerant myocytes from hearts of adult rats. Cell and Tissue Research 1981 216 2 231 251 2-s2.0-0019473002 (Pubitemid 11065204)
    • (1981) Cell and Tissue Research , vol.216 , Issue.2 , pp. 231-251
    • Wittenberg, B.A.1    Robinson, T.F.2
  • 13
    • 0023680059 scopus 로고
    • Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut
    • 2-s2.0-0023680059
    • Sorrentino D., Stump D., Potter B. J., Robinson R. B., White R., Kiang C. L., Berk P. D., Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut. Journal of Clinical Investigation 1988 82 3 928 935 2-s2.0-0023680059
    • (1988) Journal of Clinical Investigation , vol.82 , Issue.3 , pp. 928-935
    • Sorrentino, D.1    Stump, D.2    Potter, B.J.3    Robinson, R.B.4    White, R.5    Kiang, C.L.6    Berk, P.D.7
  • 15
    • 0347071124 scopus 로고
    • Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein
    • Stremmel W., Strohmeyer G., Berk P. D., Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein. Proceedings of the National Academy of Sciences of the United States of America 1986 83 11 3584 3588 2-s2.0-0347071124 (Pubitemid 16062329)
    • (1986) Proceedings of the National Academy of Sciences of the United States of America , vol.83 , Issue.11 , pp. 3584-3588
    • Stremmel, W.1    Strohmeyer, G.2    Berk, P.D.3
  • 16
    • 0024465886 scopus 로고
    • At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory
    • Sorrentino D., Robinson R. B., Kiang C. L., Berk P. D., At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory. Journal of Clinical Investigation 1989 84 4 1325 1333 2-s2.0-0024465886 (Pubitemid 19247607)
    • (1989) Journal of Clinical Investigation , vol.84 , Issue.4 , pp. 1325-1333
    • Sorrentino, D.1    Robinson, R.B.2    Kiang, C.-L.3    Berk, P.D.4
  • 17
    • 0035059742 scopus 로고    scopus 로고
    • Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake
    • Stump D. D., Fan X., Berk P. D., Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake. Journal of Lipid Research 2001 42 4 509 520 2-s2.0-0035059742 (Pubitemid 32366993)
    • (2001) Journal of Lipid Research , vol.42 , Issue.4 , pp. 509-520
    • Stump, D.D.1    Fan, X.2    Berk, P.D.3
  • 18
    • 0032952704 scopus 로고    scopus 로고
    • Mechanisms of cellular uptake of long chain free fatty acids
    • Berk P. D., Stump D. D., Mechanisms of cellular uptake of long chain free fatty acids. Molecular and Cellular Biochemistry 1999 192 1-2 17 31 2-s2.0-0032952704 (Pubitemid 29171450)
    • (1999) Molecular and Cellular Biochemistry , vol.192 , Issue.1-2 , pp. 17-31
    • Berk, P.D.1    Stump, D.D.2
  • 19
    • 0030991677 scopus 로고    scopus 로고
    • Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus
    • DOI 10.1074/jbc.272.13.8830
    • Berk P. D., Zhou S. L., Kiang C. L., Stump D., Bradbury M., Isola L. M., Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. Journal of Biological Chemistry 1997 272 13 8830 8835 2-s2.0-0030991677 10.1074/jbc.272.13.8830 (Pubitemid 27147855)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.13 , pp. 8830-8835
    • Berk, P.D.1    Zhou, S.-L.2    Kiang, C.-L.3    Stump, D.4    Bradbury, M.5    Isola, L.M.6
  • 20
    • 0033214662 scopus 로고    scopus 로고
    • Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents
    • DOI 10.1074/jbc.274.40.28626
    • Berk P. D., Zhou S. L., Kiang C. L., Stump D. D., Fan X., Bradbury M. W., Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. Journal of Biological Chemistry 1999 274 40 28626 28631 2-s2.0-0033214662 10.1074/jbc.274.40.28626 (Pubitemid 29472993)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.40 , pp. 28626-28631
