메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages

Therapeutic advancement of chronic lymphocytic leukemia

Author keywords

Chronic lymphocytic leukemia; Monoclonal antibodies; Treatment

Indexed keywords

ALEMTUZUMAB; BAFETINIB; BENDAMUSTINE; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; DASATINIB; DEXAMETHASONE; DINACICLIB; DOXORUBICIN; FLAVOPIRIDOL; FLUDARABINE; FOSTAMATINIB; IBRUTINIB; IDELALISIB; LENALIDOMIDE; LUMILIXIMAB; METHYLPREDNISOLONE; MITOXANTRONE; NAVITOCLAX; OBINUTUZUMAB; OFATUMUMAB; PENTOSTATIN; POMALIDOMIDE; PREDNISONE; RITUXIMAB; THALIDOMIDE; UNINDEXED DRUG; VINCRISTINE; XL 147;

EID: 84866174279     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-5-55     Document Type: Review
Times cited : (37)

References (111)
  • 1
    • 40749132494 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia
    • DOI 10.1016/S0140-6736(08)60456-0, PII S0140673608604560
    • Chronic lymphocytic leukaemia. Dighiero G, Hamblin TJ, Lancet 2008 371 1017 1029 10.1016/S0140-6736(08)60456-0 18358929 (Pubitemid 351389535)
    • (2008) The Lancet , vol.371 , Issue.9617 , pp. 1017-1029
    • Dighiero, G.1    Hamblin, T.2
  • 3
    • 69049109924 scopus 로고    scopus 로고
    • Update in the management of chronic lymphocytic leukemia
    • 10.1186/1756-8722-2-29 19619273
    • Update in the management of chronic lymphocytic leukemia. Maddocks KJ, Lin TS, J Hematol Oncol 2009 2 29 10.1186/1756-8722-2-29 19619273
    • (2009) J Hematol Oncol , vol.2 , pp. 29
    • Maddocks, K.J.1    Lin, T.S.2
  • 5
    • 70350720141 scopus 로고    scopus 로고
    • First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia
    • 10.1182/blood-2009-02-206185 19605849
    • First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia. Eichhorst BF, Busch R, Stilgenbauer S, Stauch M, Bergmann MA, Ritgen M, Kranzhofer N, Rohrberg R, Soling U, Burkhard O, et al. Blood 2009 114 3382 3391 10.1182/blood-2009-02-206185 19605849
    • (2009) Blood , vol.114 , pp. 3382-3391
    • Eichhorst, B.F.1    Busch, R.2    Stilgenbauer, S.3    Stauch, M.4    Bergmann, M.A.5    Ritgen, M.6    Kranzhofer, N.7    Rohrberg, R.8    Soling, U.9    Burkhard, O.10
  • 6
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • DOI 10.1158/1078-0432.CCR-07-1061
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Leoni LM, Bailey B, Reifert J, Bendall HH, Zeller RW, Corbeil J, Elliott G, Niemeyer CC, Clin Cancer Res 2008 14 309 317 10.1158/1078-0432.CCR-07-1061 18172283 (Pubitemid 351378007)
    • (2008) Clinical Cancer Research , vol.14 , Issue.1 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3    Bendall, H.H.4    Zeller, R.W.5    Corbeil, J.6    Elliott, G.7    Niemeyer, C.C.8
  • 7
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • 10.1200/JCO.2008.20.8389 19652068
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. Knauf WU, Lissichkov T, Aldaoud A, Liberati A, Loscertales J, Herbrecht R, Juliusson G, Postner G, Gercheva L, Goranov S, et al. J Clin Oncol 2009 27 4378 4384 10.1200/JCO.2008.20.8389 19652068
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3    Liberati, A.4    Loscertales, J.5    Herbrecht, R.6    Juliusson, G.7    Postner, G.8    Gercheva, L.9    Goranov, S.10
  • 8
    • 84867233652 scopus 로고    scopus 로고
    • Demographics, Treatment Patterns, Safety, and Real-World Effectiveness in Patients > =70 Years of Age with Chronic Lymphocytic Leukemia Receiving Bendamustine with or without Rituximab
    • Demographics, Treatment Patterns, Safety, and Real-World Effectiveness in Patients > =70 Years of Age with Chronic Lymphocytic Leukemia Receiving Bendamustine with or without Rituximab. Kolibaba KS, Joshi AD, Sterchele JA, Forsyth M, Alwon E, Beygi H, Kennealey GT, ASH Annual Meeting Abstracts 2011 118 3914
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 3914
    • Kolibaba, K.S.1    Joshi, A.D.2    Sterchele, J.A.3    Forsyth, M.4    Alwon, E.5    Beygi, H.6    Kennealey, G.T.7
  • 13
    • 77951628255 scopus 로고    scopus 로고
    • Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: A phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study)
    • 10.1200/JCO.2009.25.9630 20212251
    • Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: a phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study). Robak T, Jamroziak K, Gora-Tybor J, Stella-Holowiecka B, Konopka L, Ceglarek B, Warzocha K, Seferynska I, Piszcz J, Calbecka M, et al. J Clin Oncol 2010 28 1863 1869 10.1200/JCO.2009.25.9630 20212251
    • (2010) J Clin Oncol , vol.28 , pp. 1863-1869
    • Robak, T.1    Jamroziak, K.2    Gora-Tybor, J.3    Stella-Holowiecka, B.4    Konopka, L.5    Ceglarek, B.6    Warzocha, K.7    Seferynska, I.8    Piszcz, J.9    Calbecka, M.10
  • 15
    • 84867232821 scopus 로고    scopus 로고
    • Cladribine Alone and in Combination with Cyclophosphamide or Cyclophosphamide and Mitoxantrone in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL): Long-Term Follow-up of the the Polish Adult Leukemia Group (PALG CLL2) Study
    • Cladribine Alone and in Combination with Cyclophosphamide or Cyclophosphamide and Mitoxantrone in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL): Long-Term Follow-up of the the Polish Adult Leukemia Group (PALG CLL2) Study. Robak T, Blonski J, Jamroziak K, Calbecka M, Dwilewicz-Trojaczek J, Boguradzki P, Dmoszynska A, Kowal M, Kloczko J, Piszcz J, et al. ASH Annual Meeting Abstracts 2011 118 3915
