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Volumn 51, Issue 10, 2012, Pages 826-831

PPP2R1A mutations are common in the serous type of endometrial cancer

Author keywords

Carcinosarcoma; Endometrial cancer; PPP2R1A; Uterine serous carcinoma

Indexed keywords

ARTICLE; CARCINOSARCOMA; CLEAR CELL CARCINOMA; CONTROLLED STUDY; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; FEMALE; GENE; GENE MUTATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PPP2R1A GENE; PRIORITY JOURNAL; UNDIFFERENTIATED CARCINOMA; UTERUS CARCINOMA;

EID: 84866161747     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20850     Document Type: Article
Times cited : (40)

References (44)
  • 1
    • 0003964363 scopus 로고    scopus 로고
    • American Cancer Society. Atlanta, GA: The Society
    • American Cancer Society. Cancer facts & figures. Atlanta, GA: The Society; 2010. p. v.
    • (2010) Cancer facts & figures
  • 3
    • 0028867644 scopus 로고
    • Molecular basis of endometrial cancer
    • Berchuck A, Boyd J. Molecular basis of endometrial cancer. Cancer 1995; 76: 2034-2040.
    • (1995) Cancer , vol.76 , pp. 2034-2040
    • Berchuck, A.1    Boyd, J.2
  • 4
    • 0842267344 scopus 로고    scopus 로고
    • Gene expression profiling of tamoxifen-associated uterine cancers: Evidence for two molecular classes of endometrial carcinoma
    • Ferguson SE, Olshen AB, Viale A, Awtrey CS, Barakat RR, Boyd J. Gene expression profiling of tamoxifen-associated uterine cancers: Evidence for two molecular classes of endometrial carcinoma. Gynecol Oncol 2004; 92: 719-725.
    • (2004) Gynecol Oncol , vol.92 , pp. 719-725
    • Ferguson, S.E.1    Olshen, A.B.2    Viale, A.3    Awtrey, C.S.4    Barakat, R.R.5    Boyd, J.6
  • 5
    • 16844387095 scopus 로고    scopus 로고
    • Stratification of intermediate-risk endometrial cancer patients into groups at high risk or low risk for recurrence based on tumor gene expression profiles
    • Ferguson SE, Olshen AB, Viale A, Barakat RR, Boyd J. Stratification of intermediate-risk endometrial cancer patients into groups at high risk or low risk for recurrence based on tumor gene expression profiles. Clin Cancer Res 2005; 11: 2252-2257.
    • (2005) Clin Cancer Res , vol.11 , pp. 2252-2257
    • Ferguson, S.E.1    Olshen, A.B.2    Viale, A.3    Barakat, R.R.4    Boyd, J.5
  • 6
    • 20344383528 scopus 로고    scopus 로고
    • Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer
    • Maxwell GL, Chandramouli GV, Dainty L, et al. Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer. Clin Cancer Res 2005; 11: 4056-4066.
    • (2005) Clin Cancer Res , vol.11 , pp. 4056-4066
    • Maxwell, G.L.1    Chandramouli, G.V.2    Dainty, L.3
  • 7
    • 0037226389 scopus 로고    scopus 로고
    • Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer
    • Risinger JI, Maxwell GL, Chandramouli GV, et al. Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. Cancer Res 2003; 63: 6-11.
    • (2003) Cancer Res , vol.63 , pp. 6-11
    • Risinger, J.I.1    Maxwell, G.L.2    Chandramouli, G.V.3
  • 10
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997; 57: 3935-3940.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 12
    • 33750698981 scopus 로고    scopus 로고
    • PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
    • Hayes MP, Wang H, Espinal-Witter R, et al. PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res 2006; 12: 5932-5935.
    • (2006) Clin Cancer Res , vol.12 , pp. 5932-5935
    • Hayes, M.P.1    Wang, H.2    Espinal-Witter, R.3
  • 15
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005; 65: 10669-10673.
    • (2005) Cancer Res , vol.65 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 16
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • Pollock PM, Gartside MG, Dejeza LC, et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007; 26: 7158-7162.
    • (2007) Oncogene , vol.26 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3
  • 17
    • 0026504107 scopus 로고