    • Berk, P.D.1    Zhou, S.-L.2    Kiang, C.-L.3    Stump, D.D.4    Fan, X.5    Bradbury, M.W.6
  • 21
    • 33646839278 scopus 로고    scopus 로고
    • Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings
    • Berk P. D., Zhou S., Bradbury M. W., Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. Transactions of the American Clinical and Climatological Association 2005 116 335 344
    • (2005) Transactions of the American Clinical and Climatological Association , vol.116 , pp. 335-344
    • Berk, P.D.1    Zhou, S.2    Bradbury, M.W.3
  • 22
    • 13244292279 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity
    • DOI 10.1038/sj.ijo.0802868
    • Petrescu O., Fan X., Gentileschi P., Hossain S., Bradbury M., Gagner M., Berk P. D., Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. International Journal of Obesity 2005 29 2 196 203 2-s2.0-13244292279 10.1038/sj.ijo.0802868 (Pubitemid 40188415)
    • (2005) International Journal of Obesity , vol.29 , Issue.2 , pp. 196-203
    • Petrescu, O.1    Fan, X.2    Gentileschi, P.3    Hossain, S.4    Bradbury, M.5    Gagner, M.6    Berk, P.D.7
  • 24
    • 13944280432 scopus 로고    scopus 로고
    • Seatle, Wash, USA SAAM Institute
    • SAAMII User Guide 1998 Seatle, Wash, USA SAAM Institute
    • (1998) SAAMII User Guide
  • 25
    • 46249111052 scopus 로고    scopus 로고
    • A mouse model of metabolic syndrome; Increase in visceral adipose tissue precedes the development of fatty liver and insulin resistance in high-fat diet-fed male KK/Ta mice
    • DOI 10.3164/jcbn.2008022
    • Akagiri S., Naito Y., Ichikawa H., Mizushima K., Takagi T., Handa O., Kokura S., Yoshikawa T., A mouse model of metabolic syndrome; Increase in visceral adipose tissue precedes the development of fatty liver and insulin resistance in high-fat diet-fed male KK/Ta mice. Journal of Clinical Biochemistry and Nutrition 2008 42 2 150 157 2-s2.0-46249111052 10.3164/jcbn.2008022 (Pubitemid 351912434)
    • (2008) Journal of Clinical Biochemistry and Nutrition , vol.42 , Issue.2 , pp. 150-157
    • Akagiri, S.1    Naito, Y.2    Ichikawa, H.3    Mizushima, K.4    Takagi, T.5    Handa, O.6    Kokura, S.7    Yoshikawa, T.8
  • 26
    • 0027077992 scopus 로고
    • Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes
    • DOI 10.1016/S0168-8278(05)80661-0
    • Stump D. D., Nunes R. M., Sorrentino D., Isola L. M., Berk P. D., Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes. Journal of Hepatology 1992 16 3 304 315 2-s2.0-0027077992 10.1016/S0168-8278(05)80661-0 (Pubitemid 23013222)
    • (1992) Journal of Hepatology , vol.16 , Issue.3 , pp. 304-315
    • Stump, D.D.1    Nunes, R.M.2    Sorrentino, D.3    Isola, L.M.4    Berk, P.D.5
  • 27
    • 66349126859 scopus 로고    scopus 로고
    • Regulation of fatty acid uptake into tissues: Lipoprotein lipase- and CD36-mediated pathways
    • 10.1194/jlr.R800085-JLR200
    • Goldberg I. J., Eckel R. H., Abumrad N. A., Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. Journal of lipid research 2009 50 S86 S90 10.1194/jlr.R800085-JLR200
    • (2009) Journal of Lipid Research , vol.50
    • Goldberg, I.J.1    Eckel, R.H.2    Abumrad, N.A.3
  • 28
    • 73949158708 scopus 로고    scopus 로고
    • Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization
    • 2-s2.0-73949158708 10.1007/s11695-009-0002-9
    • Walewski J. L., Ge F., Gagner M., Inabnet W. B., Pomp A., Branch A. D., Berk P. D., Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization. Obesity Surgery 2010 20 1 93 107 2-s2.0-73949158708 10.1007/s11695-009-0002-9