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 3915
    • Robak, T.1    Blonski, J.2    Jamroziak, K.3    Calbecka, M.4    Dwilewicz-Trojaczek, J.5    Boguradzki, P.6    Dmoszynska, A.7    Kowal, M.8    Kloczko, J.9    Piszcz, J.10
  • 16
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712 (CALGB 9712)
    • DOI 10.1182/blood-2002-04-1258
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Byrd JC, Peterson BL, Morrison VA, Park K, Jacobson R, Hoke E, Vardiman JW, Rai K, Schiffer CA, Larson RA, Blood 2003 101 6 14 10.1182/blood-2002-04- 1258 12393429 (Pubitemid 36025880)
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 17
    • 79954435811 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: Long-term follow-up of CALGB study 9712
    • 10.1200/JCO.2010.31.1811 21321292
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term follow-up of CALGB study 9712. Woyach JA, Ruppert AS, Heerema NA, Peterson BL, Gribben JG, Morrison VA, Rai KR, Larson RA, Byrd JC, J Clin Oncol 2011 29 1349 1355 10.1200/JCO.2010.31.1811 21321292
    • (2011) J Clin Oncol , vol.29 , pp. 1349-1355
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3    Peterson, B.L.4    Gribben, J.G.5    Morrison, V.A.6    Rai, K.R.7    Larson, R.A.8    Byrd, J.C.9
  • 18
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • DOI 10.1182/blood-2006-07-033274
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Kay NE, Geyer SM, Call TG, Shanafelt TD, Zent CS, Jelinek DF, Tschumper R, Bone ND, Dewald GW, Lin TS, et al. Blood 2007 109 405 411 10.1182/blood-2006-07-033274 17008537 (Pubitemid 46105933)
    • (2007) Blood , vol.109 , Issue.2 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3    Shanafelt, T.D.4    Zent, C.S.5    Jelinek, D.F.6    Tschumper, R.7    Bone, N.D.8    Dewald, G.W.9    Lin, T.S.10    Heerema, N.A.11    Smith, L.12    Grever, M.R.13    Byrd, J.C.14
  • 20
    • 84864336293 scopus 로고    scopus 로고
    • A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia
    • 10.1007/s10637-011-9737-y 21922186
    • A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia. Reynolds C, Di Bella N, Lyons RM, Hyman W, Richards DA, Robbins GJ, Vellek M, Boehm KA, Zhan F, Asmar L, Invest New Drugs 2012 30 1232 1240 10.1007/s10637-011-9737-y 21922186
    • (2012) Invest New Drugs , vol.30 , pp. 1232-1240
    • Reynolds, C.1    Di Bella, N.2    Lyons, R.M.3    Hyman, W.4    Richards, D.A.5    Robbins, G.J.6    Vellek, M.7    Boehm, K.A.8    Zhan, F.9    Asmar, L.10
  • 23
    • 84859719803 scopus 로고    scopus 로고
    • Rituximab Maintenance in Patients with Chronic Lymphocytic Leukemia (CLL) after Upfront Treatment with Rituximab Plus Fludarabine, Cyclophosphamide, and Mitoxantrone (R-FCM): Final Results of a Multicenter Phase II Trial on Behalf of the Spanish CLL Study Group (GELLC)
    • Rituximab Maintenance In Patients with Chronic Lymphocytic Leukemia (CLL) After Upfront Treatment with Rituximab Plus Fludarabine, Cyclophosphamide, and Mitoxantrone (R-FCM): Final Results of a Multicenter Phase II Trial On Behalf of the Spanish CLL Study Group (GELLC). Bosch F, Abrisqueta P, Villamor N, Terol MJ, Gonzalez-Barca E, Gonzalez M, Ferra C, Abella E, Delgado J, Garcia-Marco JA, et al. ASH Annual Meeting Abstracts 2011 118 293
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 293
    • Bosch, F.1    Abrisqueta, P.2    Villamor, N.3    Terol, M.J.4    Gonzalez-Barca, E.5    Gonzalez, M.6    Ferra, C.7    Abella, E.8    Delgado, J.9    Garcia-Marco, J.A.10
  • 24
    • 84867232817 scopus 로고    scopus 로고
    • Cyclophosphamide, adriamycin, vincristine and prednisone plus rituximab (chop-r) in fludarabine (f) refractory chronic lymphocytic leukemia (cll) or cll with autoimmune cytopenia (aic) or richter's transformation (rt): final analysis of a phase ii study of the german cll study group
    • Cyclophosphamide, Adriamycin, Vincristine and Prednisone Plus Rituximab (CHOP-R) in Fludarabine (F) Refractory Chronic Lymphocytic Leukemia (CLL) or CLL with Autoimmune Cytopenia (AIC) or Richter's Transformation (RT): Final Analysis of a Phase II Study of the German CLL Study Group. Jenke P, Eichhorst B, Busch R, Anheier N, Duehrsen U, Duerig J, Dreyling MH, Bergmann M, Goebeler ME, Hurtz HJ, et al. ASH Annual Meeting Abstracts 2011 118 2860
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 2860
    • Jenke, P.1    Eichhorst, B.2    Busch, R.3    Anheier, N.4    Duehrsen, U.5    Duerig, J.6    Dreyling, M.H.7    Bergmann, M.8    Goebeler, M.E.9    Hurtz, H.J.10
  • 25
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • 10.1200/JCO.2007.12.9098 17984186
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J, Sirard C, Mayer J, J Clin Oncol 2007 25 5616 5623 10.1200/JCO.2007.12.9098 17984186
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3    Jaksic, B.4    Dmoszynska, A.5    Wu, J.6    Sirard, C.7    Mayer, J.8
  • 26
    • 84856272135 scopus 로고    scopus 로고
    • An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
    • 10.1111/j.1365-2141.2011.08965.x 22150204
    • An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients. Cortelezzi A, Gritti G, Laurenti L, Cuneo A, Ciolli S, Di Renzo N, Musto P, Mauro FR, Cascavilla N, Falchi L, et al. Br J Haematol 2012 156 481 489 10.1111/j.1365-2141.2011.08965.x 22150204
