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Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5637-5641

New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells

(5) Reiter, Christoph a Herrmann, Astrid a Çapci, Aysun a Efferth, Thomas b Tsogoeva, Svetlana B a

a UNIVERSITY OF ERLANGEN NUREMBERG (Germany)

b JOHANNES GUTENBERG UNIVERSITY (Germany)

Author keywords

Apoptosis; Artesunic acid; Chemotherapy; Drug design; Homodimers; Linker; Multidrug resistance; Reactive oxygen species

Indexed keywords

ARTEMISININ; ARTESUNATE; ARTESUNIC ACID HOMODIMER DERIVATIVE; CYTOTOXIC AGENT; DOXORUBICIN; HOMODIMER; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CHEMICAL BINDING; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYBRIDIZATION; IC 50; LEUKEMIA CELL; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; ARTEMISININS; CELL SURVIVAL; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES; TUMOR CELLS, CULTURED;

EID: 84866241856 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.07.015 Document Type: Article

Times cited : (46)

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