    • (2010) Obesity Surgery , vol.20 , Issue.1 , pp. 93-107
    • Walewski, J.L.1    Ge, F.2    Gagner, M.3    Inabnet, W.B.4    Pomp, A.5    Branch, A.D.6    Berk, P.D.7
  • 37
    • 34547562750 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Pathogenesis and pathophysiology
    • DOI 10.1038/ncpcardio0943, PII NCPCARDIO0943
    • Wong C., Marwick T. H., Obesity cardiomyopathy: pathogenesis and pathophysiology. Nature Clinical Practice Cardiovascular Medicine 2007 4 8 436 443 2-s2.0-34547562750 10.1038/ncpcardio0943 (Pubitemid 47189016)
    • (2007) Nature Clinical Practice Cardiovascular Medicine , vol.4 , Issue.8 , pp. 436-443
    • Wong, C.1    Marwick, T.H.2
  • 38
    • 34548216360 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Diagnosis and therapeutic implications
    • DOI 10.1038/ncpcardio0964, PII NCPCARDIO0964
    • Wong C., Marwick T. H., Obesity cardiomyopathy: diagnosis and therapeutic implications. Nature Clinical Practice Cardiovascular Medicine 2007 4 9 480 490 2-s2.0-34548216360 10.1038/ncpcardio0964 (Pubitemid 47321548)
    • (2007) Nature Clinical Practice Cardiovascular Medicine , vol.4 , Issue.9 , pp. 480-490
    • Wong, C.1    Marwick, T.H.2
  • 40
    • 0033662461 scopus 로고    scopus 로고
    • Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
    • Belke D. D., Larsen T. S., Gibbs E. M., Severson D. L., severson@ucalgary.ca Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. American Journal of Physiology 2000 279 5 E1104 E1113
    • (2000) American Journal of Physiology , vol.279 , Issue.5
    • Belke, D.D.1    Larsen, T.S.2    Gibbs, E.M.3    Severson, D.L.4
  • 44
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • DOI 10.1146/annurev.physiol.70.113006.100707
    • Myers M. G., Cowley M. A., Münzberg H., Mechanisms of leptin action and leptin resistance. Annual Review of Physiology 2008 70 537 556 2-s2.0-43549114292 10.1146/annurev.physiol.70.113006.100707 (Pubitemid 351738191)
    • (2008) Annual Review of Physiology , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 45
    • 33645978418 scopus 로고    scopus 로고
    • Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease
    • 2-s2.0-33645978418 10.1053/j.gastro.2006.02.040
    • Goldberg I. J., Ginsberg H. N., Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease. Gastroenterology 2006 130 4 1343 1346 2-s2.0-33645978418 10.1053/j.gastro.2006. 02.040
    • (2006) Gastroenterology , vol.130 , Issue.4 , pp. 1343-1346
    • Goldberg, I.J.1    Ginsberg, H.N.2
  • 46
    • 56649115813 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of obesity and fatty liver: Impact of bariatric surgery
    • 2-s2.0-56649115813 10.1055/s-0028-1091985
    • Verna E. C., Berk P. D., Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery. Seminars in Liver Disease 2008 28 4 407 426 2-s2.0-56649115813 10.1055/s-0028-1091985
    • (2008) Seminars in Liver Disease , vol.28 , Issue.4 , pp. 407-426
    • Verna, E.C.1    Berk, P.D.2
  • 47
    • 56149127703 scopus 로고    scopus 로고
    • Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
    • 2-s2.0-56149127703 10.1002/hep.22632
    • Berk P. D., Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology 2008 48 5 1362 1376 2-s2.0-56149127703 10.1002/hep.22632
    • (2008) Hepatology , vol.48 , Issue.5 , pp. 1362-1376
    • Berk, P.D.1
  • 48
    • 0026702569 scopus 로고
    • Cardiomyopathy of obesity: A clinicopathologic evaluation of 43 obese patients with heart failure
    • 2-s2.0-0026702569 10.1016/0002-9149(92)90739-L