    • (2012) Br J Haematol , vol.156 , pp. 481-489
    • Cortelezzi, A.1    Gritti, G.2    Laurenti, L.3    Cuneo, A.4    Ciolli, S.5    Di Renzo, N.6    Musto, P.7    Mauro, F.R.8    Cascavilla, N.9    Falchi, L.10
  • 27
    • 84857527105 scopus 로고    scopus 로고
    • Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    • 10.3109/10428194.2011.623258 21919823
    • Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia. Gritti G, Reda G, Maura F, Piciocchi A, Baldini L, Molica S, Neri A, Cortelezzi A, Leuk Lymphoma 2012 53 424 429 10.3109/10428194.2011. 623258 21919823
    • (2012) Leuk Lymphoma , vol.53 , pp. 424-429
    • Gritti, G.1    Reda, G.2    Maura, F.3    Piciocchi, A.4    Baldini, L.5    Molica, S.6    Neri, A.7    Cortelezzi, A.8
  • 28
    • 84861343178 scopus 로고    scopus 로고
    • Alemtuzumab plus oral dexamethasone. Followed by alemtuzumab maintenance or allogeneic transplantation in ultra high-risk cll: interim analysis of a phase ii study of the gcllsg and fcgcll/mw
    • Alemtuzumab Plus Oral Dexamethasone. Followed by Alemtuzumab Maintenance or Allogeneic Transplantation in Ultra High-Risk CLL: Interim Analysis of a Phase II Study of the GCLLSG and fcgcll/MW. Stilgenbauer S, Cymbalista F, Leblond V, Delmer A, Winkler D, Buhler A, Zenz T, Mack S, Busch R, Hinke A, et al. ASH Annual Meeting Abstracts 2011 118 2854
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 2854
    • Stilgenbauer, S.1    Cymbalista, F.2    Leblond, V.3    Delmer, A.4    Winkler, D.5    Buhler, A.6    Zenz, T.7    MacK, S.8    Busch, R.9    Hinke, A.10
  • 29
    • 84861347590 scopus 로고    scopus 로고
    • Immunochemotherapy with Low-Dose Subcutaneous Alemtuzumab (A) Plus Oral Fludarabine and Cyclophosphamide (FC) Is Safe and Induces More and Deeper Complete Remissions in Untreated Patients with High-Risk Chronic Lymphocytic Leukemia (CLL) Than Chemotherapy with FC Alone. An Early Analysis of the Randomized Phase-III HOVON68 CLL Trial
    • Immunochemotherapy with Low-Dose Subcutaneous Alemtuzumab (A) Plus Oral Fludarabine and Cyclophosphamide (FC) Is Safe and Induces More and Deeper Complete Remissions in Untreated Patients with High-Risk Chronic Lymphocytic Leukemia (CLL) Than Chemotherapy with FC Alone. An Early Analysis of the Randomized Phase-III HOVON68 CLL Trial. Geisler CH, van 't Veer MM, van Putten W, Jurlander J, Walewski J, Tjonnfjord G, Itala-Remes M, Kimby E, Kozak T, Polliack A, et al. ASH Annual Meeting Abstracts 2011 118 290
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 290
    • Geisler, C.H.1    Van 'T Veer, M.M.2    Van Putten, W.3    Jurlander, J.4    Walewski, J.5    Tjonnfjord, G.6    Itala-Remes, M.7    Kimby, E.8    Kozak, T.9    Polliack, A.10
  • 30
    • 80052188111 scopus 로고    scopus 로고
    • Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia
    • 10.1182/blood-2011-03-341032 21670470
    • Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia. Badoux XC, Keating MJ, Wang X, O'Brien SM, Ferrajoli A, Faderl S, Burger J, Koller C, Lerner S, Kantarjian H, Wierda WG, Blood 2011 118 2085 2093 10.1182/blood-2011-03-341032 21670470
    • (2011) Blood , vol.118 , pp. 2085-2093
    • Badoux, X.C.1    Keating, M.J.2    Wang, X.3    O'Brien, S.M.4    Ferrajoli, A.5    Faderl, S.6    Burger, J.7    Koller, C.8    Lerner, S.9    Kantarjian, H.10    Wierda, W.G.11
  • 32
    • 84867232818 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous alemtuzumab after induction treatment with oral FC (Fludarabine and Cyclophosphamide) in Previously Untreated Patients Aged 65-70 Years with Advanced Stage Chronic Lymphocytic Leukemia (CLL): Final Results of a Phase II Study from the FCGCLL/WM
    • Consolidation Therapy with Subcutaneous Alemtuzumab After Induction Treatment with Oral FC (Fludarabine and Cyclophosphamide) in Previously Untreated Patients Aged 65-70 Years with Advanced Stage Chronic Lymphocytic Leukemia (CLL): Final Results of a Phase II Study From the FCGCLL/WM. Delmer A, Tournilhac O, Lepretre S, Cazin B, Feugier P, Dreyfus B, Mahe B, Leporrier M, Michallet A-S, Jaccard A, et al. ASH Annual Meeting Abstracts 2011 118 3900
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 3900
    • Delmer, A.1    Tournilhac, O.2    Lepretre, S.3    Cazin, B.4    Feugier, P.5    Dreyfus, B.6    Mahe, B.7    Leporrier, M.8    Michallet, A.-S.9    Jaccard, A.10
  • 33
    • 84867229641 scopus 로고    scopus 로고
    • Eradication of minimal residual disease using alemtuzumab consolidation after high-dose methyl-prednisolone plus rituximab (hdmp-r) is safe, effective and induces long term remission in chronic lymphocytic leukemia
    • Eradication of Minimal Residual Disease Using Alemtuzumab Consolidation After High-Dose Methyl-Prednisolone Plus Rituximab (HDMP-R) Is Safe, Effective and Induces Long Term Remission in Chronic Lymphocytic Leukemia. Castro JE, Ariza-Serrano LM, Barajas-Gamboa JS, Diaz-Perez JA, James DF, Ale-Ali A, Kipps TJ, ASH Annual Meeting Abstracts 2011 118 2866
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 2866
    • Castro, J.E.1    Ariza-Serrano, L.M.2    Barajas-Gamboa, J.S.3    Diaz-Perez, J.A.4    James, D.F.5    Ale-Ali, A.6    Kipps, T.J.7
  • 40
    • 34547691135 scopus 로고    scopus 로고
    • Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
