Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction

Cardiology Journal

Volumn 17, Issue 6, 2010, Pages 612-618

  Orozco Gutiérrez, Juan José ^a   Castillo Martínez, Lilia ^a   Orea Tejeda, Arturo ^a   Vázquez Díaz, Oscar ^a   Valdespino Trejo, Adrián ^a   Narváez David, René ^a   Keirns Davis, Candace ^b   Carrasco Ortiz, Olín ^a   Navarro Navarro, Adolfo ^a   Sánchez Santillán, Rocío ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Blood pressure; Citrulline; Heart failure; L arginine; Right ventricle

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; ANGIOTENSIN II ANTAGONIST; ARGININE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CITRULLINE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; LOOP DIURETIC AGENT; NITRATE; SPIRONOLACTONE; THIAZIDE DIURETIC AGENT;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DYSLIPIDEMIA; ECHOCARDIOGRAPHY; FEMALE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART RATE; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE FUNCTION; HUMAN; HYPERTENSION; HYPOTHYROIDISM; ISCHEMIC HEART DISEASE; LUNG ARTERY PRESSURE; MALE; OBESITY; PULMONARY HYPERTENSION; RADIOISOTOPE VENTRICULOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TREADMILL;

ADMINISTRATION, ORAL; AGED; ARGININE; BLOOD PRESSURE; CHI-SQUARE DISTRIBUTION; CITRULLINE; DIETARY SUPPLEMENTS; ECHOCARDIOGRAPHY, DOPPLER; EXERCISE TEST; FEMALE; HEART FAILURE; HUMANS; MALE; MEXICO; MIDDLE AGED; PULMONARY ARTERY; RADIONUCLIDE VENTRICULOGRAPHY; STROKE VOLUME; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, RIGHT;