    • Kasper E. K., Hruban R. H., Baughman K. L., Cardiomyopathy of obesity: a clinicopathologic evaluation of 43 obese patients with heart failure. American Journal of Cardiology 1992 70 9 921 924 2-s2.0-0026702569 10.1016/0002-9149(92) 90739-L
    • (1992) American Journal of Cardiology , vol.70 , Issue.9 , pp. 921-924
    • Kasper, E.K.1    Hruban, R.H.2    Baughman, K.L.3
  • 49
    • 38649091680 scopus 로고    scopus 로고
    • Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
    • DOI 10.1002/hep.21983
    • Perseghin G., Lattuada G., De Cobelli F., Esposito A., Belloni E., Ntali G., Ragogna F., Canu T., Scifo P., Del Maschio A., Luzi L., Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. Hepatology 2008 47 1 51 58 2-s2.0-38649091680 10.1002/hep.21983 (Pubitemid 351171041)
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 51-58
    • Perseghin, G.1    Lattuada, G.2    De Cobelli, F.3    Esposito, A.4    Belloni, E.5    Ntali, G.6    Ragogna, F.7    Canu, T.8    Scifo, P.9    Del Maschio, A.10    Luzi, L.11
  • 50
    • 33751546348 scopus 로고    scopus 로고
    • Myocardial triglyceride content and epicardial fat mass in human obesity: Relationship to left ventricular function and serum free fatty acid levels
    • DOI 10.1210/jc.2006-0584
    • Kankaanpää M., Lehto H.-R., Pärkkä J. P., Komu M., Viljanen A., Ferrannini E., Knuuti J., Nuutila P., Parkkola R., Iozzo P., patricia.iozzo@ifc.cnr.it Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. Journal of Clinical Endocrinology and Metabolism 2006 91 11 4689 4695 10.1210/jc.2006-0584 (Pubitemid 44833458)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.11 , pp. 4689-4695
    • Kankaanpaa, M.1    Lehto, H.-R.2    Parkka, J.P.3    Komu, M.4    Viljanen, A.5    Ferrannini, E.6    Knuuti, J.7    Nuutila, P.8    Parkkola, R.9    Iozzo, P.10
  • 51
    • 38649109813 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease (NAFLD) and cardiac lipotoxicity: Another piece of the puzzle
    • DOI 10.1002/hep.22105
    • Bugianesi E., Nonalcoholic fatty liver disease (NAFLD) and cardiac lipotoxicity: another piece of the puzzle. Hepatology 2008 47 1 2 4 2-s2.0-38649109813 10.1002/hep.22105 (Pubitemid 351171032)
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 2-4
    • Bugianesi, E.1
  • 52
    • 33746640458 scopus 로고    scopus 로고
    • Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes
    • DOI 10.1152/physiol.00008.2006
    • Boudina S., Abel E. D., Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology 2006 21 4 250 258 2-s2.0-33746640458 10.1152/physiol.00008.2006 (Pubitemid 44156857)
    • (2006) Physiology , vol.21 , Issue.4 , pp. 250-258
    • Boudina, S.1    Abel, E.D.2
  • 53
    • 31544477999 scopus 로고    scopus 로고
    • Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice
    • DOI 10.1677/joe.1.06241
    • Dong F., Zhang X., Yang X., Esberg L. B., Yang H., Zhang Z., Culver B., Ren J., Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. Journal of Endocrinology 2006 188 1 25 36 2-s2.0-31544477999 10.1677/joe.1.06241 (Pubitemid 43159807)
    • (2006) Journal of Endocrinology , vol.188 , Issue.1 , pp. 25-36
    • Dong, F.1    Zhang, X.2    Yang, X.3    Esberg, L.B.4    Yang, H.5    Zhang, Z.6    Culver, B.7    Ren, J.8
  • 54
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • DOI 10.2337/db07-0481
    • Boudina S., Sena S., Theobald H., Sheng X., Wright J. J., Xia X. H., Aziz S., Johnson J. I., Bugger H., Zaha V. G., Abel E. D., Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 2007 56 10 2457 2466 2-s2.0-34548848059 10.2337/db07-0481 (Pubitemid 47523253)