    • DOI 10.1158/1078-0432.CCR-06-1463
    • Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Byrd JC, O'Brien S, Flinn IW, Kipps TJ, Weiss M, Rai K, Lin TS, Woodworth J, Wynne D, Reid J, et al. Clin Cancer Res 2007 13 4448 4455 10.1158/1078-0432.CCR-06-1463 17671129 (Pubitemid 47219713)
    • (2007) Clinical Cancer Research , vol.13 , Issue.15 , pp. 4448-4455
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.W.3    Kipps, T.J.4    Weiss, M.5    Rai, K.6    Lin, T.S.7    Woodworth, J.8    Wynne, D.9    Reid, J.10    Molina, A.11    Leigh, B.12    Harris, S.13
  • 41
    • 77449133613 scopus 로고    scopus 로고
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • 10.1182/blood-2009-08-237727 19843887
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Byrd JC, Kipps TJ, Flinn IW, Castro J, Lin TS, Wierda W, Heerema N, Woodworth J, Hughes S, Tangri S, et al. Blood 2010 115 489 495 10.1182/blood-2009-08-237727 19843887
    • (2010) Blood , vol.115 , pp. 489-495
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3    Castro, J.4    Lin, T.S.5    Wierda, W.6    Heerema, N.7    Woodworth, J.8    Hughes, S.9    Tangri, S.10
  • 42
    • 78149474940 scopus 로고    scopus 로고
    • The clinical application of monoclonal antibodies in chronic lymphocytic leukemia
    • 10.1182/blood-2010-04-001230 20610811
    • The clinical application of monoclonal antibodies in chronic lymphocytic leukemia. Jaglowski SM, Alinari L, Lapalombella R, Muthusamy N, Byrd JC, Blood 2010 116 3705 3714 10.1182/blood-2010-04-001230 20610811
    • (2010) Blood , vol.116 , pp. 3705-3714
    • Jaglowski, S.M.1    Alinari, L.2    Lapalombella, R.3    Muthusamy, N.4    Byrd, J.C.5
  • 44
    • 79953183947 scopus 로고    scopus 로고
    • Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab
    • 10.4049/jimmunol.1000303 21296976
    • Mechanism of action of type II, glycoengineered, anti-CD20 monoclonal antibody GA101 in B-chronic lymphocytic leukemia whole blood assays in comparison with rituximab and alemtuzumab. Bologna L, Gotti E, Manganini M, Rambaldi A, Intermesoli T, Introna M, Golay J, J Immunol 2011 186 3762 3769 10.4049/jimmunol.1000303 21296976
    • (2011) J Immunol , vol.186 , pp. 3762-3769
    • Bologna, L.1    Gotti, E.2    Manganini, M.3    Rambaldi, A.4    Intermesoli, T.5    Introna, M.6    Golay, J.7
  • 46
    • 80052937408 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
    • 10.1182/blood-2011-04-348896 21690557
    • Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease. Lacy MQ, Allred JB, Gertz MA, Hayman SR, Short KD, Buadi F, Dispenzieri A, Kumar S, Greipp PR, Lust JA, et al. Blood 2011 118 2970 2975 10.1182/blood-2011-04-348896 21690557
    • (2011) Blood , vol.118 , pp. 2970-2975
    • Lacy, M.Q.1    Allred, J.B.2    Gertz, M.A.3    Hayman, S.R.4    Short, K.D.5    Buadi, F.6    Dispenzieri, A.7    Kumar, S.8    Greipp, P.R.9    Lust, J.A.10
  • 48
    • 69949096727 scopus 로고    scopus 로고
    • Mechanism of action of lenalidomide in hematological malignancies
    • 10.1186/1756-8722-2-36 19674465
    • Mechanism of action of lenalidomide in hematological malignancies. Kotla V, Goel S, Nischal S, Heuck C, Vivek K, Das B, Verma A, J Hematol Oncol 2009 2 36 10.1186/1756-8722-2-36 19674465
    • (2009) J Hematol Oncol , vol.2 , pp. 36
    • Kotla, V.1    Goel, S.2    Nischal, S.3    Heuck, C.4    Vivek, K.5    Das, B.6    Verma, A.7
  • 55
    • 0029094664 scopus 로고
    • Methylprednisolone in advanced chronic lymphocytic leukaemia: Rationale for, and effectiveness of treatment suggested by DiSC assay
    • 10.1159/000204115 7543720
    • Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay. Bosanquet AG, McCann SR, Crotty GM, Mills MJ, Catovsky D, Acta Haematol 1995 93 73 79 10.1159/000204115 7543720
    • (1995) Acta Haematol , vol.93 , pp. 73-79
    • Bosanquet, A.G.1    McCann, S.R.2    Crotty, G.M.3    Mills, M.J.4    Catovsky, D.5
  • 58
    • 56249095457 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia
    • 10.1038/leu.2008.214 18754025
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Castro JE, Sandoval-Sus JD, Bole J, Rassenti L, Kipps TJ, Leukemia 2008 22 2048 2053 10.1038/leu.2008.214 18754025
    • (2008) Leukemia , vol.22 , pp. 2048-2053
    • Castro, J.E.1    Sandoval-Sus, J.D.2    Bole, J.3    Rassenti, L.4    Kipps, T.J.5
  • 59
    • 70350132633 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
    • 10.1038/leu.2009.133 19693094
    • Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. Castro JE, James DF, Sandoval-Sus JD, Jain S, Bole J, Rassenti L, Kipps TJ, Leukemia 2009 23 1779 1789 10.1038/leu.2009.133 19693094
    • (2009) Leukemia , vol.23 , pp. 1779-1789
    • Castro, J.E.1    James, D.F.2    Sandoval-Sus, J.D.3    Jain, S.4    Bole, J.5    Rassenti, L.6    Kipps, T.J.7
  • 60
    • 37149029392 scopus 로고    scopus 로고
    • Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features
    • DOI 10.1080/10428190701724801, PII 788239125
    • Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features. Bowen DA, Call TG, Jenkins GD, Zent CS, Schwager SM, Van Dyke DL, Jelinek DF, Kay NE, Shanafelt TD, Leuk Lymphoma 2007 48 2412 2417 10.1080/10428190701724801 18067017 (Pubitemid 350253473)
    • (2007) Leukemia and Lymphoma , vol.48 , Issue.12 , pp. 2412-2417
