Brazilian propolis inhibits the differentiation of Th17 cells by inhibition of interleukin-6-induced phosphorylation of signal transducer and activator of transcription 3

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 5, 2012, Pages 803-809

  Okamoto, Yoshihiro ^a   Tanaka, Mayuri ^a   Fukui, Takashi ^a   Masuzawa, Toshiyuki ^a  

^a CHIBA INSTITUTE OF SCIENCE   (Japan)

Author keywords

Interleukin 17; Propolis; Signal transducer and activator of transcription 3; Supressors of cytokine signaling 3; Th17 cell

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PROPOLIS; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL POLARITY; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; FLOW CYTOMETRY; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPLEEN CELL; TH17 CELL;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BEES; BRAZIL; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; PHOSPHORYLATION; PROPOLIS; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS;

ANIMALIA; MUS;

EID: 84866252422     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2012.657304     Document Type: Article

References (34)

1. Tani, H., Hasumi, K., Tatefuji, T., Hashimoto, K., Koshino, H., Takahashi, S. Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cysleukotrienes. Bioorg Med Chem 2010, 18, 151-157
2. Marcucci, M.C., Ferreres, F., García-Viguera, C., Bankova, V.S., De Castro, S.L., Dantas, A.P., Valente, P.H., Paulino, N. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol 2001, 74, 105-112
3. Marcucci, M.C., Ferreres, F., Custódio, A.R., Ferreira, M.M., Bankova, V.S., García-Viguera, C., Bretz, W.A. Evaluation of phenolic compounds in Brazilian propolis from different geographic regions. Z Naturforsch, C, J Biosci 2000, 55, 76-81
4. Park, J.H., Lee, J.K., Kim, H.S., Chung, S.T., Eom, J.H., Kim, K.A., Chung, S.J., Paik, S.Y., Oh, H.Y. Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol 2004, 4, 429-436
5. Orsatti, C.L., Missima, F., Pagliarone, A.C., Bachiega, T.F., Búfalo, M.C., Araújo, J.P. Jr, Sforcin, J.M. Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytother Res 2010, 24, 1141-1146
6. Sy, L.B., Wu, Y.L., Chiang, B.L., Wang, Y.H., Wu, W.M. Propolis extracts exhibit an immunoregulatory activity in an OVA-sensitized airway inflammatory animal model. Int Immunopharmacol 2006, 6, 1053-1060
7. Borrelli, F., Maffia, P., Pinto, L., Ianaro, A., Russo, A., Capasso, F., Ialenti, A. Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 2002, 73 Suppl 1, S53-S63
8. Hu, F., Hepburn, H.R., Li, Y., Chen, M., Radloff, S.E., Daya, S. Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models. J Ethnopharmacol 2005, 100, 276-283
9. Jung, W.K., Lee, D.Y., Choi, Y.H., Yea, S.S., Choi, I., Park, S.G., Seo, S.K., Lee, S.W., Lee, C.M., Kim, S.K., Jeon, Y.J., Choi, I.W. Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma. Life Sci 2008, 82, 797-805
10. Korkina, L.G. Phenylpropanoids as naturally occurring antioxidants: From plant defense to human health. Cell Mol Biol (Noisy-le-grand) 2007, 53, 15-25
11. Burdock, G.A. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol 1998, 36, 347-363
12. Boukraâ, L., Sulaiman, S.A. Rediscovering the antibiotics of the hive. Recent Pat Antiinfect Drug Discov 2009, 4, 206-213
13. Aso, K., Kanno, S., Tadano, T., Satoh, S., Ishikawa, M. Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull 2004, 27, 727-730
14. Ishihara, M., Naoi, K., Hashita, M., Itoh, Y., Suzui, M. Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines. Oncol Rep 2009, 22, 349-354
15. Najafi, M.F., Vahedy, F., Seyyedin, M., Jomehzadeh, H.R., Bozary, K. Effect of the water extracts of propolis on stimulation and inhibition of different cells. Cytotechnology 2007, 54, 49-56
16. Tanaka, M., Okamoto, Y., Fukui, T., Masuzawa, T. Suppression of interleukin 17 production by Brazilian propolis in mice with collagen-induced arthritis. Inflammopharmacology 2012. DOI: 10.1007/s10787-011-0088-2
17. Iwakura, Y., Ishigame, H. The IL-23/IL-17 axis in inflammation. J Clin Invest 2006, 116, 1218-1222
18. Steinman, L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 2007, 13, 139-145
19. Harrington, L.E., Hatton, R.D., Mangan, P.R., Turner, H., Murphy, T.L., Murphy, K.M., Weaver, C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6, 1123-1132
20. Park, H., Li, Z., Yang, X.O., Chang, S.H., Nurieva, R., Wang, Y.H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., Dong, C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6, 1133-1141
21. Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., Oukka, M., Weiner, H.L., Kuchroo, V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441, 235-238
22. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24, 179-189
23. Mathur, A.N., Chang, H.C., Zisoulis, D.G., Stritesky, G.L., Yu, Q., O'Malley, J.T., Kapur, R., Levy, D.E., Kansas, G.S., Kaplan, M.H. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 2007, 178, 4901-4907
24. Yang, X.O., Panopoulos, A.D., Nurieva, R., Chang, S.H., Wang, D., Watowich, S.S., Dong, C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 2007, 282, 9358-9363
25. Yoshimura, A., Naka, T., Kubo, M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007, 7, 454-465
26. Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., Hirano, T. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 2008, 29, 628-636
27. Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Perez, N., Yasukawa, H., Van Snick, J., Yoshimura, A., Tedgui, A., Mallat, Z. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med 2009, 206, 2067-2077
28. Pappu, B.P., Dong, C. Measurement of interleukin-17. Curr Protoc Immunol 2007, Chapter 6, Unit 6.25
29. Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U.A., Murakami, M., Hirano, T. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol 2007, 19, 695-702
30. Cheung, K.W., Sze, D.M., Chan, W.K., Deng, R.X., Tu, W., Chan, G.C. Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation. J Ethnopharmacol 2011, 138, 463-471
31. Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B.M., Tato, C., Yoshimura, A., Hennighausen, L., O'Shea, J.J. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci USA 2006, 103, 8137-8142
32. Dagvadorj, J., Naiki, Y., Tumurkhuu, G., Noman, A.S., Iftakhar-EKhuda, I., Komatsu, T., Koide, N., Yoshida, T., Takashi Yokochi, Tumor necrosis factor-α augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation. Immunology 2010, 129, 97-104
33. Sforcin, J.M. Propolis and the immune system: A review. J Ethnopharmacol 2007, 113, 1-14
34. Veenbergen, S., Bennink, M.B., de Hooge, A.S., Arntz, O.J., Smeets, R.L., van den Berg, W.B., van de Loo, F.A. Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis. Arthritis Rheum 2008, 58, 3742-3752