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3    Sheng, X.4    Wright, J.J.5    Xia, X.H.6    Aziz, S.7    Johnson, J.I.8    Bugger, H.9    Zaha, V.G.10    Abel, E.D.11
  • 55
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - An engine out of fuel
    • DOI 10.1056/NEJMra063052
    • Neubauer S., The failing heartan engine out of fuel. New England Journal of Medicine 2007 356 11 1140 1151 2-s2.0-33947239659 10.1056/NEJMra063052 (Pubitemid 46425598)
    • (2007) New England Journal of Medicine , vol.356 , Issue.11 , pp. 1140-1151
    • Neubauer, S.1
  • 56
    • 33644672230 scopus 로고    scopus 로고
    • Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice
    • DOI 10.2337/diabetes.54.12.3530
    • Park S. Y., Cho Y. R., Kim H. J., Higashimori T., Danton C., Lee M. K., Dey A., Rothermel B., Kim Y. B., Kalinowski A., Russell K. S., Kim J. K., Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes 2005 54 12 3530 3540 2-s2.0-33644672230 10.2337/diabetes.54.12.3530 (Pubitemid 43334346)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3530-3540
    • Park, S.-Y.1    Cho, Y.-R.2    Kim, H.-J.3    Higashimori, T.4    Danton, C.5    Lee, M.-K.6    Dey, A.7    Rothermel, B.8    Kim, Y.-B.9    Kalinowski, A.10    Russell, K.S.11    Kim, J.K.12
  • 58
    • 33644838137 scopus 로고    scopus 로고
    • Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity
    • DOI 10.1161/01.RES.0000199348.10580.1d, PII 0000301220060106000018
    • Barouch L. A., Gao D., Chen L., Miller K. L., Xu W., Phan A. C., Kittleson M. M., Minhas K. M., Berkowitz D. E., Wei C., Hare J. M., Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research 2006 98 1 119 124 2-s2.0-33644838137 10.1161/01.RES.0000199348.10580.1d (Pubitemid 43970211)
    • (2006) Circulation Research , vol.98 , Issue.1 , pp. 119-124
    • Barouch, L.A.1    Gao, D.2    Chen, L.3    Miller, K.L.4    Xu, W.5    Phan, A.C.6    Kittleson, M.M.7    Minhas, K.M.8    Berkowitz, D.E.9    Wei, C.10    Hare, J.M.11
  • 59
    • 38949135755 scopus 로고    scopus 로고
    • Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
    • DOI 10.1042/CS20070166
    • Bugger H., Abel E. D., Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clinical Science 2008 114 3-4 195 210 2-s2.0-38949135755 10.1042/CS20070166 (Pubitemid 351293995)
    • (2008) Clinical Science , vol.114 , Issue.3-4 , pp. 195-210
    • Bugger, H.1    Abel, E.D.2
  • 60
    • 58149293410 scopus 로고    scopus 로고
    • PGC-1 α and ERR α target gene downregulation is a signature of the failing human heart
    • 10.1016/j.yjmcc.2008.10.025
    • Sihag S., Cresci S., Li A. Y., Sucharov C. C., Lehman J. J., jlehman@dom.wustl.edu PGC-1 α and ERR α target gene downregulation is a signature of the failing human heart. Journal of Molecular and Cellular Cardiology 2009 46 2 201 212 10.1016/j.yjmcc.2008.10.025
    • (2009) Journal of Molecular and Cellular Cardiology , vol.46 , Issue.2 , pp. 201-212
    • Sihag, S.1    Cresci, S.2    Li, A.Y.3    Sucharov, C.C.4    Lehman, J.J.5
  • 61
    • 77958021516 scopus 로고    scopus 로고
    • PGC-1 coactivators in cardiac development and disease
    • 2-s2.0-77958021516 10.1161/CIRCRESAHA.110.223818
    • Rowe G. C., Jiang A., Arany Z., PGC-1 coactivators in cardiac development and disease. Circulation Research 2010 107 7 825 838 2-s2.0-77958021516 10.1161/CIRCRESAHA.110.223818
    • (2010) Circulation Research , vol.107 , Issue.7 , pp. 825-838
    • Rowe, G.C.1    Jiang, A.2    Arany, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.