    • Bowen, D.A.1    Call, T.G.2    Jenkins, G.D.3    Zent, C.Z.4    Schwager, S.M.5    Van Dyke, D.L.6    Jelinek, D.F.7    Kay, N.E.8    Shanafelt, T.D.9
  • 61
    • 79957456534 scopus 로고    scopus 로고
    • Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia
    • 10.3109/10428194.2011.562572 21599591
    • Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia. Pileckyte R, Jurgutis M, Valceckiene V, Stoskus M, Gineikiene E, Sejoniene J, Degulys A, Zvirblis T, Griskevicius L, Leuk Lymphoma 2011 52 1055 1065 10.3109/10428194. 2011.562572 21599591
    • (2011) Leuk Lymphoma , vol.52 , pp. 1055-1065
    • Pileckyte, R.1    Jurgutis, M.2    Valceckiene, V.3    Stoskus, M.4    Gineikiene, E.5    Sejoniene, J.6    Degulys, A.7    Zvirblis, T.8    Griskevicius, L.9
  • 62
    • 83255170348 scopus 로고    scopus 로고
    • Ofatumumab and High-Dose Methylprednisolone Is An Effective Salvage Treatment for Heavily Pretreated, Unfit or Refractory Patients with Chronic Lymphocytic Leukemia: Single Institution Experience
    • Ofatumumab and High-Dose Methylprednisolone Is An Effective Salvage Treatment for Heavily Pretreated, Unfit or Refractory Patients with Chronic Lymphocytic Leukemia: Single Institution Experience. Castro JE, Barajas-Gamboa JS, Melo-Cardenas J, Paz RN, Bernal-Corzo C, Ale-Ali A, James DF, Kipps TJ, ASH Annual Meeting Abstracts 2010 116 4638
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 4638
    • Castro, J.E.1    Barajas-Gamboa, J.S.2    Melo-Cardenas, J.3    Paz, R.N.4    Bernal-Corzo, C.5    Ale-Ali, A.6    James, D.F.7    Kipps, T.J.8
  • 63
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
    • 10.1200/JCO.2009.22.6944 19826119
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. Lin TS, Ruppert AS, Johnson AJ, Fischer B, Heerema NA, Andritsos LA, Blum KA, Flynn JM, Jones JA, Hu W, et al. J Clin Oncol 2009 27 6012 6018 10.1200/JCO.2009.22.6944 19826119
    • (2009) J Clin Oncol , vol.27 , pp. 6012-6018
    • Lin, T.S.1    Ruppert, A.S.2    Johnson, A.J.3    Fischer, B.4    Heerema, N.A.5    Andritsos, L.A.6    Blum, K.A.7    Flynn, J.M.8    Jones, J.A.9    Hu, W.10
  • 65
    • 83255171691 scopus 로고    scopus 로고
    • Response, Progression-Free Survival, and Overall Survival of Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Flavopiridol: Impact of Poor Risk Cytogenetic Abnormalities
    • Response, Progression-Free Survival, and Overall Survival of Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Flavopiridol: Impact of Poor Risk Cytogenetic Abnormalities. Woyach JA, Ruppert AS, Blum KA, Jones JA, Flynn JM, Johnson AJ, Grever MR, Byrd JC, Heerema NA, ASH Annual Meeting Abstracts 2010 116 2456
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 2456
    • Woyach, J.A.1    Ruppert, A.S.2    Blum, K.A.3    Jones, J.A.4    Flynn, J.M.5    Johnson, A.J.6    Grever, M.R.7    Byrd, J.C.8    Heerema, N.A.9
  • 66
    • 84863393289 scopus 로고    scopus 로고
    • Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach
    • 10.3324/haematol.2011.047324 22271900
    • Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach. Stephens DM, Ruppert AS, Blum K, Jones J, Flynn JM, Johnson AJ, Ji J, Phelps MA, Grever MR, Byrd JC, Haematologica 2012 97 423 427 10.3324/haematol.2011.047324 22271900
    • (2012) Haematologica , vol.97 , pp. 423-427
    • Stephens, D.M.1    Ruppert, A.S.2    Blum, K.3    Jones, J.4    Flynn, J.M.5    Johnson, A.J.6    Ji, J.7    Phelps, M.A.8    Grever, M.R.9    Byrd, J.C.10
  • 68
    • 79955757849 scopus 로고    scopus 로고
    • Update on the Phase i Study of the Cyclin Dependent Kinase Inhibitor Dinaciclib (SCH 727965) in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL): Confirmation of Clinical Activity and Feasibility of Long-Term Administration
    • Update on the Phase I Study of the Cyclin Dependent Kinase Inhibitor Dinaciclib (SCH 727965) In Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL): Confirmation of Clinical Activity and Feasibility of Long-Term Administration. Flynn JM, Jones JA, Andritsos L, Blum KA, Johnson AJ, Hessler J, Wiley E, Poon J, Small K, Statkevich P, et al. ASH Annual Meeting Abstracts 2010 116 1396
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 1396
    • Flynn, J.M.1    Jones, J.A.2    Andritsos, L.3    Blum, K.A.4    Johnson, A.J.5    Hessler, J.6    Wiley, E.7    Poon, J.8    Small, K.9    Statkevich, P.10
  • 69
    • 78649487988 scopus 로고    scopus 로고
    • An Ongoing Phase 1/2a Study of ABT-263; Pharmacokinetics (PK), Safety and Anti-Tumor Activity in Patients (pts) with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
    • An Ongoing Phase 1/2a Study of ABT-263; Pharmacokinetics (PK), Safety and Anti-Tumor Activity in Patients (pts) with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). Roberts AW, Seymour JF, Brown JR, Wierda WG, Kipps TJ, Carney D, Xiong H, Cui Y, Busman T, Enschede S, et al. ASH Annual Meeting Abstracts 2009 114 883
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 883
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3    Wierda, W.G.4    Kipps, T.J.5    Carney, D.6    Xiong, H.7    Cui, Y.8    Busman, T.9    Enschede, S.10
  • 70
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
    • 10.1200/JCO.2011.34.7898 22184378