EID: 79251486316     PISSN: 18975593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bauersachs J, Widder JD. Endothelial dysfunction in heart failure. Pharmacol Rep, 2008; 60: 119-126.
2. Anguita M, Ojeda S. Diagnóstico y tratamiento de la insuficiencia cardiaca diastólica. Rev Esp Cardiol, 2004; 57: 570-575.
3. Aurigemma G, Gaasch W. Diastolic heart failure. New Eng J Med, 2004; 351: 1097-1105.
4. Shapiro B, Nishimura R, McGoon M, Redfield M. Diagnostic dilemmas: diastolic heart failure causing pulmonary hypertension, pulmonary hypertension causing diastolic dysfunction. Adv Pulmon Hypertens, 2006; 5: 13-20.
5. Lam C, Roger V, Rodeheffer R, Borlaug B, Enders F, Redfield M. Pulmonary hypertension in heart failure with preserved ejection fraction. A community-based study. J Am Coll Cardiol, 2009; 53: 1119-1126.
6. Rector TS, Bank AJ, Mullen KA et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation, 1996; 93: 2135-2141.
7. Böger RH, Bode-Böger SM. The clinical pharmacology of L-arginine. Annu Rev Pharmacol Toxicol, 2001; 41: 79-99.
8. Hambrecht R, Hilbrich L, Erbs S et al. Correction of endothelial dysfunction in chronic heart failure: Additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol, 2000; 35: 706-713.
9. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev, 2006; 24: 275-290.
10. Kaye DM, Parnell MM, Ahlers BA. Reduced myocardial and systemic L-arginine uptake in heart failure. Circ Res, 2002; 91: 1198-1203.
11. Visek WJ. Arginine needs physiological state and usual diets: A reevaluation. J Nutr, 1986; 116: 36-46.
12. Zieve L. Conditional deficiencies of ornithine or arginine. J Am Coll Nutr, 1986; 5: 167-176.
13. Raij L, Cofee K, Guerra J, Holmes D. Glomerular thrombosis in pregnancy: Role of the L-arginine-nitric oxide pathway. Kidney Int, 1994; 45: 775-781.
14. Kashyap ML, Sivasamboo R, Sothy SP, Cheah JS, Gartside PS. Carbohydrate and lipid metabolism during human labor: Free fatty acids, glucose, insulin, and lactic acid metabolism during normal and oxytocin-induced labor for postmaturity. Metabolism, 1976; 25: 865-875.
15. Kerr GR. The free amino acids of serum during development of Macaca mulatta: II. During pregnancy and fetal life. Pediatr Res, 1968; 2: 493-500.
16. Ogburn PL Jr, Johnson SB, Williams PP, Holman RT. Levels of free fatty acids and arachidonic acid in pregnancy and labor. J Lab Clin Med, 1980; 95: 943-949.
17. Whaley WH, Zuspan FP, Nelson GH, Ahlquist RP. Alterations of plasma free fatty acids and glucose during labor. Am J Obstet Gynecol, 1967; 97: 875-880.
18. Milakofsky L, Harris N, Vogel WH. Effects of repeated stress on plasma arginine levels in young and old rats. Physiol Behav, 1993; 54: 725-728.
19. Arnold JM, Massie BM, Baker DWet al. HFSA 2006 Comprehensive HF Practice Guideline. J Card Fail, 2006; 12: e1-e122.
20. Voelkel NF, Quaife RA, Leinwand LA et al. Right ventricular function and failure. Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Circulation, 2006; 114: 1183-1891.
21. Setaro JF, Cleman MW, Remetz MS. The right ventricle in disorders causing pulmonary venous hypertension. Cardiol Clin, 1992; 10: 165-183.
22. Corbett JR, Akinboboye OO, Bacharach SL et al. Equilibrium radionuclide angiocardiography. J Nucl Card, 2006; 13: e56-e79.
23. Galie N, Hoeper MM, Humbert M et al. Guidelines for diagnosis and treatment of pulmonary hypertension. The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Resp J, 2009; 34: 1219-1263.
24. Galie N, Torbicki A, Barst R et al. Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology (ESC). Guidelines on diagnosis and treatment of pulmonary arterial hypertension. Eur Heart J, 2004; 25: 2243-2278.
25. Mehta S, Steart DJ, Langleben D, Levy RD. Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation, 1995; 92: 1539-1545.
26. Suradacki A, Zmudka K, Bieron K, Kostka-Trabka E, Dubiel JS, Gryglewski RJ. Lack of beneficial effects of L-arginine infusion in primary pulmonary hypertension. Wien Klin Wochenschr, 1994; 106: 521-526.
27. Vosatka RJ, Kashyap S, Trifiletti RR. Arginine deficiency accompanies persistent pulmonary hypertension of the newborn. Biol Neonate, 1994; 66: 65-70.
28. McCaffrey MJ, Bose CL, Reiter PD, Stiles AD. Effect of L-arginine infusion on infants with persistent pulmonary hypertension of the newborn. Biol Neonate, 1995; 67: 240-243.
29. Mitani Y, Maruyama K, Sakurai M. Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation, 1997; 96: 689-697.
30. Perticone F, Ceravolo R, Pujia A et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation, 2001; 104: 191-196.
31. Smith HA, Canter JA, Christian KG et al. Nitric oxide precursors and congenital heart surgery: A randomized controlled trial of oral citrulline. J Thorac Cardiovasc Surg, 2006; 132: 58-65.
32. Nagaya N, Uematsu M, Oya H et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med, 2001; 163: 887-891.
33. Koifman B, Topilski I, Megidish R et al. Endothelial cell function, and hemodynamic variables in patients with heart failure secondary to coronary heart disease. Am J Cardiol, 2006; 98: 172-177.
34. Lim DS, Mooradian SJ, Goldberg CS et al. Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients. Am J Cardiol, 2004; 94: 828-831.
35. Silva-Tinoco R, Castillo-Martínez L, Orea-Tejeda A et al. Effect of left ventricular dysfunction on right ventricle ejection fraction during exercise in heart failure patients: Implications in functional capacity and blood pressure response. Cardiol J, 2009; 16: 127-132.
36. Orea-Tejeda A, Sánchez-González R, Castillo-Martínez L et al. Troponin elevation and its association with renal dysfunction, clinical findings in heart failure patients. Cardiol J, 2010; 17: 42-48.