    • Overexpression and mutation of p53 in endometrial carcinoma
    • Kohler MF, Berchuck A, Davidoff AM, et al. Overexpression and mutation of p53 in endometrial carcinoma. Cancer Res 1992; 52: 1622-1627.
    • (1992) Cancer Res , vol.52 , pp. 1622-1627
    • Kohler, M.F.1    Berchuck, A.2    Davidoff, A.M.3
  • 19
    • 0025986676 scopus 로고
    • Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus
    • Okamoto A, Sameshima Y, Yamada Y, et al. Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus. Cancer Res 1991; 51: 5632-5635.
    • (1991) Cancer Res , vol.51 , pp. 5632-5635
    • Okamoto, A.1    Sameshima, Y.2    Yamada, Y.3
  • 21
    • 0029967895 scopus 로고    scopus 로고
    • p53 overexpression in advanced-stage endometrial adenocarcinoma
    • Kohler MF, Carney P, Dodge R, et al. p53 overexpression in advanced-stage endometrial adenocarcinoma. Am J Obstet Gynecol 1996; 175: 1246-1252.
    • (1996) Am J Obstet Gynecol , vol.175 , pp. 1246-1252
    • Kohler, M.F.1    Carney, P.2    Dodge, R.3
  • 22
    • 0028198563 scopus 로고
    • Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer
    • Lukes AS, Kohler MF, Pieper CF, et al. Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer 1994; 73: 2380-2385.
    • (1994) Cancer , vol.73 , pp. 2380-2385
    • Lukes, A.S.1    Kohler, M.F.2    Pieper, C.F.3
  • 23
    • 78650215830 scopus 로고    scopus 로고
    • Pathologic and molecular features of uterine carcinosarcomas
    • Lopez-Garcia MA, Palacios J. Pathologic and molecular features of uterine carcinosarcomas. Semin Diagn Pathol 2010; 27: 274-286.
    • (2010) Semin Diagn Pathol , vol.27 , pp. 274-286
    • Lopez-Garcia, M.A.1    Palacios, J.2
  • 24
    • 61449477498 scopus 로고    scopus 로고
    • Non-endometrioid adenocarcinoma of the uterine corpus: A review of selected histological subtypes
    • Mendivil A, Schuler KM, Gehrig PA. Non-endometrioid adenocarcinoma of the uterine corpus: A review of selected histological subtypes. Cancer Control 2009; 16: 46-52.
    • (2009) Cancer Control , vol.16 , pp. 46-52
    • Mendivil, A.1    Schuler, K.M.2    Gehrig, P.A.3
  • 25
    • 4644222599 scopus 로고    scopus 로고
    • Distinctive gene expression profiles by cDNA microarrays in endometrioid and serous carcinomas of the endometrium
    • Cao QJ, Belbin T, Socci N, et al. Distinctive gene expression profiles by cDNA microarrays in endometrioid and serous carcinomas of the endometrium. Int J Gynecol Pathol 2004; 23: 321-329.
    • (2004) Int J Gynecol Pathol , vol.23 , pp. 321-329
    • Cao, Q.J.1    Belbin, T.2    Socci, N.3
  • 26
    • 0141619357 scopus 로고    scopus 로고
    • Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas
    • Moreno-Bueno G, Sanchez-Estevez C, Cassia R, et al. Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res 2003; 63: 5697-5702.
    • (2003) Cancer Res , vol.63 , pp. 5697-5702
    • Moreno-Bueno, G.1    Sanchez-Estevez, C.2    Cassia, R.3
  • 27
    • 77949277517 scopus 로고    scopus 로고
    • FGFR2 mutations are rare across histologic subtypes of ovarian cancer
    • Byron SA, Gartside MG, Wellens CL, et al. FGFR2 mutations are rare across histologic subtypes of ovarian cancer. Gynecol Oncol 2010; 117: 125-129.
    • (2010) Gynecol Oncol , vol.117 , pp. 125-129
    • Byron, S.A.1    Gartside, M.G.2    Wellens, C.L.3
  • 28
    • 79953666737 scopus 로고    scopus 로고
    • Somatic mutations of PPP2R1A in ovarian and uterine carcinomas
    • Shih Ie M, Panuganti PK, Kuo KT, et al. Somatic mutations of PPP2R1A in ovarian and uterine carcinomas. Am J Pathol 2011; 178: 1442-1447.
    • (2011) Am J Pathol , vol.178 , pp. 1442-1447
    • Shih Ie, M.1    Panuganti, P.K.2    Kuo, K.T.3
  • 29
    • 79952568603 scopus 로고    scopus 로고
    • Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas
    • McConechy MK, Anglesio MS, Kalloger SE, et al. Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas. J Pathol 2011; 223: 567-573.
    • (2011) J Pathol , vol.223 , pp. 567-573