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. Roberts AW, Seymour JF, Brown JR, Wierda WG, Kipps TJ, Khaw SL, Carney DA, He SZ, Huang DC, Xiong H, et al. J Clin Oncol 2012 30 488 496 10.1200/JCO.2011.34.7898 22184378
    • (2012) J Clin Oncol , vol.30 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3    Wierda, W.G.4    Kipps, T.J.5    Khaw, S.L.6    Carney, D.A.7    He, S.Z.8    Huang, D.C.9    Xiong, H.10
  • 72
    • 70449723145 scopus 로고    scopus 로고
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
    • 10.1200/JCO.2009.22.5748 19738118
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. O'Brien S, Moore JO, Boyd TE, Larratt LM, Skotnicki AB, Koziner B, Chanan-Khan AA, Seymour JF, Gribben J, Itri LM, Rai KR, J Clin Oncol 2009 27 5208 5212 10.1200/JCO.2009.22.5748 19738118
    • (2009) J Clin Oncol , vol.27 , pp. 5208-5212
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3    Larratt, L.M.4    Skotnicki, A.B.5    Koziner, B.6    Chanan-Khan, A.A.7    Seymour, J.F.8    Gribben, J.9    Itri, L.M.10    Rai, K.R.11
  • 73
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • 10.1182/blood-2008-02-138560 18836097
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Balakrishnan K, Burger JA, Wierda WG, Gandhi V, Blood 2009 113 149 153 10.1182/blood-2008-02-138560 18836097
    • (2009) Blood , vol.113 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3    Gandhi, V.4
  • 74
    • 58849164097 scopus 로고    scopus 로고
    • Phase i study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • 18931344
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. O'Brien SM, Claxton DF, Crump M, Faderl S, Kipps T, Keating MJ, Viallet J, Cheson BD, Blood 2009 113 299 305 18931344
    • (2009) Blood , vol.113 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3    Faderl, S.4    Kipps, T.5    Keating, M.J.6    Viallet, J.7    Cheson, B.D.8
  • 75
    • 79954438975 scopus 로고    scopus 로고
    • The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia
    • 10.1038/leu.2010.322 21358717
    • The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia. Durig J, Duhrsen U, Klein-Hitpass L, Worm J, Hansen JB, Orum H, Wissenbach M, Leukemia 2011 25 638 647 10.1038/leu.2010.322 21358717
    • (2011) Leukemia , vol.25 , pp. 638-647
    • Durig, J.1    Duhrsen, U.2    Klein-Hitpass, L.3    Worm, J.4    Hansen, J.B.5    Orum, H.6    Wissenbach, M.7
  • 76
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • 10.1182/blood-2011-05-352492 21803855
    • The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Hoellenriegel J, Meadows SA, Sivina M, Wierda WG, Kantarjian H, Keating MJ, Giese N, O'Brien S, Yu A, Miller LL, et al. Blood 2011 118 3603 3612 10.1182/blood-2011-05-352492 21803855
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3    Wierda, W.G.4    Kantarjian, H.5    Keating, M.J.6    Giese, N.7    O'Brien, S.8    Yu, A.9    Miller, L.L.10
  • 77
    • 79953655788 scopus 로고    scopus 로고
    • CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110{delta}, Demonstrates Clinical Activity and Pharmacodynamic Effects in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia
    • CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110{delta}, Demonstrates Clinical Activity and Pharmacodynamic Effects In Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia. Furman RR, Byrd JC, Brown JR, Coutre SE, Benson DM, Wagner-Johnston ND, Flinn IW, Kahl BS, Spurgeon SE, Lannutti B, et al. ASH Annual Meeting Abstracts 2010 116 55
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 55
    • Furman, R.R.1    Byrd, J.C.2    Brown, J.R.3    Coutre, S.E.4    Benson, D.M.5    Wagner-Johnston, N.D.6    Flinn, I.W.7    Kahl, B.S.8    Spurgeon, S.E.9    Lannutti, B.10
  • 78
    • 84861344593 scopus 로고    scopus 로고
    • A Phase 1 Study of the Selective Phosphatidylinositol 3-Kinase-Delta (PI3K{delta}) Inhibitor, CAL-101 (GS-1101), in Combination with Rituximab and/or Bendamustine in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
    • A Phase 1 Study of the Selective Phosphatidylinositol 3-Kinase-Delta (PI3K{delta}) Inhibitor, CAL-101 (GS-1101), in Combination with Rituximab and/or Bendamustine in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). Sharman J, de Vos S, Leonard JP, Furman RR, Coutre SE, Flinn IW, Schreeder MT, Barrientos JC, Wagner-Johnston ND, Boyd T, et al. ASH Annual Meeting Abstracts 2011 118 1787
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 1787
    • Sharman, J.1    De Vos, S.2    Leonard, J.P.3    Furman, R.R.4    Coutre, S.E.5    Flinn, I.W.6    Schreeder, M.T.7    Barrientos, J.C.8    Wagner-Johnston, N.D.9    Boyd, T.10
  • 80
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • 10.1182/blood-2011-11-390989 22279054
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. de Rooij MF, Kuil A, Geest CR, Eldering E, Chang BY, Buggy JJ, Pals ST, Spaargaren M, Blood 2012 119 2590 2594 10.1182/blood-2011-11-390989 22279054
    • (2012) Blood , vol.119 , pp. 2590-2594
    • De Rooij, M.F.1    Kuil, A.2    Geest, C.R.3    Eldering, E.4    Chang, B.Y.5    Buggy, J.J.6    Pals, S.T.7    Spaargaren, M.8
  • 81
    • 84555223808 scopus 로고    scopus 로고
    • Activity and tolerability of the Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): Interim results of a phase Ib/II study