    • McConechy, M.K.1    Anglesio, M.S.2    Kalloger, S.E.3
  • 30
    • 77957731999 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
    • Jones S, Wang TL, Shih Ie M, et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 2010; 330: 228-231.
    • (2010) Science , vol.330 , pp. 228-231
    • Jones, S.1    Wang, T.L.2    Shih Ie, M.3
  • 31
    • 70350340056 scopus 로고    scopus 로고
    • Serine/threonine phosphatases: Mechanism through structure
    • Shi Y. Serine/threonine phosphatases: Mechanism through structure. Cell 2009; 139: 468-484.
    • (2009) Cell , vol.139 , pp. 468-484
    • Shi, Y.1
  • 33
    • 34447106751 scopus 로고    scopus 로고
    • PP2A: Unveiling a reluctant tumor suppressor
    • Mumby M. PP2A: Unveiling a reluctant tumor suppressor. Cell 2007; 130: 21-24.
    • (2007) Cell , vol.130 , pp. 21-24
    • Mumby, M.1
  • 34
    • 66549085133 scopus 로고    scopus 로고
    • The role of PP2A A subunits in tumor suppression
    • Sablina AA, Hahn WC. The role of PP2A A subunits in tumor suppression. Cell Adh Migr 2007; 1: 140-141.
    • (2007) Cell Adh Migr , vol.1 , pp. 140-141
    • Sablina, A.A.1    Hahn, W.C.2
  • 35
    • 33947528693 scopus 로고    scopus 로고
    • The 3D structure of protein phosphatase 2A: New insights into a ubiquitous regulator of cell signaling
    • Mumby M. The 3D structure of protein phosphatase 2A: New insights into a ubiquitous regulator of cell signaling. ACS Chem Biol 2007; 2: 99-103.
    • (2007) ACS Chem Biol , vol.2 , pp. 99-103
    • Mumby, M.1
  • 37
    • 33846118688 scopus 로고    scopus 로고
    • Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
    • Cho US, Xu W. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature 2007; 445: 53-57.
    • (2007) Nature , vol.445 , pp. 53-57
    • Cho, U.S.1    Xu, W.2
  • 38
    • 33845404441 scopus 로고    scopus 로고
    • Structure of the protein phosphatase 2A holoenzyme
    • Xu Y, Xing Y, Chen Y, et al. Structure of the protein phosphatase 2A holoenzyme. Cell 2006; 127: 1239-1251.
    • (2006) Cell , vol.127 , pp. 1239-1251
    • Xu, Y.1    Xing, Y.2    Chen, Y.3
  • 39
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 2008; 14: 152-160.
    • (2008) Trends Mol Med , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 40
    • 43049121301 scopus 로고    scopus 로고
    • A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins
    • Arnold HK, Sears RC. A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev 2008; 27: 147-158.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 147-158
    • Arnold, H.K.1    Sears, R.C.2
  • 41
    • 0034708257 scopus 로고    scopus 로고
    • Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
    • Calin GA, di Iasio MG, Caprini E, et al. Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene 2000; 19: 1191-1195.
    • (2000) Oncogene , vol.19 , pp. 1191-1195
    • Calin, G.A.1    di Iasio, M.G.2    Caprini, E.3
  • 42
    • 34248384824 scopus 로고    scopus 로고
    • Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma
    • Dainty LA, Risinger JI, Morrison C, et al. Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma. Gynecol Oncol 2007; 105: 563-570.
    • (2007) Gynecol Oncol , vol.105 , pp. 563-570
    • Dainty, L.A.1    Risinger, J.I.2    Morrison, C.3
  • 43
    • 34648832104 scopus 로고    scopus 로고
    • Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas
    • Allard JE, Risinger JI, Morrison C, et al. Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas. Gynecol Oncol 2007; 107: 52-57.
    • (2007) Gynecol Oncol , vol.107 , pp. 52-57
    • Allard, J.E.1    Risinger, J.I.2    Morrison, C.3
  • 44
    • 79953773857 scopus 로고    scopus 로고
    • Mutation of PPP2R1A: A new clue in unveiling the pathogenesis of uterine serous carcinoma
    • Shih Ie M, Wang TL. Mutation of PPP2R1A: A new clue in unveiling the pathogenesis of uterine serous carcinoma. J Pathol 2011; 224: 1-4.
    • (2011) J Pathol , vol.224 , pp. 1-4
    • Shih Ie, M.1    Wang, T.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.