    • Activity and tolerability of the Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): Interim results of a phase Ib/II study. Byrd JC, Blum KA, Burger JA, Coutre SE, Sharman JP, Furman RR, Flinn IW, Grant BW, Richards DA, Zhao W, et al. ASCO Meeting Abstracts 2011 29 6508
    • (2011) ASCO Meeting Abstracts , vol.29 , pp. 6508
    • Byrd, J.C.1    Blum, K.A.2    Burger, J.A.3    Coutre, S.E.4    Sharman, J.P.5    Furman, R.R.6    Flinn, I.W.7    Grant, B.W.8    Richards, D.A.9    Zhao, W.10
  • 82
    • 84861345119 scopus 로고    scopus 로고
    • The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Induces Durable Responses in Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Follow-up of a Phase Ib/II Study
    • The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Induces Durable Responses in Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Follow-up of a Phase Ib/II Study. O'Brien S, Burger JA, Blum KA, Furman RR, Coutre SE, Sharman J, Flinn IW, Grant B, Heerema NA, Johnson AJ, et al. ASH Annual Meeting Abstracts 2011 118 983
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 983
    • O'Brien, S.1    Burger, J.A.2    Blum, K.A.3    Furman, R.R.4    Coutre, S.E.5    Sharman, J.6    Flinn, I.W.7    Grant, B.8    Heerema, N.A.9    Johnson, A.J.10
  • 83
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • 10.1182/blood-2009-08-236471 19965662
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, Schaefer-Cutillo J, De Vos S, Sinha R, Leonard JP, et al. Blood 2010 115 2578 2585 10.1182/blood-2009-08-236471 19965662
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3    Johnston, P.B.4    Vose, J.M.5    Lacasce, A.6    Schaefer-Cutillo, J.7    De Vos, S.8    Sinha, R.9    Leonard, J.P.10
  • 84
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • 10.1182/blood-2009-03-212837 19491390
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, Wierda WG, Gandhi V, Burger JA, Blood 2009 114 1029 1037 10.1182/blood-2009-03-212837 19491390
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3    Sivina, M.4    Keating, M.J.5    Wierda, W.G.6    Gandhi, V.7    Burger, J.A.8
  • 89
    • 79551631475 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in chronic lymphocytic leukemia: Results of European intergroup randomized trial comparing autografting versus observation
    • 10.1182/blood-2010-09-308775 21106985
    • Autologous hematopoietic stem cell transplantation in chronic lymphocytic leukemia: results of European intergroup randomized trial comparing autografting versus observation. Michallet M, Dreger P, Sutton L, Brand R, Richards S, van Os M, Sobh M, Choquet S, Corront B, Dearden C, et al. Blood 2011 117 1516 1521 10.1182/blood-2010-09-308775 21106985
    • (2011) Blood , vol.117 , pp. 1516-1521
    • Michallet, M.1    Dreger, P.2    Sutton, L.3    Brand, R.4    Richards, S.5    Van Os, M.6    Sobh, M.7    Choquet, S.8    Corront, B.9    Dearden, C.10
  • 90
    • 84861498523 scopus 로고    scopus 로고
    • Early autologous stem cell transplantation for chronic lymphocytic leukemia: Long-term follow-up of the German CLL Study Group CLL3 trial
    • 10.1182/blood-2011-09-378505 22490331
    • Early autologous stem cell transplantation for chronic lymphocytic leukemia: long-term follow-up of the German CLL Study Group CLL3 trial. Dreger P, Dohner H, McClanahan F, Busch R, Ritgen M, Greinix H, Fink AM, Knauf W, Stadler M, Pfreundschuh M, et al. Blood 2012 119 4851 4859 10.1182/blood-2011- 09-378505 22490331
    • (2012) Blood , vol.119 , pp. 4851-4859
    • Dreger, P.1    Dohner, H.2    McClanahan, F.3    Busch, R.4    Ritgen, M.5    Greinix, H.6    Fink, A.M.7    Knauf, W.8    Stadler, M.9    Pfreundschuh, M.10
  • 91
    • 27744549869 scopus 로고    scopus 로고
    • Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-)
    • DOI 10.1158/1078-0432.CCR-05-0941
    • Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-). Caballero D, Garcia-Marco JA, Martino R, Mateos V, Ribera JM, Sarra J, Leon A, Sanz G, de la Serna J, Cabrera R, et al. Clin Cancer Res 2005 11 7757 7763 10.1158/1078-0432.CCR-05-0941 16278397 (Pubitemid 41611619)
    • (2005) Clinical Cancer Research , vol.11 , Issue.21 , pp. 7757-7763
    • Caballero, D.1    Garcia-Marco, J.A.2    Martino, R.3    Mateos, V.4    Ribera, J.M.5    Sarra, J.6    Leon, A.7    Sanz, G.8    De La Serna, J.9    Cabrera, R.10    Gonzalez, M.11    Sierra, J.12    San Miguel, J.13
  • 92
  • 93
    • 24944487676 scopus 로고    scopus 로고
    • Unrelated donor marrow transplantation for B-cell chronic lymphocytic leukemia after using myeloablative conditioning: Results from the Center for International Blood and Marrow Transplant research
    • 10.1200/JCO.2005.03.962 16043827
    • Unrelated donor marrow transplantation for B-cell chronic lymphocytic leukemia after using myeloablative conditioning: results from the Center for International Blood and Marrow Transplant research. Pavletic SZ, Khouri IF, Haagenson M, King RJ, Bierman PJ, Bishop MR, Carston M, Giralt S, Molina A, Copelan EA, et al. J Clin Oncol 2005 23 5788 5794 10.1200/JCO.2005.03.962 16043827
    • (2005) J Clin Oncol , vol.23 , pp. 5788-5794
    • Pavletic, S.Z.1    Khouri, I.F.2    Haagenson, M.3    King, R.J.4    Bierman, P.J.5    Bishop, M.R.6    Carston, M.7    Giralt, S.8    Molina, A.9    Copelan, E.A.10
  • 96
    • 70350475037 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: Ready for prime time?
    • 10.1182/blood-2009-05-206821 19641189
    • Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time? Delgado J, Milligan DW, Dreger P, Blood 2009 114 2581 2588 10.1182/blood-2009-05-206821 19641189
    • (2009) Blood , vol.114 , pp. 2581-2588
    • Delgado, J.1    Milligan, D.W.2    Dreger, P.3
  • 97
    • 83255164801 scopus 로고    scopus 로고
    • Hematopoietic stem cell allografting for chronic lymphocytic leukemia: A focus on reduced-intensity conditioning regimens
    • Hematopoietic stem cell allografting for chronic lymphocytic leukemia: a focus on reduced-intensity conditioning regimens. Kharfan-Dabaja MA, Bazarbachi A, Cancer control: journal of the Moffitt Cancer Center 2012 19 68 75
    • (2012) Cancer Control: Journal of the Moffitt Cancer Center , vol.19 , pp. 68-75
    • Kharfan-Dabaja, M.A.1    Bazarbachi, A.2
  • 99
    • 63849169216 scopus 로고    scopus 로고
    • Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
    • 19330725
    • Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Milani C, Castillo J, Curr Opin Mol Ther 2009 11 200 207 19330725
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 200-207
    • Milani, C.1    Castillo, J.2
  • 101
    • 79955819069 scopus 로고    scopus 로고
    • The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-kappaB/Snail/RKIP/PTEN resistance loop in B-NHL cells: Role in sensitization to TRAIL apoptosis
    • 21455568
    • The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-kappaB/Snail/RKIP/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis. Baritaki S, Militello L, Malaponte G, Spandidos DA, Salcedo M, Bonavida B, Int J Oncol 2011 38 1683 1694 21455568
    • (2011) Int J Oncol , vol.38 , pp. 1683-1694
    • Baritaki, S.1    Militello, L.2    Malaponte, G.3    Spandidos, D.A.4    Salcedo, M.5    Bonavida, B.6
  • 103
    • 71249091846 scopus 로고    scopus 로고
    • TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies
    • 19943209
    • TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Robak T, Robak P, Smolewski P, Curr Opin Investig Drugs 2009 10 1383 1390 19943209
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1383-1390
    • Robak, T.1    Robak, P.2    Smolewski, P.3
  • 104
    • 76349120845 scopus 로고    scopus 로고
    • A phase i study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • 10.3109/10428190903440946 20038235
    • A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Furman RR, Forero-Torres A, Shustov A, Drachman JG, Leuk Lymphoma 2010 51 228 235 10.3109/10428190903440946 20038235
    • (2010) Leuk Lymphoma , vol.51 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3    Drachman, J.G.4
  • 106
    • 84862751349 scopus 로고    scopus 로고
    • The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: A potential treatment strategy for fludarabine refractory disease
    • 10.3109/10428194.2011.647310 22149137
    • The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease. Best OG, Che Y, Singh N, Forsyth C, Christopherson RI, Mulligan SP, Leuk Lymphoma 2012 53 1367 1375 10.3109/10428194.2011.647310 22149137
    • (2012) Leuk Lymphoma , vol.53 , pp. 1367-1375
    • Best, O.G.1    Che, Y.2    Singh, N.3    Forsyth, C.4    Christopherson, R.I.5    Mulligan, S.P.6
  • 107
    • 77955870224 scopus 로고    scopus 로고
    • 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: Clinical implications of HSP90 inhibition
    • 10.1182/blood-2010-01-263756 20351313
    • 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Hertlein E, Wagner AJ, Jones J, Lin TS, Maddocks KJ, Towns WH 3rd, Goettl VM, Zhang X, Jarjoura D, Raymond CA, et al. Blood 2010 116 45 53 10.1182/blood-2010-01-263756 20351313
    • (2010) Blood , vol.116 , pp. 45-53
    • Hertlein, E.1    Wagner, A.J.2    Jones, J.3    Lin, T.S.4    Maddocks, K.J.5    Towns III, W.H.6    Goettl, V.M.7    Zhang, X.8    Jarjoura, D.9    Raymond, C.A.10
  • 108
    • 77649171884 scopus 로고    scopus 로고
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
    • 10.1186/1756-8722-3-5 20132536
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. Tan J, Cang S, Ma Y, Petrillo RL, Liu D, J Hematol Oncol 2010 3 5 10.1186/1756-8722-3-5 20132536
    • (2010) J Hematol Oncol , vol.3 , pp. 5
    • Tan, J.1    Cang, S.2    Ma, Y.3    Petrillo, R.L.4    Liu, D.5
  • 109
    • 84862908172 scopus 로고    scopus 로고
    • Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia
    • 10.3109/10428194.2011.610012 21827374
    • Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia. Lanasa MC, Davis PH, Datto M, Li Z, Gockerman JP, Moore JO, Decastro CM, Friedman DR, Diehl LF, Rehder C, et al. Leuk Lymphoma 2012 53 218 224 10.3109/10428194.2011.610012 21827374
    • (2012) Leuk Lymphoma , vol.53 , pp. 218-224
    • Lanasa, M.C.1    Davis, P.H.2    Datto, M.3    Li, Z.4    Gockerman, J.P.5    Moore, J.O.6    Decastro, C.M.7    Friedman, D.R.8    Diehl, L.F.9    Rehder, C.10
  • 110
    • 79954601408 scopus 로고    scopus 로고
    • Novel targeted therapeutics: Inhibitors of MDM2. ALK and PARP
    • 10.1186/1756-8722-4-16 22983591
    • Novel targeted therapeutics: inhibitors of MDM2. ALK and PARP. Yuan Y, Liao YM, Hsueh CT, Mirshahidi HR, Journal of hematology & oncology 2011 4 16 10.1186/1756-8722-4-16 22983591
    • (2011) Journal of Hematology & Oncology , vol.4 , pp. 16
    • Yuan, Y.1    Liao, Y.M.2    Hsueh, C.T.3    Mirshahidi, H.R.4
  • 111
    • 59049091983 scopus 로고    scopus 로고
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
    • 10.1007/s00277-008-0582-9 18704419
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Decker T, Sandherr M, Goetze K, Oelsner M, Ringshausen I, Peschel C, Ann Hematol 2009 88 221 227 10.1007/s00277-008- 0582-9 18704419
    • (2009) Ann Hematol , vol.88 , pp. 221-227
    • Decker, T.1    Sandherr, M.2    Goetze, K.3    Oelsner, M.4    Ringshausen, I.5    Peschel, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.